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3-Chloro-2,6-difluorobenzonitrile

3-Chloro-2,6-difluorobenzonitrile structure

CAS No.: 86225-73-2

Chemical Name:: 3-Chloro-2,6-difluorobenzonitrile

Synonyms: 3-Chloro-2,6-difluorobenzonitrile;Benzonitrile, 3-chloro-2,6-difluoro-

CBNumber:: CB0717863

Molecular Formula:: C7H2ClF2N

Molecular Weight:: 173.55

MDL Number:: MFCD06660172

MOL File:: 86225-73-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:48:28

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3-Chloro-2,6-difluorobenzonitrile Properties

refractive index	1.5125
storage temp.	Sealed in dry,Room Temperature
Appearance	Colorless to light yellow Liquid
Water Solubility	Not miscible or difficult to mix with water.
CAS DataBase Reference	86225-73-2

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H302-H311-H315-H319-H332

Precautionary statements

P280h-P305+P351+P338-P309-P310

HazardClass

6.1

HS Code

2926907090

NFPA 704

	1
3		0

3-Chloro-2,6-difluorobenzonitrile price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC302088	3-Chloro-2,6-difluorobenzonitrile 98%	86225-73-2	1g	$21	2026-06-04	Buy
Apolloscientific	PC302088	3-Chloro-2,6-difluorobenzonitrile 98%	86225-73-2	5g	$24	2026-06-04	Buy
Apolloscientific	PC302088	3-Chloro-2,6-difluorobenzonitrile 98%	86225-73-2	10g	$30	2026-06-04	Buy
Activate Scientific	AS140404	3-Chloro-2,6-difluorobenzonitrile 96%	86225-73-2	5g	$40	2026-06-04	Buy
Activate Scientific	AS140404	3-Chloro-2,6-difluorobenzonitrile 96%	86225-73-2	25g	$119	2026-06-04	Buy

Product number	Packaging	Price	Buy
PC302088	1g	$21	Buy
PC302088	5g	$24	Buy
PC302088	10g	$30	Buy
AS140404	5g	$40	Buy
AS140404	25g	$119	Buy

3-Chloro-2,6-difluorobenzonitrile Chemical Properties, Uses, Production

Uses

3-Chloro-2,6-difluorobenzonitrile is used as a pharmaceutical intermediate.

Synthesis

4681-11-2

86225-73-2

(2) Fluorination step: In 800 g of dimethyl sulfoxide (DMSO), 206.5 g of 2,3,6-trichlorobenzonitrile was dissolved, followed by the addition of 145.3 g of potassium fluoride (KF) to the solution. The reaction mixture was heated to 170 °C with continuous stirring and maintained for 1.5 hours. After completion of the reaction, the mixture was poured into water and extracted with dichloromethane (DCM). After removing the solvent by distillation, the reaction mixture was further distilled and the fraction with a boiling point of 95 °C/11 mmHg was collected to give 166.6 g of 3-chloro-2,6-difluorobenzonitrile in 96.0% yield.

References

[1] Patent: US4406841, 1983, A

3-Chloro-2,6-difluorobenzonitrile Preparation Products And Raw materials

Raw materials

Benzonitrile, 2,3,6-trichloro- Potassium Dimethyl sulfoxide

Preparation Products

3-Chloro-2,6-difluorobenzonitrile Suppliers

Global Suppliers ( 105)

Supplier	Tel	Email	Country	ProdList	Advantage
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan ariel chemical Co., LTD.	18986259541 18986259541	sales@3stc.com	China	3830	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Hangzhou J&H Chemical Co., Ltd.	0571-87396432	sales@jhechem.com	China	14905	59
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66028182 17714375163	yftan@aikonchem.com	China	16674	50
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58
Changzhou Anxuan Chemical, Co., Ltd.	13912302692	sales@anxuanchem.com	China	4824	58
Zhengzhou Alfachem Co., Ltd.	0371-53765687 18937137882	3969243885@qq.com	China	7734	55

Supplier	Advantage
Alfa Aesar	84
Ark Pharm, Inc.	56
Energy Chemical	61
Wuhan ariel chemical Co., LTD.	58
Bide Pharmatech Ltd.	60
Hangzhou J&H Chemical Co., Ltd.	59
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	50
Cool Pharm, Ltd	58
Changzhou Anxuan Chemical, Co., Ltd.	58
Zhengzhou Alfachem Co., Ltd.	55

View Latest Price from 3-Chloro-2,6-difluorobenzonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-24	3-CHLORO-2,6-DIFLUOROBENZONITRILE 86225-73-2		1KG	98%	20Tons	Shaanxi Dideu New Materials Co. Ltd
2026-03-20	3-CHLORO-2,6-DIFLUOROBENZONITRILE 86225-73-2		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2019-07-10	3-CHLORO-2,6-DIFLUOROBENZONITRILE 86225-73-2	$3.00	1KG	99%	100kg	Career Henan Chemical Co

3-CHLORO-2,6-DIFLUOROBENZONITRILE
86225-73-2
98%
Shaanxi Dideu New Materials Co. Ltd

3-CHLORO-2,6-DIFLUOROBENZONITRILE
86225-73-2
99%
Hebei Chuanghai Biotechnology Co., Ltd

3-CHLORO-2,6-DIFLUOROBENZONITRILE
86225-73-2
$3.00
99%
Career Henan Chemical Co

3-Chloro-2,6-difluorobenzonitrile Spectrum

3-CHLORO-2,6-DIFLUOROBENZONITRILE(86225-73-2)¹HNMR

86225-73-2 (3-Chloro-2,6-difluorobenzonitrile) Related Search:

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Benzonitrile, 3-chloro-2,6-difluoro- 3-Chloro-2,6-difluorobenzonitrile 86225-73-2