Ethyl 4-methyl-1,3-oxazole-5-carboxylate
- CAS No.
- 20485-39-6
- Chemical Name:
- Ethyl 4-methyl-1,3-oxazole-5-carboxylate
- Synonyms
- EINECS 243-848-9;4-methyl-1,3-oxazole-5-carboxylate;ethyl 4-methyloxazole-5-carboxylate;5-(Ethoxycarbonyl)-4-methyl-1,3-oxazole;ETHYL 4-METHYL-1,3-OXAZOLE-5-CARBOXYLATE;Ethyl 4-Methyloxazole-5-carboxylate, 97+%;4-METHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;5-Oxazolecarboxylic acid, 4-methyl-, ethyl ester
- CBNumber:
- CB0729936
- Molecular Formula:
- C7H9NO3
- Molecular Weight:
- 155.15
- MDL Number:
- MFCD00062573
- MOL File:
- 20485-39-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 38 °C |
|---|---|
| Boiling point | 62°C/1.5mmHg(lit.) |
| Density | 1.139±0.06 g/cm3(Predicted) |
| refractive index | 1.4680 to 1.4720 |
| storage temp. | 2-8°C |
| form | clear liquid |
| pka | -0.80±0.14(Predicted) |
| color | Colorless to Light orange to Yellow |
| CAS DataBase Reference | 20485-39-6 |
| FDA UNII | IKW37IL2S5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2934999090 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Ethyl 4-methyl-1,3-oxazole-5-carboxylate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1270 | Ethyl 4-Methyloxazole-5-carboxylate >96.0%(GC) | 20485-39-6 | 1g | $95 | 2026-04-30 | Buy |
| AstaTech | 50174 | ETHYL 4-METHYLOXAZOLE-5-CARBOXYLATE 97% | 20485-39-6 | 1G | $50 | 2026-04-30 | Buy |
| AstaTech | 50174 | ETHYL 4-METHYLOXAZOLE-5-CARBOXYLATE 97% | 20485-39-6 | 5G | $149 | 2026-04-30 | Buy |
| AstaTech | 50174 | ETHYL 4-METHYLOXAZOLE-5-CARBOXYLATE 97% | 20485-39-6 | 10G | $226 | 2026-04-30 | Buy |
| Apolloscientific | OR28307 | Ethyl 4-methyl-1,3-oxazole-5-carboxylate ≥95% | 20485-39-6 | 250mg | $21 | 2026-06-04 | Buy |
Ethyl 4-methyl-1,3-oxazole-5-carboxylate Chemical Properties,Uses,Production
Synthesis
584-08-7
609-15-4
20485-39-6
Example 1 Preparation of ethyl 4-methyl-5-oxazolecarboxylate: the compound was prepared according to the method described in French Patent No. 4,522,587. A mixture of 50.0 g (0.337 mol) of ethyl 2-chloroacetoacetate and 42.0 g (0.933 mol) of formamide was stirred and reacted at 120°C to 135°C for 18 hours. Upon completion of the reaction, the reaction mixture was cooled to 10°C using an ice bath. 300 mL of 1N potassium carbonate (K2CO3) solution was slowly added dropwise, taking care to control the rate of gas escape. After dropwise addition, the reaction mixture was mixed with 200 mL of benzene/ether (2:1, v/v), stirred and saturated with sodium chloride (NaCl). The insoluble material was removed by filtration, the organic layer (benzene/ether layer) was separated, washed with water, dried over anhydrous magnesium sulfate (MgSO4) and subsequently concentrated under reduced pressure. The resulting brown residue was distilled through a Kugelrohr distillation apparatus to give 14.8 g of white solid product with a melting point of 31 °C to 33 °C. The yield was 31%; nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3) data were as follows: δ 8.0 (single peak, 1H, C2H), 4.4 (quartet, J = 7 Hz, 2H, CH2), 2.5 (single peak, 3H, CH3), 1.4 (triple peak, 3H, CH3).
References
[1] Patent: US4303439, 1981, A
Ethyl 4-methyl-1,3-oxazole-5-carboxylate Preparation Products And Raw materials
Ethyl 4-methyl-1,3-oxazole-5-carboxylate Suppliers
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