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Trityl candesartan

Trityl candesartan structure

CAS No.: 139481-72-4

Chemical Name:: Trityl candesartan

Synonyms: Triphenyl Candesartan;TRITYL CANDESARTAN;N-tityl candesartan;Trityl Candesaratan;N-Trityl Candesartan;N-trimethylcandesartan;Trityl Candesartan (C9);Tricycliccandesartan(C9);Candesartan Impurity 8;CANDESARTAN INTERMEDIATE A

CBNumber:: CB0763835

Molecular Formula:: C43H34N6O3

Molecular Weight:: 682.77

MDL Number:: MFCD08436154

MOL File:: 139481-72-4.mol

MSDS File:: SDS

Last updated:2026-07-16 07:06:08

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Trityl candesartan Properties

Melting point	163-165°C
Boiling point	908.6±75.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	2.06±0.10(Predicted)
color	White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302-H410
Precautionary statements	P264-P270-P301+P312-P330-P501-P273-P391-P501
REACH Registrations	Active

Trityl candesartan price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	022551	N-Trityl Candesartan	139481-72-4	10mg	$453	2026-06-03	Buy
Biosynth	FT28595	N-Trityl candesartan	139481-72-4	5g	$354	2026-06-04	Buy
Biosynth	FT28595	N-Trityl candesartan	139481-72-4	10g	$531	2026-06-04	Buy
Biosynth	FT28595	N-Trityl candesartan	139481-72-4	25g	$885	2026-06-04	Buy
ChemScene	CS-W006659	Trityl candesartan ≥98%	139481-72-4	5g	$240	2026-06-04	Buy

Product number	Packaging	Price	Buy
022551	10mg	$453	Buy
FT28595	5g	$354	Buy
FT28595	10g	$531	Buy
FT28595	25g	$885	Buy
CS-W006659	5g	$240	Buy

Trityl candesartan Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

2-Ethoxy-1-((2''-(1-trityl-1H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic Acid can be used as reagent/reactant in preparation of the anti-hypertensive drug candesartan cilexetil.

Uses

Candesartan analog as angiotensin II antagonist.

Synthesis

76-83-5

139481-59-7

139481-72-4

I. 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid (10 kg) was added to the reaction kettle along with dichloromethane (100 kg), and cooled down to 15°C. The temperature of the reaction system was increased to 15°C by adding triethylamine (4.5 kg). Triethylamine (4.5 kg) was slowly added dropwise, and after the dropwise addition was completed, the temperature of the reaction system was raised to 23 °C. Triphenylchloromethane (7kg) was added in batches and after completion of addition, the reaction was maintained at 23°C for 3.5 hours. The reaction progress was monitored by TLC (unfolding agent: dichloromethane/methanol=10:1, v/v, Rf=0.78). After completion of the reaction, the pH of the system was adjusted to 5.4 by adding 0.1 mol/L HCl (30 L), then 5 L of 9 mol/L HCl was added slowly to pH=2.2, and the reaction was allowed to stand for stratification to separate the aqueous and organic layers. The organic layer (about 60 L) was washed with saturated saline, transferred to a reduced pressure distillation unit, and dichloromethane was recovered under reduced pressure. Ethanol (65L) was added to the residue, warmed to 45°C and stirred for 3 hours until a large amount of white solid precipitated. The heating was stopped, cooled to room temperature, filtered, the filter cake was washed with a small amount of ethanol, and dried at 50°C under normal pressure for 12 hours to obtain 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid (white crystalline powder, 14.5 kg, yield 94.0%).

References

[1] Patent: CN105153124, 2018, B. Location in patent: Paragraph 0005; 0054; 0055; 0076; 0090
[2] Patent: WO2009/7986, 2009, A1. Location in patent: Page/Page column 13
[3] Patent: US2010/210852, 2010, A1. Location in patent: Page/Page column 5
[4] Patent: WO2009/7986, 2009, A1. Location in patent: Page/Page column 14

Trityl candesartan Preparation Products And Raw materials

Raw materials

Triphenylmethyl Chloride Candesartan Dichloromethane Triethylamine

Preparation Products

Trityl candesartan Suppliers

Global( 242)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-83725681-603		China	4484	50
Moltt Biocem Co., Ltd.	+86-21-38682181 15900741819		China	281	55
Shanghai Huikai Chemical Technology Co., Ltd.	021-61995394 18916691159	chemicalsea@163.com	China	1970	58
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Quality Control Solutions Ltd.	0755-66853366 13670046396	orders@qcsrm.com	China	18188	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58

Supplier	Advantage
Adamas Reagent, Ltd.	59
Chemsky (shanghai) International Co.,Ltd	60
XiaoGan ShenYuan ChemPharm co,ltd	52
BioBioPha Co., Ltd.	65
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
Moltt Biocem Co., Ltd.	55
Shanghai Huikai Chemical Technology Co., Ltd.	58
HBCChem, Inc.	60
Quality Control Solutions Ltd.	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58

View Lastest Price from Trityl candesartan manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-16	Trityl candesartan 139481-72-4		1kg	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
2025-04-15	Trityl Candesartan 139481-72-4	$120.00	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd
2022-09-29	Trityl candesartan 139481-72-4	$28.00-30.00	1Kg	99.0% up	50 tons per month	Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Trityl candesartan
139481-72-4
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Trityl Candesartan
139481-72-4
$120.00
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Trityl candesartan
139481-72-4
$28.00-30.00
99.0% up
Xinxiang Hongqi District Houyuan Trading Co.,Ltd

139481-72-4(Trityl candesartan)Related Search:

Kresoxim-methyl Trityl Irbesartan TRITYL CANDESARTAN CILETEXITIL,TRITYL CANDESARTAN CILEXETIL,Trityl candesartan Methyl ester Methyl salicylate Candesartan cilexetil

Benzimidazole Candesartan 5-Methyl-1H-benzotriazole Ethoxyquin Tribenuron methyl

Triphenylmethyl Chloride 4-Ethoxyphenol Biphenyl Thiophanate-methyl Benzotrifluoride

Diethoxymethane Methyl O-Desethyl Candesartan N1-Cilexetil Ethyl Ester

1of4

Candesartan N1-Trityl IMpurity 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-c 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole- 2-ethoxy-1-[[(2'-(1-triphenylmethyl-1h-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-carboxylic acid TRITYL CANDESARTAN (Trityl candesartan)2-Ethoxy-1-[[2-(2-Triphenyl Methyl)-2H-Tetrazole-5-YL](1,1-Biphenyl)-4-YL]Methyl]Benzimidazole-2-Carboxylic Acid 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]- 2-Ethoxy-1-[[(2’-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl-)methyl]benzimidazole-7-carboxylicacid Triphenyl Candesartan TRITYL CANDESARTAN ( FOR CANDESARTAN CILEXETIL ) TritylCandesartan[CandesartabCilexetilIntermediates] TritylCandesartan,CandesartanCilexetil (1H)-Benzimidazole-7-carboxylicacid CANDESARTAN INTERMEDIATE A 2-ethoxy-3-[[4-[2-[1-(triphenylmethyl)-5-tetrazolyl]phenyl]phenyl]methyl]-4-benzimidazolecarboxylic acid Candesartan Cilexetil Impurity 9 2-Ethoxy-1-[[2-(2-Triphenylmethyl)-2H-Tetrazole-5-Yl](1,1-Biphenyl)-4-Yl]-Methyl]Benzimidazole-7-Carboylicacid 2-ethoxy-1-[[(2-(1-triphenylmethyl-1Htetrazol-5-yl)biphenyl-4-yl-) N-Trityl Candesartan Trityl candesartan/2-Ethoxy-1-[[(2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole-7-carboxylic acid 2-ETHOXY-1-[[(2-(1-TRIPHENYLMETHYL-1H-TETRAZOL-5-YL)BIPHENYL)METHYL] BENZIMIDAZOLE-7-CARBOXYLIC ACID Candesartan Impurity 8 1H-benzimidazole-7-carboxylic acid, 1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-2-ethoxy Candesartan Cilexetil Impurity 14 Trityl Candesartan (C9) N-trimethylcandesartan Trityl candesartan USP/EP/BP 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic Acid DISCONTINUED 2-Ethoxy-1-[[2?-[2-(Triphenylmethyl)-2H-Tetrazol-5- Yl][1,1?-Biphenyl]-4-Yl]Methyl]-1H-Benzimidazole-7- Carboxylic Acid [N-Trityl Candesartan] Candesartan Cilexetil Intermediate 5 N-tityl candesartan 2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid Trityl Candesaratan 2-Ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid Triphenyl candesartan ester Trityl candesartan (Candesartan Cilexetil Impurity) Tricycliccandesartan(C9) 139481-72-4 C43H34N6O3 Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Intermediates of Candesartan Candesartan Cilexetil API intermediates INTERMEDIATESOF Intermediates