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NIKKOMYCIN Z

NIKKOMYCIN Z structure

CAS No.: 59456-70-1

Chemical Name:: NIKKOMYCIN Z

Synonyms: NIKKOMYCIN;huaguamycin;neopolyoxinc;NIKKOMYCIN Z;(2s-(2r*,3r*,4r*))-l);NIKKOMYCIN Z, STREPTOMYCES TENDAE;Nikkomycin Z, Sterptomyces tendae;nikkomycin Z from streptomyces tendae;5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci;5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid

CBNumber:: CB0767000

Molecular Formula:: C20H25N5O10

Molecular Weight:: 495.44

MDL Number:: MFCD00869648

MOL File:: 59456-70-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-30 17:22:44

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NIKKOMYCIN Z Properties

Density	1.646±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: soluble5mg/mL
pka	2.70±0.10(Predicted)
form	Solid
color	White to off-white
Water Solubility	Water : ≥ 100 mg/mL (201.84 mM)
InChIKey	WWJFFVUVFNBJTN-JKEIIPFCSA-N
SMILES	C[C@@H]([C@H](N)C(=O)N[C@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O)C(O)=O)[C@H](O)c3ccc(O)cn3
FDA UNII	9Z22C3QQCJ
UNSPSC Code	51102829
NACRES	NA.85

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H315-H319
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	BA2928200
F	10
Storage Class	11 - Combustible Solids

NIKKOMYCIN Z price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N8028	Nikkomycin Z from Streptomyces tendae ≥90% (HPLC)	59456-70-1	5mg	$582	2026-04-30	Buy
Biosynth	JCA45670	Nikkomycin Z from streptomyces tendae	59456-70-1	1mg	$1031.25	2026-06-04	Buy
Biosynth	JCA45670	Nikkomycin Z from streptomyces tendae	59456-70-1	2mg	$1375	2026-06-04	Buy
Biosynth	JCA45670	Nikkomycin Z from streptomyces tendae	59456-70-1	5mg	$2062.5	2026-06-04	Buy
ChemScene	CS-0015875	Nikkomycin Z 98.62%	59456-70-1	1mg	$504	2026-06-04	Buy

Product number	Packaging	Price	Buy
N8028	5mg	$582	Buy
JCA45670	1mg	$1031.25	Buy
JCA45670	2mg	$1375	Buy
JCA45670	5mg	$2062.5	Buy
CS-0015875	1mg	$504	Buy

NIKKOMYCIN Z Chemical Properties,Uses,Production

Description

Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.

Uses

Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.

Definition

ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.

Pharmacology

By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.

Metabolism

There are no detailed reports on metabolism/transformation of nikkomycins in the environment.

NIKKOMYCIN Z Preparation Products And Raw materials

Raw materials

Preparation Products

NIKKOMYCIN Z Suppliers

Global( 50)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9331	58
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15775	55
Shanghai Synchem Pharma Co., ltd	21-619849051-1 18521059765	synchempharma@aliyun.com	China	4988	55
Shanghai Haozhixiang Biotechnology Co., Ltd	526763801 13301653310	526763801@qq.com	China	7580	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Linka Biotechnology Co., Ltd.	18301977208	2126935757@qq.com	China	209	55
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9533	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15030	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58

Supplier	Advantage
Guangzhou Isun Pharmaceutical Co., Ltd	55
Finetech Industry Limited	58
Shanghai Macklin Biochemical Co.,Ltd.	55
Shanghai Synchem Pharma Co., ltd	55
Shanghai Haozhixiang Biotechnology Co., Ltd	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Linka Biotechnology Co., Ltd.	55
Finetech Industry Limited	58
AFINE CHEMICALS LIMITED	58
BOC Sciences	58

Mechanism of action of Nikkomycin Z
Nikkomycin Z is an experimental compound with antifungal properties. Like all nikkomycins, it consists of a pyrimidine nucleos....
Mar 31,2022

View Lastest Price from NIKKOMYCIN Z manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-06-30	Nikkomycin Z 59456-70-1		1kg	98	1000kgs	Shaanxi Dideu New Materials Co. Ltd

Nikkomycin Z
59456-70-1
$0.00
98
Shaanxi Dideu New Materials Co. Ltd

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NIKKOMYCIN Z NIKKOMYCIN Z, STREPTOMYCES TENDAE (2s-(2r*,3r*,4r*))-l) 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny neopolyoxinc nikkomycin Z from streptomyces tendae Nikkomycin Z, Sterptomyces tendae 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid 5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid β-D-Allofuranuronic acid, 5-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)- huaguamycin NIKKOMYCIN 59456-70-1 C20H25N5O10 BioChemical Antibiotics Antibiotics A to Z Antibiotics N-S AntifungalGlycobiology InhibitorsAntibiotics Peptidyl NucleosidesMore...Close... Inhibitors and Substrates Peptidyl Nucleosides Antibiotics Antibiotics A to Antibiotics N-SAntibiotics AntifungalAntibiotics Chemical Structure Class Inhibits an EnzymeAntibiotics Interferes with Cell Wall SynthesisAntibiotics Mechanism of Action Spectrum of Activity