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NIKKOMYCIN Z

NIKKOMYCIN Z structure

CAS No.: 59456-70-1

Chemical Name:: NIKKOMYCIN Z

Synonyms: NIKKOMYCIN;huaguamycin;neopolyoxinc;NIKKOMYCIN Z;(2s-(2r*,3r*,4r*))-l);NIKKOMYCIN Z, STREPTOMYCES TENDAE;Nikkomycin Z, Sterptomyces tendae;nikkomycin Z from streptomyces tendae;5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci;5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid

CBNumber:: CB0767000

Molecular Formula:: C20H25N5O10

Molecular Weight:: 495.44

MDL Number:: MFCD00869648

MOL File:: 59456-70-1.mol

Last updated:2024-07-02 08:54:58

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NIKKOMYCIN Z Properties

Density	1.646±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H2O: soluble5mg/mL
form	Solid
pka	2.70±0.10(Predicted)
color	White to off-white
Water Solubility	Water : ≥ 100 mg/mL (201.84 mM)
FDA UNII	9Z22C3QQCJ

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H315-H319
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	BA2928200
F	10

NIKKOMYCIN Z price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N8028	Nikkomycin Z from Streptomyces tendae ≥90% (HPLC)	59456-70-1	5mg	$437	2024-03-01	Buy
AK Scientific	X6882	Nikkomycin Z from Streptomyces tendae	59456-70-1	5mg	$460	2021-12-16	Buy
American Custom Chemicals Corporation	API0012075	NIKKOMYCIN 95.00%	59456-70-1	5MG	$502.55	2021-12-16	Buy
AHH	MT-56998	NikkomycinZ 98%	59456-70-1	0.005g	$330	2021-12-16	Buy

Product number	Packaging	Price	Buy
N8028	5mg	$437	Buy
X6882	5mg	$460	Buy
API0012075	5MG	$502.55	Buy
MT-56998	0.005g	$330	Buy

NIKKOMYCIN Z Chemical Properties,Uses,Production

Description

Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.

Uses

Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.

Definition

ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.

Pharmacology

By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.

Metabolism

There are no detailed reports on metabolism/transformation of nikkomycins in the environment.

NIKKOMYCIN Z Preparation Products And Raw materials

Raw materials

Preparation Products

NIKKOMYCIN Z Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15417	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9642	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38663	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618501500038	3899766280@qq.com	China	26362	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618791163155	18791163155@163.com	China	3558	58
Aladdin Scientific		tp@aladdinsci.com	United States	52924	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	12952	65
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4720	55
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9650	58

Supplier	Advantage
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58
BOC Sciences	65
Guangzhou Isun Pharmaceutical Co., Ltd	55
Finetech Industry Limited	58

Mechanism of action of Nikkomycin Z
Nikkomycin Z is an experimental compound with antifungal properties. Like all nikkomycins, it consists of a pyrimidine nucleos....
Mar 31，2022

59456-70-1(NIKKOMYCIN Z)Related Search:

NIKKOMYCIN Z PROPYL-(TETRAHYDRO-FURAN-2-YLMETHYL)-AMINE D-HOMOCITRULLINE (S)-(+)-Tetrahydrofurfurylamine GLYCYL-D-THREONINE DIHYDRATE

AC-D-NLE-OH GLYCYL-D-SERINE (2R,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID 4-PYRIDIN-2-YL-BUTYLAMINE Nikkomycin M

dl-3-hydroxynorvaline AC-D-LYS-OH GLYCYL-D-THREONINE Nikkomycin N Nikkomycin J

Nikkomycin pseudo-J nikkomycin L(z) nikkomycin L(x)

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NIKKOMYCIN NIKKOMYCIN Z NIKKOMYCIN Z, STREPTOMYCES TENDAE (2s-(2r*,3r*,4r*))-l) 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny neopolyoxinc nikkomycin Z from streptomyces tendae Nikkomycin Z, Sterptomyces tendae 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid 5-[[(2S,3S,4S)-2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid 5-((2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicacid β-D-Allofuranuronic acid, 5-[[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)- huaguamycin 59456-70-1 C20H25N5O10 BioChemical Antibiotics Antibiotics A to Z Antibiotics N-S AntifungalGlycobiology InhibitorsAntibiotics Peptidyl NucleosidesMore...Close... Inhibitors and Substrates Peptidyl Nucleosides Antibiotics Antibiotics A to Antibiotics N-SAntibiotics AntifungalAntibiotics Chemical Structure Class Inhibits an EnzymeAntibiotics Interferes with Cell Wall SynthesisAntibiotics Mechanism of Action Spectrum of Activity