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4-Chloro-3-nitrobenzenesulfonyl chloride

4-Chloro-3-nitrobenzenesulfonyl chloride structure

CAS No.: 97-08-5

Chemical Name:: 4-Chloro-3-nitrobenzenesulfonyl chloride

Synonyms: Yel;4-CHLORO-3-NITROBENZENESULPHONYL CHLORIDE;4-CHLORO-3-NITROBENZENE-1-SULFONYL CHLORIDE;4-Chloro-3-nitrobenz;YELLOW SULFON CHLORIDE;3-Nitro-4-chlorobenzensulfonyl;4-Chloro-3-nitrobenzenesulfonyl;3-nitro-4-chlorosulfonyl chloride;3-NITRO-4-CHLOROBENZENSULFONYL CHLORIDE;4-chloro-3-nitro-benzenesulfonylchlorid

CBNumber:: CB0776970

Molecular Formula:: C6H3Cl2NO4S

Molecular Weight:: 256.06

MDL Number:: MFCD00007440

MOL File:: 97-08-5.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:26

Product description	Number	Pack Size	Price
4-Chloro-3-nitrobenzenesulfonyl chloride 96%	C59408	25g	$37.6
4-Chloro-3-nitrobenzenesulfonyl Chloride >96.0%(GC)(T)	C1887	5g	$93
4-Chloro-3-nitrobenzenesulfonyl Chloride >96.0%(GC)(T)	C1887	25g	$299
4-Chloro-3-nitrobenzenesulfonyl chloride	C350280	1g	$55
4-Chloro-3-nitrobenzenesulfonyl chloride	C350280	5g	$65
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4-Chloro-3-nitrobenzenesulfonyl chloride Properties

Melting point	59-60 °C (lit.)
Boiling point	356°C (rough estimate)
Density	1.696 (estimate)
refractive index	1.6000 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Toluene
form	Crystalline Powder
color	Light brown
Sensitive	Moisture Sensitive
BRN	1978600
InChI	1S/C6H3Cl2NO4S/c7-5-2-1-4(14(8,12)13)3-6(5)9(10)11/h1-3H
InChIKey	SEWNAJIUKSTYOP-UHFFFAOYSA-N
SMILES	[O-][N+](=O)c1cc(ccc1Cl)S(Cl)(=O)=O
CAS DataBase Reference	97-08-5(CAS DataBase Reference)
FDA UNII	9H74VBH6E8
NIST Chemistry Reference	Benzenesulfonyl chloride, 4-chloro-3-nitro-(97-08-5)
EPA Substance Registry System	Benzenesulfonyl chloride, 4-chloro-3-nitro- (97-08-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H290-H318-H314

Precautionary statements

P280-P305+P351+P338-P310-P234-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501-P260h-P301+P330+P331-P303+P361+P353-P501a

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

34-29-14

Safety Statements

26-27-28-36/37/39-45-8-30-22

RIDADR

UN 3261 8/PG 2

WGK Germany

Hazard Note

Corrosive

TSCA

TSCA listed

HazardClass

PackingGroup

HS Code

29049090

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Eye Dam. 1
Skin Corr. 1B

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		2
	W

4-Chloro-3-nitrobenzenesulfonyl chloride price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C59408	4-Chloro-3-nitrobenzenesulfonyl chloride 96%	97-08-5	25g	$37.6	2023-06-20	Buy
TCI Chemical	C1887	4-Chloro-3-nitrobenzenesulfonyl Chloride >96.0%(GC)(T)	97-08-5	5g	$93	2025-07-31	Buy
TCI Chemical	C1887	4-Chloro-3-nitrobenzenesulfonyl Chloride >96.0%(GC)(T)	97-08-5	25g	$299	2025-07-31	Buy
TRC	C350280	4-Chloro-3-nitrobenzenesulfonyl chloride	97-08-5	1g	$55	2021-12-16	Buy
TRC	C350280	4-Chloro-3-nitrobenzenesulfonyl chloride	97-08-5	5g	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
C59408	25g	$37.6	Buy
C1887	5g	$93	Buy
C1887	25g	$299	Buy
C350280	1g	$55	Buy
C350280	5g	$65	Buy

4-Chloro-3-nitrobenzenesulfonyl chloride Chemical Properties,Uses,Production

Chemical Properties

LIGHT BROWN CRYSTALLINE POWDER

Uses

4-Chloro-3-nitrobenzenesulfonyl Chloride is used in the synthesis of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones which increases melanin synthesis in murine B16 cells.

Uses

4-Chloro-3-nitrobenzenesulfonyl chloride can be used:

In the preparation of functionalized 1H-indenes via copper-catalyzed arylative cyclization.
As a precursor in the synthesis of N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives that show potential nematicidal activity.
As a key starting material in the synthesis of sulfonamide analogs of ferrostatin-1 (fer-1), which possess good ferroptosis inhibition property.
In the synthesis of 4-chloro-3-nitrobenzene thiol.

Synthesis

potassium 4-chloro-3-nitrobenzenesulphonate

6671-49-4

97-08-5

Synthesis Example 2-2 Synthesis of 4-chloro-3-nitrobenzenesulfonyl chloride: to a reaction vial containing a mixture of 1280 g of potassium 4-chloro-3-nitrobenzenesulfonate, 1150 mL of acetonitrile, 250 mL of sulfoxide, and 30 mL of dimethylacetamide, 1240 mL of phosphinic acid chloride was added dropwise at a slow rate, while controlling the temperature within the reaction system to maintain a temperature of 60°C to 70°C. After the dropwise addition was completed, the reaction mixture was stirred at 73°C for 3 hours. Upon completion of the reaction, the reaction mixture was cooled with water, followed by the slow addition of 400 mL of water. The reaction mixture was poured into 5 L of ice water and the precipitated crystals were separated by filtration, washed with water and dried to give 1060 g of the target product 4-chloro-3-nitrobenzenesulfonyl chloride in 84% yield. The melting point of the product was 55 °C to 56 °C.

References

[1] Patent: US5221750, 1993, A
[2] Patent: US5071994, 1991, A

4-Chloro-3-nitrobenzenesulfonyl chloride synthesis

Synthesis of 4-Chloro-3-nitrobenzenesulfonyl chloride from 4-Chlorobenzenesulfonyl chloride

4-Chloro-3-nitrobenzenesulfonyl chloride Preparation Products And Raw materials

Raw materials

2-Nitrochlorobenzene Sulfuryl chloride 1,4-Benzenedisulfonic acid, 2-nitro- potassium 4-chloro-3-nitrobenzenesulphonate 4-Chloro-3-nitroaniline

4-CHLORO-3-NITROBENZENESULFONIC ACID, SODIUM SALT trichlorophosphate Chlorosulfonic acid 4-Chlorobenzenesulfonic acid 4-Chlorobenzenesulfonyl chloride

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Preparation Products

5-[[4-(aminosulphonyl)-2-nitrophenyl]amino]-2-[[4-[[4-(aminosulphonyl)-2-nitrophenyl]amino]phenyl]amino]benzenesulphonic acid 4-Chloro-3-nitrobenzenesulfonic acid Disperse Yellow Se-Fl 4-chloro-N-methyl-3-nitro-N-phenylbenzenesulphonamide 4-chloro-N-isopropyl-3-nitrobenzenesulphonamide

4-(4-CHLORO-3-NITRO-BENZENESULFONYL)-MORPHOLINE

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4-Chloro-3-nitrobenzenesulfonyl chloride Suppliers

Global( 256)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3995	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29832	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	9983	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 4-Chloro-3-nitrobenzenesulfonyl chloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	4-Chloro-3-nitrobenzenesulfonyl chloride 97-08-5	US $0.00-0.00 / KG	1KG	99.0%	1000KG	Shaanxi Dideu Medichem Co. Ltd
2021-10-21	4-Chloro-3-nitrobenzenesulfonyl chloride 97-08-5	US $10.00 / KG	1KG	99%	20 tons	Hebei Zhanyao Biotechnology Co. Ltd
2021-08-12	4-Chloro-3-nitrobenzenesulfonyl chloride 97-08-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

4-Chloro-3-nitrobenzenesulfonyl chloride
97-08-5
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

4-Chloro-3-nitrobenzenesulfonyl chloride
97-08-5
US $10.00 / KG
99%
Hebei Zhanyao Biotechnology Co. Ltd

4-Chloro-3-nitrobenzenesulfonyl chloride
97-08-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-Chloro-3-nitrobenzenesulfonyl chloride Spectrum

4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)MS 4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)¹HNMR 4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)¹³CNMR 4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)IR1 4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)IR2 4-Chloro-3-nitrobenzenesulfonyl chloride(97-08-5)Raman

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3-NITRO-4-CHLOROBENZENESULFONYL CHLORIDE 3-NITRO-4-CHLOROBENZENSULFONYL CHLORIDE 2-CHLORO-1-NITROBENZENE-5-SULFONYL CHLORIDE 4-CHLORO-3-NITROBENZENE-1-SULFONYL CHLORIDE 4-CHLORO-3-NITROBENZENESULFONYL CHLORIDE 4-CHLORO-3-NITROBENZENESULPHONYL CHLORIDE YELLOW SULFON CHLORIDE 4-chloro-3-nitro-benzenesulfonylchlorid 3-Nitro-4-chlorobenzensulfonyl 4-Chloro-3-nitrobenzenesulphonyl chloride 98% 3-NITRO-4-CHLOROBENZENESULFONYL CHLORIDE,98%+ 3-Nitro-4-chlorobenzenesulfonic acid chloride 4-Chloro-3-nitrobenzenesulfonyl chloride,99% Yel 4-Chloro-3-nitrobenzenesulfonyl chloride, 99% 25GR 4-Chloro-3-nitrobenz 2-Chloro-5-(chlorosulphonyl)nitrobenzene 4-Chloro-3-nitrobenzenesulfonyl 3-nitro-4-chlorosulfonyl chloride 4-Chloro-3-Nitrobenzenesulfonyl Chloride,≥95% Benzenesulfonyl chloride, 4-chloro-3-nitro- 4-Chloro-3-nitrobenzenesulfonyl chloride ISO 9001：2015 REACH -Chloro-3-nitrobenzenesulfonyl Chloride 97-08-5 1997-08-05 1997-8-5 35-64-7 1997-08-5 1997-08-5 C6H3NO4SCl2 ClC6H3NO2SO2Cl SULFONYL CHLORIDE Organic Building Blocks Sulfonyl Halides Sulfur Compounds Building Blocks Building Blocks Chemical Synthesis Organic Building Blocks Sulfonyl Halides Sulfur Compounds Benzene derivates Organic Building Blocks Sulfonyl Halides Sulfur Compounds Intermediates of Dyes and Pigments