4-Chloro-3-nitroaniline
- CAS No.
- 635-22-3
- Chemical Name:
- 4-Chloro-3-nitroaniline
- Synonyms
- 4-Chlor-3-nitroanilin;4-chloro-3-nitro-anilin;3-NITRO-4-CHLOROANILINE;4-CHLORO-3-NITROANILINE;Aniline, 4-chloro-3-nitro-;4-Chloro-3-nitrobenzenamine;4-chloro-3-nitro-benzenamin;4-Chloro-3-nitroaniline,97%;4-Chloro-3-nitroaniline >5-Amino-2-chloronitrobenzene
- CBNumber:
- CB8264060
- Molecular Formula:
- C6H5ClN2O2
- Molecular Weight:
- 172.57
- MDL Number:
- MFCD00007844
- MOL File:
- 635-22-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 99-101 °C (lit.) |
|---|---|
| Boiling point | 200°C (rough estimate) |
| Density | 1.5610 (rough estimate) |
| refractive index | 1.5870 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 1.87±0.10(Predicted) |
| form | powder to crystal |
| color | White to Yellow to Orange |
| BRN | 1309394 |
| Henry's Law Constant | 1.8×103 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | InChI=1S/C6H5ClN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2 |
| InChIKey | FOHHWGVAOVDVLP-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(Cl)C([N+]([O-])=O)=C1 |
| CAS DataBase Reference | 635-22-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | B13U77ZL3A |
| NIST Chemistry Reference | Benzenamine, 4-chloro-3-nitro-(635-22-3) |
| EPA Substance Registry System | 4-Chloro-3-nitroaniline (635-22-3) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS06,GHS08,GHS09,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H315-H319-H300-H310-H330-H373-H411 | |||||||||
| Precautionary statements | P301+P310a-P304+P340-P320-P330-P501a-P260-P264-P273-P280-P284-P302+P350-P262-P270-P271-P301+P310+P330-P302+P352+P310+P361+P364-P304+P340+P310-P305+P351+P338+P337+P313-P314-P391-P403+P233-P405-P501 | |||||||||
| Hazard Codes | T+,N,T | |||||||||
| Risk Statements | 26/27/28-33-51/53 | |||||||||
| Safety Statements | 28-36/37-45-61-28A | |||||||||
| RIDADR | UN 2237 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BX1750000 | |||||||||
| Hazard Note | Very Toxic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214210 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Dermal Acute Tox. 2 Inhalation Acute Tox. 4 Oral Aquatic Chronic 2 STOT RE 2 |
|||||||||
| Hazardous Substances Data | 635-22-3(Hazardous Substances Data) | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Chloro-3-nitroaniline price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1138 | 4-Chloro-3-nitroaniline >99.0%(GC)(T) | 635-22-3 | 25g | $18 | 2026-04-30 | Buy |
| TCI Chemical | C1138 | 4-Chloro-3-nitroaniline >99.0%(GC)(T) | 635-22-3 | 500g | $116 | 2021-12-16 | Buy |
| Biosynth | FC170383 | 4-Chloro-3-nitroaniline | 635-22-3 | 1kg | $1375 | 2026-06-04 | Buy |
| Biosynth | FC170383 | 4-Chloro-3-nitroaniline | 635-22-3 | 2kg | $2337.5 | 2026-06-04 | Buy |
| Biosynth | FC170383 | 4-Chloro-3-nitroaniline | 635-22-3 | 5kg | $4812.5 | 2026-06-04 | Buy |
4-Chloro-3-nitroaniline Chemical Properties, Uses, Production
Chemical Properties
ochre powder
Uses
Intermediate in the manufacture of azo dyes, pharmaceuticals, and other organic compounds.
Application
Commercial 4-chloro-3-nitroaniline could be used as a starting material for 3-azido-4-chlorophenylisothiocyanate through a 5-step synthesis. In order to research the impact of the strain on the metabolite profile of plasma samples in rats, 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) was evaluated for 4 weeks. 4C3N administration led to extravascular hemolytic anemia with a few metabolome changes, which were strain-dependent [1-2].
Hazard
Toxic by ingestion and inhalation.
Safety Profile
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx and Cl-.
References
[1] H. Lamotte. “Synthesis of N‐(3‐azido‐4‐chlorophenyl)‐N′‐[3H‐methyl] thiourea, an efficient photoaffinity probe for the urea carrier.” Journal of Labelled Compounds and Radiopharmaceuticals 42 1 (1994): 289–295.
[2] O’Donoghue, John L. “Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.” Fundamental and Applied Toxicology 6 3 (1986): Pages 551-558.
4-Chloro-3-nitroaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 |
Related articles
- Research on the toxicity of 4-chloro-3-nitroaniline
- The toxicity of 4-chloro-3-nitroaniline is similar to that of other aromatic nitro and amino chemicals.
- Jan 12,2024
View Latest Price from 4-Chloro-3-nitroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 4-Chloro-3-nitroaniline
635-22-3
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- 4-Chloro-3-nitroaniline
635-22-3
- $1.00
- 99.0%
- Career Henan Chemical Co
