(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
- CAS No.
- 354811-10-2
- Chemical Name:
- (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE
- Synonyms
- IKK2-IN-4;IKK-2 INHIBITOR VI;IKK2 Inhibitor VI,IKK-2 Inhibitor VI;(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide;2-(carbamoylamino)-5-phenylthiophene-3-carboxamide;2-[(AMinocarbonyl)aMino]-5-phenyl-3-thiophenecarboxaMide;3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-phenyl-;5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide|||IKK2 Inhibitor IV
- CBNumber:
- CB0789277
- Molecular Formula:
- C12H11N3O2S
- Molecular Weight:
- 261.3
- MDL Number:
- MFCD09037542
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| IKK2 Inhibitor VI ≥95% | 17276 | 500μg | $63 |
| IKK2 Inhibitor VI ≥95% | 17276 | 1mg | $111 |
| IKK2 Inhibitor VI ≥95% | 17276 | 5mg | $480 |
| (5-Phenyl-2-ureido)thiophene-3-carboxamide | P338250 | 2.5mg | $145 |
| 5-Phenyl-2-Ureidothiophene-3-Carboxamide | 8102CP | 5mg | $633 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17276 | IKK2 Inhibitor VI ≥95% | 354811-10-2 | 500μg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 17276 | IKK2 Inhibitor VI ≥95% | 354811-10-2 | 1mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 17276 | IKK2 Inhibitor VI ≥95% | 354811-10-2 | 5mg | $480 | 2024-03-01 | Buy |
| TRC | P338250 | (5-Phenyl-2-ureido)thiophene-3-carboxamide | 354811-10-2 | 2.5mg | $145 | 2021-12-16 | Buy |
| AK Scientific | 8102CP | 5-Phenyl-2-Ureidothiophene-3-Carboxamide | 354811-10-2 | 5mg | $633 | 2021-12-16 | Buy |
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Chemical Properties,Uses,Production
Description
Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.
Uses
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE is an inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.
Uses
An ureido-thiophenecarboxamide compound that acts as a potent inhibitor of IKK-2 (InhibitorVI).
IC 50
IKK-2: 25 nM (IC50)
References
[1] ANDREW BAXTER et al. et al. Hit-to-Lead Studies: The Discovery of Potent, Orally Active, Thiophenecarboxamide IKK-2 Inhibitors.[J]. ChemInform, 2004, 35 39. DOI: 10.1002/chin.200439220
[2] LUCY A MCNAMARA Kathleen L C Janani A Ganesh. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.[J]. Journal of Virology, 2012: 9337-9350. DOI: 10.1128/jvi.00895-12
[3] VASU PUNJ Preet M C Hittu Matta. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma.[J]. PLoS ONE, 2012: e37498. DOI: 10.1371/journal.pone.0037498
(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9541 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9548 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9482 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
