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[2H5]-Tiagabine hydrochloride

[2H5]-Tiagabine hydrochloride structure

CAS No.: 1253297-72-1

Chemical Name:: [2H5]-Tiagabine hydrochloride

Synonyms: Tiagabine hydrochloride salt;Tiagabine-[d5] hydrochloride;[2H5]-Tiagabine hydrochloride;Tiagabine-[D5] Hydrochloride (Standard);3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl-1,1,2,2,3-d5]-, hydrochloride (1:1), (3R)-

CBNumber:: CB08011318

Molecular Formula:: C20H20D5NO2S2.ClH

Molecular Weight:: 417.04

MDL Number:

MOL File:: 1253297-72-1.mol

Last updated:2025-04-18 09:51:22

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[2H5]-Tiagabine hydrochloride Properties

Melting point	182-185 °C(Solv: isopropanol (67-63-0))

[2H5]-Tiagabine hydrochloride Chemical Properties, Uses, Production

Uses

Tiagabine-d5 (hydrochloride) is deuterium labeled Tiagabine (hydrochloride). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47. DOI:10.1111/j.1471-4159.1990.tb01919.x
[3] Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40(3): p. 32-40. PMID:18007567
[4] Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50(2): p. 365-70. DOI:10.1016/j.neuint.2006.09.004

[2H5]-Tiagabine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

[2H5]-Tiagabine hydrochloride Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
Manhag Testing Technology Co., Ltd	400-818 0104 18918165978	yanyan.guo@bestown.net.cn	China	7770	58
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29128	58

Supplier	Advantage
Manhag Testing Technology Co., Ltd	58
TargetMol	58

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[2H5]-Tiagabine hydrochloride Tiagabine-[d5] hydrochloride Tiagabine hydrochloride salt 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl-1,1,2,2,3-d5]-, hydrochloride (1:1), (3R)- Tiagabine-[D5] Hydrochloride (Standard) 1253297-72-1