Alvimopan metabolite (ADL08-0011),hydrochloride salt
- CAS No.
- 170098-43-8
- Chemical Name:
- Alvimopan metabolite (ADL08-0011),hydrochloride salt
- Synonyms
- Alvimopan Impurity 21;ADL 08-0011 (hydrochloride);Alvimopan Metabolite 1 (ADL 08-0011) HCl;Alvimopan metabolite (ADL08-0011),hydrochloride salt;(3R,4R)-1-((2S)-2-Benzyl-2-carboxyethyl)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidine hydrochloride
- CBNumber:
- CB08020783
- Molecular Formula:
- C23H30ClNO3
- Molecular Weight:
- 403.95
- MDL Number:
- MOL File:
- 170098-43-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Alvimopan metabolite (ADL08-0011),hydrochloride salt Chemical Properties,Uses,Production
Uses
Alvimopan metabolite hydrochloride is a peripherally restricted Opioid Receptor antagonist that inhibits the amplitude of electrically evoked contractions and spontaneous mechanical activity in guinea pig ileum[1].
Biological Activity
ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan .1 It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.2
References
1.Beattie, D.T., Cheruvu, M., Mai, N., et al.The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexoneNaunyn Schmiedebergs Arch. Pharmacol.375(3)205-220(2007) 2.Armstrong, S.R., Campbell, C.B., Richardson, C.L., et al.The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activityNaunyn Schmiedebergs Arch Pharmacol.386(6)471-478(2013)
Alvimopan metabolite (ADL08-0011),hydrochloride salt Preparation Products And Raw materials
Raw materials
Preparation Products
Alvimopan metabolite (ADL08-0011),hydrochloride salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| Shenzhen Botel Biotechnology Co. Ltd. | 13316949107 13316968096 | 1979313431@qq.com | China | 9557 | 58 |
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| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
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| Hubei Rhema Reference Materials Technology Co., Ltd. | 15787879035 15787875101 | ydw9035@rmastandards.com | China | 9494 | 58 |
| Aoki Biotechnology (Shenzhen) Co., Ltd. | 18566777408 | CHINA | 156 | 58 |
