Bimagrumab
- CAS No.
- 1356922-05-8
- Chemical Name:
- Bimagrumab
- Synonyms
- Bimagrumab;Bimagrumab (anti-ACVR2B);Research Grade Bimagrumab;Research Grade Bimagrumab(DHD72801)
- CBNumber:
- CB08080877
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | N15SW1DIV8 |
| NCI Drug Dictionary | bimagrumab |
Bimagrumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0621493 | Bimagrumab 99.31% | 1356922-05-8 | 1mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-0621493 | Bimagrumab 99.31% | 1356922-05-8 | 5mg | $1083 | 2026-06-04 | Buy |
| ChemScene | CS-0621493 | Bimagrumab 99.31% | 1356922-05-8 | 10mg | $1733 | 2026-06-04 | Buy |
| ChemScene | CS-0621493 | Bimagrumab 99.31% | 1356922-05-8 | 25mg | $3142 | 2026-06-04 | Buy |
| Biorbyt Ltd | orb1290220 | Bimagrumab >95% | 100μg | $200 | 2026-05-06 | Buy |
Bimagrumab Chemical Properties, Uses, Production
Uses
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness[1][2].
in vivo
BYM338 (6-20 mg/kg; s.c. once weekly for 4 weeks) promotes an increase in body weight and skeletal muscle hypertrophy of all examined muscles, slow, fast, and mixed of young SCID mice[2].
BYM338 (5-20 mg/kg; s.c. once weekly for 14 d) prevents Glucocorticoid-induced muscle wasting in mice[2].
IC 50
ACVR2B: 1.7 pM (Kd); ACVR2A: 434 pM (Kd)
References
[1] Heymsfield SB, et, al. Effect of Bimagrumab vs Placebo on Body Fat Mass Among Adults With Type 2 Diabetes and Obesity: A Phase 2 Randomized Clinical Trial. JAMA Netw Open. 2021 Jan 4;4(1):e2033457. DOI:10.1001/jamanetworkopen.2020.33457
[2] Lach-Trifilieff E, et, al. An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy. Mol Cell Biol. 2014 Feb;34(4):606-18. DOI:10.1128/MCB.01307-13
Bimagrumab Preparation Products And Raw materials
Raw materials
Preparation Products
Bimagrumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Maixi Biotechnology Co., Ltd | 18007167883 18007167883 | Service@mabnus.com | China | 921 | 58 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10300 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27757 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7354 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4950 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 49531 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5579 | 58 |
