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ChemicalBook >> CAS DataBase List >>4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Structure
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- structure
CAS No.
1453099-83-6
Chemical Name:
4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
Synonyms
TAS-119;VIC-1911;TAS2104;TAS 2104;TAS-2104;VIC-1911 (TAS-119);TAS-119, 10 mM in DMSO;TAS119|||TAS2104|||TAS 2104|||TAS-2104|||TAS 119;4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-
CBNumber:
CB08101561
Molecular Formula:
C23H22Cl2FN5O3
Molecular Weight:
506.36
MDL Number:
MOL File:
1453099-83-6.mol
MSDS File:
SDS
Last updated:2026-05-27 22:52:14
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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Properties

storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (98.74 mM; Need ultrasonic)
form Solid
color White to off-white
FDA UNII 6A57J83J27

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth DIC09983 TAS-119 1453099-83-6 25mg $1382.75 2026-06-04 Buy
Biosynth DIC09983 TAS-119 1453099-83-6 50mg $1923.5 2026-06-04 Buy
ChemScene CS-0138153 TAS-119 98.01% 1453099-83-6 5mg $325 2026-06-04 Buy
ChemScene CS-0138153 TAS-119 98.01% 1453099-83-6 10mg $520 2026-06-04 Buy
ChemScene CS-0138153 TAS-119 98.01% 1453099-83-6 25mg $1029 2026-06-04 Buy
Product number Packaging Price Buy
DIC09983 25mg $1382.75 Buy
DIC09983 50mg $1923.5 Buy
CS-0138153 5mg $325 Buy
CS-0138153 10mg $520 Buy
CS-0138153 25mg $1029 Buy

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Chemical Properties, Uses, Production

Uses

TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites[1].

in vivo

TAS-119 (5-30 mg/kg; oral administration; twice daily on day 1 and everyday on day 2) treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts[1].

Animal Model:Nude rats injected with HeLa-luc cells[1]
Dosage:5 mg/kg, 10 mg/kg, and 30 mg/kg
Administration:Oral administration; twice daily on day 1 and everyday on day 2
Result:Induced pHH3 at all doses in nude rats with the HeLa-luc xenografts.

IC 50

Aurora A: 1 nM (IC50); Aurora B: 95 nM (IC50)

References

[1] Hiroshi Sootome, et al. Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes In Vitro and In Vivo: Preclinical Studies as Guidance for Clinical Development and Trial Design. Mol Cancer Ther. 2020 Oct;19(10):1981-1991. DOI:10.1158/1535-7163.MCT-20-0036

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Suppliers

Global Suppliers ( 37)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4858 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
SuZhou Medinoah Co.,LTD. 0512-69561983 13914027025 zhang_q@medinoah.com China 3925 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-13601744364 13601744364 chemsharker@126.com China 1162 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
SuZhou Medinoah Co.,LTD. 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
ShangHai ChuanQian Chemcial Technique Centre 58
Jinan Jiuli Biotechnology Co. , Ltd. 58

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- Spectrum

4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-(1453099-83-6)1HNMR

1453099-83-6 (4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-) Related Search:

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AT9283

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4-Piperidinecarboxylic acid, 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]- TAS 2104 TAS2104 TAS-2104 VIC-1911 (TAS-119) TAS119|||TAS2104|||TAS 2104|||TAS-2104|||TAS 119 TAS-119, 10 mM in DMSO TAS-119 VIC-1911 1453099-83-6 C23H22Cl2FN5O3 APIs