1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl-
![1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Structure](CAS/20200611/GIF/2413286-32-3.gif)
- CAS No.
- 2413286-32-3
- Chemical Name:
- 1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl-
- Synonyms
- SR-318;SR-318, 10 mM in DMSO;5-Amino-N-(4-((3-cyclohexylpropyl)carbamoyl)benzyl)-1-phenyl-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl-;anti-inflammatory,SR 318,TNFR,anti-cancer,p38 MAPK,Inhibitor,inhibit,whole,TNF Receptor,SR-318,SR318,p38α/β,Tumor Necrosis Factor Receptor,blood
- CBNumber:
- CB08201070
- Molecular Formula:
- C27H33N5O2
- Molecular Weight:
- 459.58
- MDL Number:
- MFCD32693911
- MOL File:
- 2413286-32-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Properties
| Boiling point | 732.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO:40.0(Max Conc. mg/mL);87.03(Max Conc. mM) |
| form | A solid |
| pka | 13.10±0.46(Predicted) |
| color | White to off-white |
| InChIKey | HXNUFFCHRIWTRZ-UHFFFAOYSA-N |
| SMILES | NC1=C(C(NCC2=CC=C(C(NCCCC3CCCCC3)=O)C=C2)=O)C=NN1C4=CC=CC=C4 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2839 | SR-318 ≥98% (HPLC) | 2413286-32-3 | 5 mg | $75.05 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2839 | SR-318 ≥98% (HPLC) | 2413286-32-3 | 25 mg | $302.6 | 2026-04-30 | Buy |
| Cayman Chemical | 34233 | SR 318 ≥98% | 2413286-32-3 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 34233 | SR 318 ≥98% | 2413286-32-3 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 34233 | SR 318 ≥98% | 2413286-32-3 | 10mg | $236 | 2026-04-30 | Buy |
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Chemical Properties, Uses, Production
Uses
SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1].
Biological Activity
SR-318 is a potent and selective type-II inhibitor th at targets p38α/β in an inactive DFG-out conformation with good kinome selectivity (p38α/β IC50 = 5/39 nM by radiometric kinase assay). SR-318 selectively inhibits p38α/β by cell-based NanoBRET assay (IC50 = 3.7 nM/p38α, 10 nM/p38β, 0.91 μM/ZAK, ≥3 μM/DDR1, DDR2, KIT, MYLK4, RSK4) and effectively blocks LPS-induced TNF-α release in human whole blood (IC50 = 283 nM). SR-321 is an inactive structural analog and the recommended negative control compound.
IC 50
p38α: 5 nM (IC50); p38β: 32 nM (IC50)
References
[1] Rhm S, et al. Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem. 2019 Dec 12;62(23):10757-10782. DOI:10.1021/acs.jmedchem.9b01227
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Shanghai Sunmonth Technology Co., LTD | 15216675652 | xuanyuelj@163.com | China | 3000 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
