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ChemicalBook >> CAS DataBase List >>1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- Structure
1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- structure
CAS No.
1039760-91-2
Chemical Name:
1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-
Synonyms
Rosolutamide;ASC-JM-17;1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-
CBNumber:
CB08243733
Molecular Formula:
C28H32O6
Molecular Weight:
464.55
MDL Number:
MOL File:
1039760-91-2.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- Properties

Boiling point 639.1±55.0 °C(Predicted)
Density 1.152±0.06 g/cm3(Predicted)
pka 9.19±0.59(Predicted)
form Solid
color Light yellow to yellow
FDA UNII 5VLL140BN9

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0644899 Rosolutamide ≥98.0% 1039760-91-2 1mg $238 2026-06-04 Buy
ChemScene CS-0644899 Rosolutamide ≥98.0% 1039760-91-2 5mg $596 2026-06-04 Buy
ChemScene CS-0644899 Rosolutamide ≥98.0% 1039760-91-2 10mg $937 2026-06-04 Buy
ChemScene CS-0644899 Rosolutamide ≥98.0% 1039760-91-2 25mg $1404 2026-06-04 Buy
aablocks AA02FCDQ ASC-JM-17 >98% 1039760-91-2 1mg $280 2026-06-03 Buy
Product number Packaging Price Buy
CS-0644899 1mg $238 Buy
CS-0644899 5mg $596 Buy
CS-0644899 10mg $937 Buy
CS-0644899 25mg $1404 Buy
AA02FCDQ 1mg $280 Buy

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- Chemical Properties, Uses, Production

Uses

Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby activating the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels[1][2].

IC 50

HSF1

References

[1] Laura C Bott, et al. A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy. Hum Mol Genet. 2016 May 15;25(10):1979-1989. DOI:10.1093/hmg/ddw073
[2] Yu-Ling Wu, et al. In Vitro Efficacy and Molecular Mechanism of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type 3. Antioxidants (Basel). 2022 Jul 18;11(7):1389. DOI:10.3390/antiox11071389

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- Preparation Products And Raw materials

Raw materials

Preparation Products

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rosolutamide pictures 2026-07-27 Rosolutamide
1039760-91-2
 $1080.00 99.15% 10g TargetMol Chemicals Inc.
  • Rosolutamide pictures
  • Rosolutamide
    1039760-91-2
  • $1080.00
  • 99.15%
  • TargetMol Chemicals Inc.

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- Spectrum

1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-(1039760-91-2)1HNMR

1039760-91-2 (1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)-) Related Search:

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Demethoxy Curcumin

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1,6-Heptadiene-3,5-dione, 4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)-, (1E,6E)- ASC-JM-17 Rosolutamide 1039760-91-2