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Ethylhexylglycerin

CAS No.
70445-33-9
Chemical Name:
Ethylhexylglycerin
Synonyms
Ethylhexyl Glecerine;Ethylhexylglycerine;3-(2-ethylhexyloxy)propane-1,2-diol;Sensiva SC 50;OCTOXYGLYCERIN;Ethyl hexyl glycerol;3-[2-(Ethylhexyl)oxyl]-1,2-propandiol;Lexgard E;3-[2-(EthyL;liquid,100Ml
CBNumber:
CB0854782
Molecular Formula:
C11H24O3
Molecular Weight:
204.31
MDL Number:
MFCD03790878
MOL File:
70445-33-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-05 19:35:02

Ethylhexylglycerin Properties

Boiling point 325°C
Density 0.962
refractive index 1.4490 to 1.4530
Flash point 152°C(lit.)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Oil
pka 13.67±0.20(Predicted)
color Colourless
Odor Characteristic
Cosmetics Ingredients Functions SKIN CONDITIONING
DEODORANT
Cosmetic Ingredient Review (CIR) Ethylhexylglycerin (70445-33-9)
InChI InChI=1S/C11H24O3/c1-3-5-6-10(4-2)8-14-9-11(13)7-12/h10-13H,3-9H2,1-2H3
InChIKey NCZPCONIKBICGS-UHFFFAOYSA-N
SMILES C(O)C(O)COCC(CC)CCCC
LogP 2.470 (est)
CAS DataBase Reference 70445-33-9
EWG's Food Scores 1
FDA UNII 147D247K3P

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318-H412
Precautionary statements  P501-P273-P280-P305+P351+P338+P310
Hazard Codes  Xi
Risk Statements  41-52/53
Safety Statements  26-39-61
RTECS  TY6462200
HS Code  2905399590
REACH Registrations Active
NFPA 704
1
2 0

Ethylhexylglycerin price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1044 3-(2-Ethylhexyloxy)-1,2-propanediol >98.0%(GC) 70445-33-9 25mL $87 2026-04-30 Buy
TCI Chemical E1044 3-(2-Ethylhexyloxy)-1,2-propanediol min. 98.0 % 70445-33-9 100ML $165 2026-03-19 Buy
TRC TRC-E918770-1G 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol >95%(GC) 70445-33-9 1g $298 2026-06-03 Buy
TRC TRC-E918770-10G 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol >95%(GC) 70445-33-9 10g $2169 2026-06-03 Buy
TRC TRC-E918770-100MG 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol >95%(GC) 70445-33-9 100mg $215 2026-06-03 Buy
Product number Packaging Price Buy
E1044 25mL $87 Buy
E1044 100ML $165 Buy
TRC-E918770-1G 1g $298 Buy
TRC-E918770-10G 10g $2169 Buy
TRC-E918770-100MG 100mg $215 Buy

Ethylhexylglycerin Chemical Properties, Uses, Production

Description

Ethylhexylglycerin is also named as 3-(2-Ethylhexoxy)propane-1,2-diol or octoxyglycerin. It is a glyceryl ether. It is used as a weak preservative, as skin conditioning agent with effective wetting ability. It is used with phenoxyethanol in cosmetics to obtain better protection against microbial growth.

Chemical Properties

Ethylhexylglycerin is a glycerol monoalkylether of defined structure and high purity,with a 2-ethylhexyl group bound to the primary hydroxyl function of the glycerol molecule. Due to the fact that it is a crystal-clear,colourless liquid with a slightly characteristic odour it is well suited for the use in cosmetic products. Although it is less soluble in water(<0.1% at 25℃),it is more easily soluble in most common cosmetic alcohols and glycols as well as oils.Ethylhexylglycerin is rather stable, e.g. against hydrolysis and elevated temperatures and compatible with cosmetic ingredients.
Ethylhexylglycerin is globally approved and as a new substance accords with the European legislation listed on the ELINCS file.
International Approvals
Europe / USA: INCl name: Ethylhexylglycerin
Australia: AICS/NICNAS(NA/966),TGA
Canada:DSL
Japan:
ENCS as glycerin monoalkyl(or alkenyl,C8-C24)ether(No.: 2-414)
CLS 199

Uses

Ethylhexylglycerin is a natural preservative, used as an alternative to parabens products. It is derived from natural glycerin. Also used as a deodorizer and skin conditioner.
Ethylhexylglycerin is a glyceryl ether and serves as an emollient solvent and a fixative with antimicrobial properties, and it is reported to enhance uptake of preservatives in microorganisms. It is often used as an alternative to parabens. The International Nomenclature of Cosmetic Ingredients name is Ethylhexylglycerin, and the chemical formula and synonym names are shown in Figure 1. Ethylhexylglycerin is a colorless to pale viscous liquid. It is reported to be used at a concentration up to 2% in leave-on products and 8% in rinse-off products. It is manufactured and marketed by Schu¨lke & Mayr GMBH, Norderstedt, Germany, under the trade name, Sensiva SC50, which is greater than 99% pure. Ethylhexylglycerin is found in many cosmetic products, that is, antiaging creams, sunscreens, eye shadows, eye creams, lip gloss, deodorants, facial moisturizers, and various types of cleansers.

Safety

With an EWG score of 1 and a rating of GOOD from Paula’s Choice, ethylhexylgylcerin is deemed to be very safe and a non-irritant.
Ethylhexylglycerin is a topical skin care ingredient and deodorizing agent, often indicated as a conditioning ointment in the treatment of eczema. It can also be a surfactant and preservative-enhancer and can be found as a substituent for parabens. Ethylhexylglycerin is commonly found in baby products or cosmetics marketed as “hypoallergenic” or “formaldehyde free”.
Ethylhexylglycerin has been reported to cause dermatitis and skin irritation.
www.cir-safety.org
What Is Ethylhexylglcerin & Is It Safe?

Toxicity evaluation

The oral toxicity of ethylhexylglycerin (Sensiva® SC 50, in polyethylene glycol 400) at doses of 100, 500, and 1,500 mg/kg was evaluated in a 28-day study using groups of 10 rats of an unspecified strain. The test substance was administered at a dose volume of 5 ml/kg.There were no treatment-related mortalities. Body weight development was retarded in mid- and high-dose groups, and this finding was accompanied by a non-statistically significant reduction in food intake when compared to the control (polyethylene glycol 400) group. Both eye and ear functions remained unchanged during the study, and increased salivation (dose not stated) was the only clinical symptom observed. Hematological parameters were unaffected by treatment; however, serum analyses indicated changes in aminotransferase (above normal) in high-dose rats. Urinalysis and necropsy findings were unremarkable.

Reference

W. Beilfuss, M. Leschke, K. Weber, A New Concept to Boost the Preservative Efficacy of Phenoxyethanol, SÖFW-Journal, 2005, vol. 131

Uses

Ethylhexylglycerin is the novel raw material for deodorants application and is widely used as a cosmetic emollient. Ethylhexylglycerin reliably inhibits the odor-causing bacteria, yeast and fungi on the skin.

Contact allergens

This glycerol monoalkylether is used as a skin conditioning agent, with bactericidal properties against Gram-positive bacteria.

Synthesis

Synthesis of ethylhexylglycerin is via the catalytic splitting of ethylhexylglycidyl ether followed by the addition of water. The product can then be purified by vacuum distillation.

104-76-7
96-24-2
70445-33-9
Synthesis of Ethylhexylglycerin from 2-Ethylhexanol and 3-Chloro-1,2-propanediol

Ethylhexylglycerin Preparation Products And Raw materials

Raw materials

Preparation Products

Global Suppliers ( 471)
Supplier Tel Email Country ProdList Advantage
Hubei ZhongKe XinChen Technology Ltd. 欢迎详询+微信 18827688560 starvips@qq.com China 496 58
Shanghai Synmedia Chemical Co., Ltd. 021-38681880 13817889927 sales@synmedia-chem.com China 249 58
Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd. 029-88380327 17691182729 1053@dideu.com China 2001 58
Wuhan Xingzhongcheng Technology Co., Ltd. 027-83389957 18627766980 914018854@qq.com China 290 58
Hangzhou Linran Biotechnology Co. LTD 0571-18067987-92 18067987892;13738142397 2543558860@qq.com China 137 58
Meite (Hubei) New Materials Co., Ltd 13517221830; 13517221830 18802755@qq.com China 2612 58
Nanjing LuoDa Chemical Co., Ltd 025-66016961 13382082786; China 276 55
Jiangyin Soteng Biotechnology Co., Ltd. 0510-86686637 13861630217 marketingb@suntonchem.com China 16 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Jiangsu Huayu Chemical Co., Ltd. 25-83241163 sales@elegantnutri.com China 55 55

Related articles

Related Questions

Ask a question
Q:Is ethylhexylglycerin safe for the skin?Anonymous - Aug 29,2025
A:No. Ethylhexylglycerin (CAS:70445-33-9) is an alkyl glycerol ether produced by the reaction of 2-ethylhexanol with glycerol. This ingredient is widely used in various cosmetics due to its combined properties as a surfactant, emollient, and its deodorising and antibacterial efficacy. Research confirms its ability to enhance the efficacy of preservatives and other antimicrobial agents (such as chlorhexidine gluconate and benzalkonium chloride) within alcohol-based hand sanitisers. However, ethylhexylglycerin is a highly relevant cosmetic allergen, even within products claiming safety. Although only a handful of cases of ethylhexylglycerin-induced allergic contact dermatitis (ACD) have been reported to date, primarily from cosmetics (including moisturisers, deodorants, and sunscreens), recent reports indicate that ethylhexylglycerin may also trigger occupational ACD in alcohol-based hand sanitiser formulations.

View Latest Price from Ethylhexylglycerin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-[2-(Ethylhexyl)oxyl]-1,2-propandiol pictures 2026-09-17 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol
70445-33-9
0.99 RongNa Biotechnology Co.,Ltd
Ethylhexylglycerin pictures 2026-09-17 Ethylhexylglycerin
70445-33-9
1kg/Drum ≥98% 50 T/Month Hebei Qujie Technology Co., Ltd.
3-[2-(Ethylhexyl)oxyl]-1,2-propandiol pictures 2026-09-17 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol
70445-33-9
$12.00 1kg 99% 500mt Jinan Finer Chemical Co., Ltd
2-Propanediol, 3-[(2-ethylhexyl)oxy]-1 Glycerol α-(2-Ethylhexyl) Ether Sensiva SC 50JP liquid,100Ml 3-(2-ethylhexyloxy) propane-1,2-dio Ethylhexyl Glycerin, (3-[2-(Ethylhexyl)Oxyl]-1,2-Propandiol) Sensiva SC 50 ETHYLHEXYLGLYCERIN 1,2-Propanediol, 3-(2-ethylhexyl)oxy- 3-[2-(Ethylhexyl)oxyl]-1,2-propandio 3-[2-(EthyL 3-(2-ethylhexoxy)propane-1,2-diol Ethyl hexyl glycerol Lexgard E 3-(2-Ethylhexyloxy)-1,2-propanediol > Glycerol Impurity 1 (Ethylhexylglycerin) ]-1,2-propandioL 2-Ethylhexylglycerin Glycerol alpha-(2-Ethylhexyl) Ether High Quality Ethylhexylglycerin CAS 70445-33-9 Ethylexylglycerin,3-[2-(Ethylhexyl)oxyl]-1,2-propandiol Octoxyglycerol Ethylehexylglycerin Glycerol Impurity 1 3-(2-ethylhexyloxy)propane-1,2-diol 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol Ethylhexyl Glecerine Ethylhexylglycerine OCTOXYGLYCERIN Ethylhexylglycerin / 3-(2-Ethylhexyloxy)-1,2-propanediol 70445-33-9 54464-57-6 70445-33-1 Aliphatics Intermediates & Fine Chemicals Pharmaceuticals 70445-33-9