Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)-
![Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- Structure](CAS/20210305/GIF/393794-17-7.gif)
- CAS No.
- 393794-17-7
- Chemical Name:
- Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)-
- Synonyms
- MLR24;MLR-24;MLR 24;Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)-
- CBNumber:
- CB08739166
- Molecular Formula:
- C28H24F3NO6
- Molecular Weight:
- 527.49
- MDL Number:
- MOL File:
- 393794-17-7.mol
- MSDS File:
- SDS
Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- Properties
| Boiling point | 585.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 30 mg/ml) |
| pka | 3.22±0.10(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0082973 | MRL-24 99.58% | 393794-17-7 | 5mg | $745 | 2026-06-04 | Buy |
| ChemScene | CS-0082973 | MRL-24 99.58% | 393794-17-7 | 10mg | $1192 | 2026-06-04 | Buy |
| ChemScene | CS-0082973 | MRL-24 99.58% | 393794-17-7 | 25mg | $2383 | 2026-06-04 | Buy |
| aablocks | AA023IF1 | MRL-24 >98% | 393794-17-7 | 5mg | $800 | 2026-06-01 | Buy |
| aablocks | AA023IF1 | MRL-24 >98% | 393794-17-7 | 10mg | $1258 | 2026-06-01 | Buy |
Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- Chemical Properties, Uses, Production
Description
MRL-24 (393794-17-7) displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. MRL-24 is highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of PPARγ. Cell permeable.
Uses
MRL-24 is a PPARγ agonist. MRL-24 can be used in metabolic disease related research[1].
IC 50
PPARγ
References
[1] WEBB P. Faculty Opinions recommendation of Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.[C]. 2010: 0. DOI:10.3410/f.4305956.4618058
Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- Preparation Products And Raw materials
Raw materials
Preparation Products
Propanoic acid, 2-[3-[[1-(4-methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl]methyl]phenoxy]-, (2S)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
