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veratramine

veratramine structure

CAS No.: 60-70-8

Chemical Name:: veratramine

Synonyms: NSC 2388;NSC 17821;NSC 23880;AIDS011940;veratraMin;Vreaframine;veratramine;Veratramine(P);Veratramine-RM;Veratramine, >99%

CBNumber:: CB0875482

Molecular Formula:: C27H39NO2

Molecular Weight:: 409.6

MDL Number:: MFCD00468124

MOL File:: 60-70-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:57:16

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veratramine Properties

Melting point	122-1240C
alpha	D25 -71.8° (c = 1.21); D25 -70° (c = 1.56 in methanol)
Boiling point	529.83°C (rough estimate)
Density	1.0393 (rough estimate)
refractive index	1.6400 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)
pka	14.82±0.60(Predicted)
form	solid
color	Tan
λmax	268nm(lit.)
Merck	14,9952
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey	MALFODICFSIXPO-KFKQDBFTSA-N
SMILES	N1C[C@@H](C)C[C@@H](O)[C@@H]1[C@H](C1=C(C)C2C[C@@]3([H])[C@]([H])(C=2C=C1)CC=C1C[C@@H](O)CC[C@]31C)C
CAS DataBase Reference	60-70-8
EWG's Food Scores	1
FDA UNII	RK363YG315

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P501-P270-P264-P301+P310+P330-P405

RIDADR

UN 2811 6.1/PG III

RTECS

YX5094000

HS Code

2933.39.4100

HazardClass

6.1

PackingGroup

III

Hazardous Substances Data

60-70-8(Hazardous Substances Data)

NFPA 704

	0
3		0

veratramine price More Price(73)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	V0148	Veratramine >98.0%(HPLC)	60-70-8	10mg	$36	2026-04-30	Buy
TCI Chemical	V0148	Veratramine >98.0%(HPLC)	60-70-8	50mg	$109	2026-04-30	Buy
Cayman Chemical	11724	Veratramine ≥95%	60-70-8	5mg	$43	2026-04-30	Buy
Cayman Chemical	11724	Veratramine ≥95%	60-70-8	10mg	$65	2026-04-30	Buy
Cayman Chemical	11724	Veratramine ≥95%	60-70-8	25mg	$151	2026-04-30	Buy

Product number	Packaging	Price	Buy
V0148	10mg	$36	Buy
V0148	50mg	$109	Buy
11724	5mg	$43	Buy
11724	10mg	$65	Buy
11724	25mg	$151	Buy

veratramine Chemical Properties, Uses, Production

Description

This alkaloid occurs naturally in Veratrum grandi/lorum and V. viride and is also formed during the hydrolysis of Veratrosine (q.v.). It forms colourless crystals of the monohydrate from aqueous EtOH and has [α]¹⁹_D - 70° (MeOH). The hydrochloride forms colourless plates from EtOH, m.p. 20l-2°C and the picrate, yellow plates, m.p. 217.5 - 218°C. Two non-phenolic hydroxyl groups and an imino group are present and the triacetyl derivative, m.p. 205.5-206°C; [α]^14.5_D + 37.8° (MeOH), on controlled hydrolysis furnishes the N-acetyl com_x0002_pound, m.p. 176-8°C. The O-acetate has also been prepared as colourless prisms from aqueous EtOH, m.p. 20l-2°C but it is still uncertain which of the hydroxyl groups is acetylated in this derivative. Treatment with methyl iodide in MeOH in the presence of sodium carbonate gives N-methylveratraminc methiodide, m.p. 268°C (dec.) from which the methochloride, m.p. 277°C can be obtained. On catalytic hydrogenation, the base furnishes the dihydro derivative, m.p. 198- 200°C; [α]²⁷_D + 27.4°, which forms the N-acetyl compound, m.p. 220-3°C; [α]²⁸_D + 81° and the triacetyl derivative, m.p. l89.5-190.5°C; [α]²⁴_D + 84°.

Chemical Properties

White Solid

Uses

It is useful as signal transduction inhibitor for treating tumors

Uses

The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine , plays a key role in morphogenesis and has potential applications in the treatment of cancer. Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM. Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.

Definition

ChEBI: A piperidine alkaloid comprising the 14,15,16,17-tetradehydro derivative of veratraman having two hydroxy groups at the 3- and 23-positions.

References

Saito., Bull. Chem. Soc., Japan, 15, 22 (1940)
Jacobs, Craig.,J. Biol. Chem., 155,565 (1944)
Jacobs,.Craig., ibid, 160,555 (1945)
Tamm, Wintersteiner., J. Amer. Chem. Soc., 74,3842 (1952)
Mass spectra: Budzikiwicz., Tetrahedron, 20,2267 (1964)
Synthesis: Masamune, Takasugi, Murai., Tetrahedron, 27,3369 (1971)

veratramine Preparation Products And Raw materials

Raw materials

Preparation Products

veratramine Suppliers

Global Suppliers ( 212)

Supplier	Tel	Email	Country	ProdList	Advantage
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
ShangHai YuanYe Biotechnology Co., Ltd.	15026964105	shyysw007@163.com	China	4998	60
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60
Shanghai Winherb Medical Technology Co., Ltd.	17301719108 13341702378	winherb@126.com	China	1245	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80

Supplier	Advantage
Chembest Research Laboratories Limited	61
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
Chemsky（shanghai）International Co.,Ltd.	50
BioBioPha Co., Ltd.	65
ShangHai YuanYe Biotechnology Co., Ltd.	60
Chengdu Biopurify Phytochemicals Ltd.	60
Shanghai Winherb Medical Technology Co., Ltd.	58
Haoyuan Chemexpress Co., Ltd.	61
TOKYO CHEMICAL INDUSTRY CO., LTD.	80

View Latest Price from veratramine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	veratramine 60-70-8		10MG	98% HPLC	1000KG	Changsha Staherb Natural Ingredients Co., Ltd.
2023-02-24	Veratramine 60-70-8		5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2022-02-14	Veratramine 60-70-8 60-70-8	$45.00	10mg	≥98% HPLC	1000.00 kgs	NanJing Spring & Autumn Biological Engineering CO., LTD.

veratramine
60-70-8
$0.00
98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Veratramine
60-70-8
$0.00
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Veratramine 60-70-8
60-70-8
$45.00
≥98% HPLC
NanJing Spring & Autumn Biological Engineering CO., LTD.

veratramine Spectrum

veratramine(60-70-8)¹HNMR

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veratramine Vreaframine (3b,23b)-14,15,16,17-Teradehydroveratraman-3,23-diol NSC 17821 NSC 2388 Veratramine (NSC17821 Veratramine, >99% Veratramine 60-70-8 NSC17821;NSC23880 AIDS011940 (3,23)-14,15,16,17-Teradehydroveratraman-3,23-diol NSC 23880 14,15,16,17-Tetradehydroveratraman-3β,23β-diol veratraMin (2S,3R,5S)-5-Methyl-2-[(1S)-1-[(3S,6aR,11aS,11bR)-2,3,4,6,6a,11,11a,11b-octahydro-3-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-3-piperidinol Veratramine (NSC-23880) Veratramine, 98%, from Veratrum nigrum L. 5S-methyl-2S-[1S-[2,3S,4,6,6aR,11,11aS,11bR-octahydro-3R-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-3-piperidinol Veratramine Veratramine 3-Piperidinol, 5-methyl-2-[(1S)-1-[(3S,6aR,11aS,11bR)-2,3,4,6,6a,11,11a,11b-octahydro-3-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-, (2S,3R,5S)- (2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol (2S,3R,5S)-2-((S)-1-((3S,6aR,11aS,11bR)-3-Hydroxy-10,11b-dimethyl-2,3,4,6,6a,11,11a,11b-octahydro-1H-benzo[a]fluoren-9-yl)ethyl)-5-methylpiperidin-3-ol Veratramine(P) Veratramine-RM Veratramine, 10 mM in DMSO Veratramine (Standard) 60-70-8 CH3O2C6H3CH2NH2 C27H39NO2 Alkaloids Intermediates & Fine Chemicals Pharmaceuticals