4-methyl hydrogen D-aspartate hydrochloride
- CAS No.
- 22728-89-8
- Chemical Name:
- 4-methyl hydrogen D-aspartate hydrochloride
- Synonyms
- (R)-2-Amino-4-methoxy-4-oxobutanoic acid hydrochloride;B-methylesterD-aspartateHCl;BETA-METHYLESTER-D-ASPARTATEHCL;B-methylesterD-aspartatehydrochloride;β-Methyl (2R)-aspartate ester hydrochloride;4-methyl hydrogen D-aspartate hydrochloride;D-Aspartic acid-b-methyl ester hydrochloride;(2R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride;D-Aspartic Acid 4-Methyl Ester Hydrochloride D-Aspartic Acid 4-Methyl Ester Hydrochloride
- CBNumber:
- CB0884817
- Molecular Formula:
- C5H11ClNO4
- Molecular Weight:
- 184.59814
- MDL Number:
- MOL File:
- 22728-89-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
4-methyl hydrogen D-aspartate hydrochloride price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 445511 | D-Aspartic Acid 4-Methyl Ester Hydrochloride | 22728-89-8 | 1g | $403 | 2026-06-03 | Buy |
| Usbiological | 445511 | D-Aspartic Acid 4-Methyl Ester Hydrochloride | 22728-89-8 | 10g | $531 | 2026-06-03 | Buy |
| Biosynth | XAA72889 | D-Aspartic Acid 4-Methyl Ester Hydrochloride | 22728-89-8 | 25g | $590 | 2026-06-05 | Buy |
| aablocks | AA00BFZS | D-Aspartic acid-b-methyl ester hydrochloride 97% | 22728-89-8 | 1g | $11 | 2026-05-28 | Buy |
| aablocks | AA00BFZS | D-Aspartic acid-b-methyl ester hydrochloride 97% | 22728-89-8 | 5g | $16 | 2026-05-28 | Buy |
4-methyl hydrogen D-aspartate hydrochloride Chemical Properties, Uses, Production
Uses
D-Aspartic acid 4-methyl ester is a protected form of D-Aspartic acid (A790020). D-Aspartic acid is the unnatural isomer of L-Aspartic acid (A790024). D-Aspartic acid naturally occurs in human ovarian follicular fluid, and is thought to be linked to oocyte quality. It is also found in the white matter of human brains, more specifically in myelin proteins.
Synthesis
67-56-1
1783-96-6
22728-89-8
The general procedure for the synthesis of (R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride from methanol and D-aspartic acid was as follows: D-aspartic acid (160 g, 1.2 mol) was suspended in 850 mL of methanol and cooled to -5 to 0°C. Thionyl chloride (178.4 g, 1.5 mol) was added slowly dropwise with stirring. After completion of the dropwise addition, the reaction mixture was slowly warmed to 25 to 35°C and the reaction was continued with stirring for 4 to 5 hours. Upon completion of the reaction, the methanol was removed by distillation under reduced pressure. The resulting white solid was washed with stirring in 500 mL of ethyl acetate for 0.5 h. Subsequent filtration and drying afforded the target product (R)-2-amino-4-methoxy-4-oxobutanoic acid hydrochloride (Compound of Formula II) 192 g in 87% yield with a melting point of 185 to 186°C. The reaction mixture was slowly warmed to 25 to 35°C for 4 to 5 hours.
References
[1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 17, p. 2513 - 2526
[2] Patent: CN103992337, 2016, B. Location in patent: Paragraph 0031; 0032
[3] Patent: CN104497010, 2016, B. Location in patent: Paragraph 0035; 0036; 0037
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 5, p. 674 - 688
4-methyl hydrogen D-aspartate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-methyl hydrogen D-aspartate hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| YangZhou Ruihong Biotech Co., Ltd. | 0514-015380367604 15380367604 | sales@ruibobiotech.com | China | 509 | 55 |
| Chengdu Chuangkecheng Biological Technology Co., Ltd. | 028-028-0000000 13008177686 | sales@ckcbiotech.com | China | 899 | 55 |
| Shanghai GL Peptide Ltd. | +86-21-61263310 13764994101 | fisherwang@glschina.com | China | 8059 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Wuxi Asia Peptide Biotechnology Limited Company | 0510-83583050 13771062561 | willsun@peptide-search.com | China | 6713 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
