ChemicalBook >> CAS DataBase List >>5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-

5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-

5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- structure

CAS No.: 2267290-96-8

Chemical Name:: 5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-

Synonyms: QC-01–175;N-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl];N-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide;N-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-5H-pyrido[4,3-b]indole-7-propanamide;5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-

CBNumber:: CB09308174

Molecular Formula:: C33H34N6O7

Molecular Weight:: 626.66

MDL Number:

MOL File:: 2267290-96-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:30

Request For Quotation

5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- Properties

Boiling point	977.2±65.0 °C(Predicted)
Density	1.416±0.06 g/cm3(Predicted)
form	Solid
pka	10.74±0.40(Predicted)
color	Light yellow to green yellow

5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0159800	QC-01–175 99.94%	2267290-96-8	5mg	$217	2026-06-04	Buy
ChemScene	CS-0159800	QC-01–175 99.94%	2267290-96-8	10mg	$314	2026-06-04	Buy
ChemScene	CS-0159800	QC-01–175 99.94%	2267290-96-8	25mg	$563	2026-06-04	Buy
ChemScene	CS-0159800	QC-01–175 99.94%	2267290-96-8	50mg	$845	2026-06-04	Buy
ChemScene	CS-0159800	QC-01–175 99.94%	2267290-96-8	100mg	$1267	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0159800	5mg	$217	Buy
CS-0159800	10mg	$314	Buy
CS-0159800	25mg	$563	Buy
CS-0159800	50mg	$845	Buy
CS-0159800	100mg	$1267	Buy

5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- Chemical Properties, Uses, Production

Description

QC-01-175 targets ZFP91, ZN653, ZN827 also degraded at 4 h, 1 μM in patient iPSC derived FTD neurons harboring MAPT A152T mutation.

Uses

QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2].

References

[1] Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457. DOI:10.7554/eLife.45457
[2] Tiziana Petrozziello, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan;59(1):683-702. DOI:10.1007/s12035-021-02557-w

5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1644	58
DC Chemicals	021-58447131 13564518121	doncunbiosci@gmail.com	China	618	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5987	58

Supplier	Advantage
Shanghai Chaolan Chemical Technology Center	58
Jilin Province Woda Biotechnology Co., Ltd.	58
DC Chemicals	58
Nantong QuanYi Biotechnology Co., Ltd	58

2267290-96-8 (5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-) Related Search:

dTAGV-1 CC-94676 Anti-Aging Compound Library DT2216 Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

AU-15330

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5H-Pyrido[4,3-b]indole-7-propanamide, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]- N-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl] QC-01–175 N-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-3-(5H-pyrido[4,3-b]indol-7-yl)propanamide N-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-5H-pyrido[4,3-b]indole-7-propanamide 2267290-96-8 C33H34N6O7