dTAGV-1
- CAS No.
- 2624313-15-9
- Chemical Name:
- dTAGV-1
- Synonyms
- dTAGV-1 TFA;dTAGV-1;(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate 2,2,2-trifluoroacetate
- CBNumber:
- CB010684502
- Molecular Formula:
- C68H90N6O14S.C2HF3O2
- Molecular Weight:
- 1361.57
- MDL Number:
- MOL File:
- 2624313-15-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
dTAGV-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0375590 | dTAGV-1 TFA 99.92% | 2624313-15-9 | 1mg | $195 | 2026-06-04 | Buy |
| ChemScene | CS-0375590 | dTAGV-1 TFA 99.92% | 2624313-15-9 | 5mg | $487 | 2026-06-04 | Buy |
| ChemScene | CS-0375590 | dTAGV-1 TFA 99.92% | 2624313-15-9 | 10mg | $829 | 2026-06-04 | Buy |
| ChemScene | CS-0375590 | dTAGV-1 TFA 99.92% | 2624313-15-9 | 25mg | $1733 | 2026-06-04 | Buy |
| ChemScene | CS-0375590 | dTAGV-1 TFA 99.92% | 2624313-15-9 | 50mg | $2925 | 2026-06-04 | Buy |
dTAGV-1 Chemical Properties, Uses, Production
Uses
dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo[1].
in vivo
dTAGV-1 (35 mg/kg; i.p. once daily for 4 days) TFA induces degradation of FKBP12F36V-Nluc in mice[1].
dTAGV-1 (2-10 mg/kg; i.p.) TFA exhbits half-lives (T1/2=3.64 and 4.4 h), Cmax (595 and 2123 ng/mL) and great exposure (AUCinf=3136 and18517 hng/mL) in mice[1].
dTAGV-1 (2 mg/kg; i.v.) TFA exhbits half-life (T1/2=3.02 h), Cmax (7780 ng/mL) and great exposure (AUCinf=3329 hng/mL) in mice[1].
| Animal Model: | 8-week-old immunocompromised female mice were transplanted with MV4;11 luc-FKBP12F36V cells[1] |
| Dosage: | 35 mg/kg |
| Administration: | I.p. once daily for 4 days |
| Result: | Observed striking loss of bioluminescent signal 4h after the first and three administrations. Degradation evident 28h after the final administration. |
IC 50
VHL
storage
Store at -20°C
References
[1] Nabet B, et, al. Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat Commun. 2020 Sep 18;11(1):4687. DOI:10.1038/s41467-020-18377-w
dTAGV-1 Preparation Products And Raw materials
Raw materials
Preparation Products
dTAGV-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 473 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Suzhou Hosyn Pharm Ltd. | 17621975170; 17621975170 | sales@hosynpharm.com | China | 1721 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38904 | 58 |
| SuZhou GoodChemTech Co., Ltd | 18136139868; 18136139868 | jinlun@goodchemtech.cn | China | 321 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| Aikon International Limited | 025-58859352 18651614124 | 2881516338@qq.com | China | 9968 | 58 |
| Shanghai Anbida Biotechnology Co., Ltd. | 021-61629020 18201956406 | sales@ambeed.cn | China | 7032 | 58 |
