methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate
- CAS No.
- 874649-82-8
- Chemical Name:
- methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate
- Synonyms
- TRC-CANADA;methyl 6-fluorochroman-2-carboxylate;Methyl 6-fluorochromane-2-carboxylate;6-Fluorochroman-2-carboxylic Acid Methyl Ester;methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate;Methyl 6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylate;Methyl 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate;6-Fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid methyl ester;6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid Methyl Ester;2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-, methyl ester
- CBNumber:
- CB0970941
- Molecular Formula:
- C11H11FO3
- Molecular Weight:
- 210.2
- MDL Number:
- MFCD09701969
- MOL File:
- 874649-82-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 48 °C |
|---|---|
| Boiling point | 286.8±40.0 °C(Predicted) |
| Density | 1.242±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Dichloromethane, Methanol |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | InChI=1S/C11H11FO3/c1-14-11(13)10-4-2-7-6-8(12)3-5-9(7)15-10/h3,5-6,10H,2,4H2,1H3 |
| InChIKey | QAYAXMIKHJVIJM-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)OC2=CC=C(F)C=C2CC1 |
| CAS DataBase Reference | 874649-82-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2932.99.9090 |
| REACH Registrations | Active |
methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2879 | Methyl 6-Fluorochroman-2-carboxylate >98.0%(GC) | 874649-82-8 | 1g | $31 | 2026-04-30 | Buy |
| TCI Chemical | M2879 | Methyl 6-Fluorochroman-2-carboxylate >98.0%(GC) | 874649-82-8 | 5g | $109 | 2026-04-30 | Buy |
| TRC | TRC-F591015-50MG | rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid Methyl Ester | 874649-82-8 | 50mg | $161 | 2026-06-03 | Buy |
| TRC | TRC-F591015-250MG | rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid Methyl Ester | 874649-82-8 | 250mg | $467 | 2026-06-03 | Buy |
| TRC | TRC-F591015-100MG | rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid Methyl Ester | 874649-82-8 | 100mg | $199 | 2026-06-03 | Buy |
methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate Chemical Properties,Uses,Production
Uses
Intermediate in the preparation of hydroxylated Nebivolol metabolites.
Synthesis
99199-59-4
75-75-2
874649-82-8
Example 2 Synthesis of methyl 6-fluoro-1-benzopyran-2-carboxylate: 20 g of 6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid (96 mmol) was mixed with 2 g of methanesulfonic acid (20 mmol) and 2 g of 5% Pd/C catalyst (Escat 112 type, Engelhard) in THF at 45-55°C under 4 bar of hydrogen pressure The hydrogenation reaction was carried out until the consumption of hydrogen stopped. The reaction progress was monitored by TLC. Upon completion of the reaction, the catalyst was removed by filtration and the reaction mixture was concentrated under reduced pressure to 40 ml. Subsequently, 100 ml of methanol was added and the mixture was stirred at 20-25 °C until the TLC assay showed less than 1% of 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid. Next, the solution was concentrated under reduced pressure, the residue was dissolved in 60 ml of THF and concentrated again under reduced pressure and the water was removed by azeotropic distillation. Finally 20 g of methyl 6-fluorochroman-2-carboxylate was obtained (yield: 100%). δH (400 MHz; CDCl3) 6.89-6.79 (2H, m, Ar), 6.77-6.76-6.72 (1H, m, Ar), 4.73-4.69 (1H, m), 3.79 (3H, s), 2.87-2.69 (2H, m) , 2.31-2.12 (2H, m).
References
[1] Patent: US2011/237808, 2011, A1. Location in patent: Page/Page column 5
methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2283 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| shanghai cooperpharm co.,LTD . | +86-021-58975553 | sales@cooperpharm.com | China | 1210 | 56 |
View Lastest Price from methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate
874649-82-8
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate
874649-82-8
- $6.68
- 97%-99%
- Career Henan Chemical Co
