TCS 359
- CAS No.
- 301305-73-7
- Chemical Name:
- TCS 359
- Synonyms
- TCS359;CS-1153;TCS359; TCS-359;Flt-3 inhibitor;TCS 359 USP/EP/BP;TCS 359, 10 mM in DMSO;Flt-3 Inhibitor TCS359 TCS-359;2-(3,4-DIMETHOXY-BENZOYLAMINO)-4,5,6,7-T;Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem;TCS 359, FLT3 receptor tyrosine kinase inhibitor
- CBNumber:
- CB0973098
- Molecular Formula:
- C18H20N2O4S
- Molecular Weight:
- 360.43
- MDL Number:
- MFCD00617269
- MOL File:
- 301305-73-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 454.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.328±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | H2O: <2mg/mL |
| pka | 12.43±0.20(Predicted) |
| form | White solid |
| color | white to off-white |
| Water Solubility |
H2O: <2mg/mL DMSO: ~8mg/mL |
| Sensitive | Light Sensitive |
| InChI | 1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22) |
| InChIKey | FSPQCTGGIANIJZ-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O |
| CAS DataBase Reference | 301305-73-7 |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P302+P352-P305+P351+P338-P321-P405-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934.99.4400 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
TCS 359 price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D5943 | 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide ≥98% (HPLC), solid | 301305-73-7 | 5mg | $246 | 2026-04-30 | Buy |
| Sigma-Aldrich | 343020 | Flt-3 Inhibitor | 301305-73-7 | 5mg | $229 | 2026-04-30 | Buy |
| TCI Chemical | D5275 | TCS 359 >98.0%(HPLC) | 301305-73-7 | 25mg | $100 | 2026-04-30 | Buy |
| TCI Chemical | D5275 | TCS 359 >98.0%(HPLC) | 301305-73-7 | 100mg | $299 | 2026-04-30 | Buy |
| Cayman Chemical | 18462 | FLT3 Inhibitor ≥98% | 301305-73-7 | 5mg | $69 | 2026-04-30 | Buy |
TCS 359 Chemical Properties, Uses, Production
Uses
Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer. FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 μM). It is selective for FLT3 over a panel of 22 other kinases. FLT3 Inhibitor synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.
Uses
TCS 359 is a potent inhibitor of FLT3 used in the treatment of leukemia.
Definition
ChEBI: 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide is a dimethoxybenzene.
Biological Activity
Potent inhibitor of FLT3 receptor tyrosine kinase (IC 50 = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukaemia cell line expressing a constitutively active mutant FLT3 (IC 50 = 340 nM).
storage
Store at +4°C
References
[1]. trzci′nska-daneluti a.m., nguyen l., jiang c., et al. use of kinase inhibitors to correct δf508-cftr function. molecular & cellular proteomics, 2012, 11(9):745-757.
[2]. patch r.j., baumann c.a., liu j., et al. identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of flt3. bioorganic & medicinal chemistry letters, 2006, 16: 3282-3286.
[3]. kar r.k., suryadevara p., roushan r., et al. quantifying the structural requirements for designing newer flt3 inhibitors. medicinal chemistry, 2012, 8:913-927.
[4]. nishijima c., kawamura k., okamoto n., et al. regulation of preimplantation embryo development in mice by fms-like tyrosine kinase 3 ligand. journal of mammalian ova research, 2014, 31(1):45-51.
[5]. o'farrell a.m., yuen h.a., smolich b., et al. effects of su5416, a small molecule tyrosine kinase receptor inhibitor, on flt3 expression and phosphorylation in patients with refractory acute myeloid leukemia. leuk. res., 2004, 28(7):679-89.
TCS 359 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Jinan Bond Chemical Technology Co., Ltd. | 86-531-88280989 | mymail1996@126.com | China | 254 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
