3-Hydroxy-5-methyl-benzoic acid
- CAS No.
- 585-81-9
- Chemical Name:
- 3-Hydroxy-5-methyl-benzoic acid
- Synonyms
- Aids018040;Aids-018040;3,5-Cresotic acid;-Hydroxy-5-methylbenzoic acid;3-hydrox-5-methylbenzoic acid;3-Hydroxy-5-methyl-benzoic acid;Benzoic acid, 3-hydroxy-5-methyl-;3-HYDROXY-5-METHYL-BENZOIC ACID 97%
- CBNumber:
- CB11010373
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD09833213
- MOL File:
- 585-81-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2916399090 |
3-Hydroxy-5-methyl-benzoic acid price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 278777 | 3-Hydroxy-5-methylbenzoic acid Asreported | 585-81-9 | 5g | $1288 | 2026-06-03 | Buy |
| Usbiological | 278777 | 3-Hydroxy-5-methylbenzoic acid Asreported | 585-81-9 | 10g | $1656 | 2026-06-03 | Buy |
| Usbiological | 278777 | 3-Hydroxy-5-methylbenzoic acid Asreported | 585-81-9 | 25g | $2248 | 2026-06-03 | Buy |
| Usbiological | 278777 | 3-Hydroxy-5-methylbenzoic acid Asreported | 585-81-9 | 50g | $3805 | 2026-06-03 | Buy |
| Usbiological | 278777 | 3-Hydroxy-5-methylbenzoic acid Asreported | 585-81-9 | 100g | $6476 | 2026-06-03 | Buy |
3-Hydroxy-5-methyl-benzoic acid Chemical Properties, Uses, Production
Chemical Properties
White powder
Uses
3,5-Cresotic Acid is a reactant used in the preparation of trisubstituted benzenes as thrombin inhibitors for the treatment of coagulation disorders.
Synthesis
100118-65-8
585-81-9
General procedure for the synthesis of 3-hydroxy-5-methylbenzoic acid from the compound (CAS:100118-65-8): the oxo compound (57 g, 0.21 mol) was added to water (450 mL) together with magnesium oxide (38.1 g, 0.945 mol). The reaction mixture immediately changed to a dark reddish-orange color, followed by a gradual change to a light brown color over about 15 minutes. After continuous stirring and heating for 30 minutes, the excess magnesium oxalate and magnesium oxide were removed by filtration. The residue was washed with warm water, the filtrates were combined and concentrated by distillation under vacuum to about 30 mL. The concentrate was slowly added to a mixture consisting of concentrated hydrochloric acid and water (1:1, v/v, 50 mL), whereupon a precipitate was produced. The precipitate was filtered, washed with cold water and dried. Finally, purification by recrystallization in water afforded 3-hydroxy-5-methylbenzoic acid as a light brown solid (13.43 g, 42% yield). Melting point: 202-203 °C (literature value 207-208 °C); 1H NMR (D2O) δ: 2.19 (s, 3H), 6.82 (s, 1H), 7.07 (s, 1H), 7.20 (s, 1H); 13C NMR (D2O) δ: 20.20, 113.00, 121.03, 122.25, 130.65, 140.55, 155.34, 170.26.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 16, p. 4720 - 4723
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5622 - 5626
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 11, p. 3961 - 3973
[4] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 7, p. 1848 - 1858
[5] Patent: US2011/15395, 2011, A1. Location in patent: Page/Page column 13
3-Hydroxy-5-methyl-benzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
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