4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid ethyl ester
- CAS No.
- 50920-64-4
- Chemical Name:
- 4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid ethyl ester
- Synonyms
- Ethyl 2-ethyl-5-methylpyrazole-3-carboxylate;Ethyl 1-ethyl-3-methylpyrazole-5-carboxylate;1H-Pyrazole-5-carboxylic acid, 1-ethyl-3-methyl-, ethyl ester
- CBNumber:
- CB11013147
- Molecular Formula:
- C9H14N2O2
- Molecular Weight:
- 182.22
- MDL Number:
- MFCD00159650
- MOL File:
- 50920-64-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H412-H227 |
| Precautionary statements | P501-P273-P260-P270-P262-P210-P271-P264-P280-P284-P370+P378-P361+P364-P301+P310+P330-P302+P352+P310-P304+P340+P310-P403+P233-P403+P235-P405 |
| HS Code | 2933199090 |
4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid ethyl ester price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR300543 | Ethyl 2-ethyl-5-methylpyrazole-3-carboxylate 95% | 50920-64-4 | 1g | $130 | 2026-06-04 | Buy |
| aablocks | AA00DG5L | Ethyl 1-ethyl-3-methyl-1H-pyrazole-5-carboxylate 98% | 50920-64-4 | 250mg | $6 | 2026-05-28 | Buy |
| aablocks | AA00DG5L | Ethyl 1-ethyl-3-methyl-1H-pyrazole-5-carboxylate 98% | 50920-64-4 | 1g | $17 | 2026-05-28 | Buy |
| ACHEMBLOCK | W157957 | Ethyl 2-ethyl-5-methylpyrazole-3-carboxylate 97% | 50920-64-4 | 5G | $135 | 2026-05-27 | Buy |
| ACHEMBLOCK | W157957 | Ethyl 2-ethyl-5-methylpyrazole-3-carboxylate 97% | 50920-64-4 | 25G | $540 | 2026-05-27 | Buy |
4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid ethyl ester Chemical Properties,Uses,Production
Synthesis
50920-65-5
64-17-5
50920-64-4
Oxalyl chloride (5.68 mL, 64.9 mmol) was slowly added dropwise to a suspension of 1-ethyl-3-methyl-1H-pyrazole-5-carboxylic acid (5 g, 32.4 mmol) dissolved in dichloromethane (40 mL) at room temperature and two drops of N,N-dimethylformamide (DMF) were added as catalyst. The reaction mixture was stirred at room temperature for 2 h, subsequently concentrated by rotary evaporator and dried under vacuum. Anhydrous ethanol (50 mL, 856 mmol) was added to the resulting residue and the reaction mixture continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was again concentrated by rotary evaporator and dried under vacuum. The light yellow oil obtained was dissolved in ethyl acetate (100 mL), washed sequentially with saturated sodium bicarbonate solution and brine, and the organic phase was dried with anhydrous sodium sulfate, filtered, and concentrated. Finally, the residue was dried under vacuum to give ethyl 3-methyl-1-ethyl-1H-pyrazole-5-carboxylate (5.5 g, 30.2 mmol, 93% yield) as a light yellow oil. The product was characterized by 1H NMR (400 MHz, chloroform-d) and LCMS (LCMS method E): 1H NMR δ 6.63 (s, 1H), 4.56 (q, J = 7.11 Hz, 2H), 4.35 (q, J = 7.11 Hz, 2H), 2.30 (s, 3H), 1.44 (t, J = 7.28 Hz, 3H), 1.39 (t, J = 7.28 Hz, 3H); LCMS Rt = 0.81 min, [M + H]+ = 183.1.
References
[1] Patent: WO2017/175147, 2017, A1. Location in patent: Page/Page column 191
4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid ethyl ester Suppliers
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