Ethyl 3-methyl-1H-pyrazole-5-carboxylate
- CAS No.
- 4027-57-0
- Chemical Name:
- Ethyl 3-methyl-1H-pyrazole-5-carboxylate
- Synonyms
- 1H-Pyrazole-3-carboxylic acid, 5-methyl-, ethyl ester;5-Methyl-1H-pyrazole-3-carboxylic acid ethyl ester;AKOS PAO-0427;BUTTPARK 29\06-79;3-methylpyrazole-5-ethyl formate;3-Ethoxycarbonyl-5-methylpyrazole;ETHYL 3-METHYLPYRAZOLE-5-CARBOXYLATE;ETHYL 3-METHYL-5-PYRAZOLECARBOXYLATE;Ethyl 5-methylpyrazole-3-carboxylate;Ethyl3-Methylpyrazole-5-carboxylate>
- CBNumber:
- CB5360136
- Molecular Formula:
- C7H10N2O2
- Molecular Weight:
- 154.17
- MDL Number:
- MFCD00052514
- MOL File:
- 4027-57-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl 3-methylpyrazole-5-carboxylate 98% | 558354 | 5g | $64.8 |
| Ethyl 3-Methylpyrazole-5-carboxylate >98.0%(GC) | E1100 | 1g | $24 |
| Ethyl 3-Methylpyrazole-5-carboxylate >98.0%(GC) | E1100 | 5g | $78 |
| Ethyl 3-Methyl-5-pyrazolecarboxylate | 449124 | 5g | $403 |
| Ethyl 3-Methyl-5-pyrazolecarboxylate | 449124 | 25g | $785 |
| More product size | |||
| Melting point | 80-84 °C (lit.) |
|---|---|
| Boiling point | 299.1±20.0 °C(Predicted) |
| Density | 1.171±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 11.60±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| BRN | 4192 |
| InChI | InChI=1S/C7H10N2O2/c1-3-11-7(10)6-4-5(2)8-9-6/h4H,3H2,1-2H3,(H,8,9) |
| InChIKey | BOTXQJAHRCGJEG-UHFFFAOYSA-N |
| SMILES | N1C(C)=CC(C(OCC)=O)=N1 |
| CAS DataBase Reference | 4027-57-0(CAS DataBase Reference) |
| FDA UNII | 55U2A7EN9X |
| NIST Chemistry Reference | 3(5)-methyl-5(3)-ethoxycarbonylpyrazole(4027-57-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| NFPA 704 |
|
Ethyl 3-methyl-1H-pyrazole-5-carboxylate price More Price(97)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 558354 | Ethyl 3-methylpyrazole-5-carboxylate 98% | 4027-57-0 | 5g | $64.8 | 2026-04-30 | Buy |
| TCI Chemical | E1100 | Ethyl 3-Methylpyrazole-5-carboxylate >98.0%(GC) | 4027-57-0 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | E1100 | Ethyl 3-Methylpyrazole-5-carboxylate >98.0%(GC) | 4027-57-0 | 5g | $78 | 2026-04-30 | Buy |
| Usbiological | 449124 | Ethyl 3-Methyl-5-pyrazolecarboxylate | 4027-57-0 | 5g | $403 | 2026-06-03 | Buy |
| Usbiological | 449124 | Ethyl 3-Methyl-5-pyrazolecarboxylate | 4027-57-0 | 25g | $785 | 2026-06-03 | Buy |
Ethyl 3-methyl-1H-pyrazole-5-carboxylate Chemical Properties,Uses,Production
Chemical Properties
White to yellow solid
Uses
Ethyl 3-Methyl-5-pyrazolecarboxylate is a useful synthetic intermediate. It is used to prepare tetrahydroisoquinoline amide substituted Ph pyrazoles as selective Bcl-2 inhibitors. It is also studies as a hypolipidemic agent.
Uses
Ethyl 3-methylpyrazole-5-carboxylate may be used to synthesize the following ligands:
- potassium salt of new dihydrobis(3-carboxyethyl-5-methylpyrazolyl)borate (BpCOOEt,Me)
- [(3-carboxy-5-methyl-1H-1-pyrazolyl) (3-methyl-5-carboxy-1H-1-pyrazolyl)methane, which readily forms Zn(II) and Cd(II) complexes
- bis(3-carboxy-5-methyl-1H-1-pyrazolyl)methane, which readily forms Zn(II) and Cd(II) complexes
General Description
Ethyl 3-methylpyrazole-5-carboxylate can be prepared by reacting ethyl acetylpyruvate and hydrazine.
Synthesis
615-79-2
4027-57-0
The general procedure for the synthesis of ethyl 3-methylpyrazole-5-carboxylate from ethyl acetylpyruvate was as follows: hydrazine monohydrate (5.4 mL, 110.68 mmol) was slowly added dropwise to a solution of EtOH/AcOH (100/1 mL) of ethyl 2,4-dioxovalerate (11.67 g, 73.79 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 15 h. The reaction mixture was poured into water (50 mL) and saturated aqueous NaHCO3 solution (5 mL) and extracted with EtOAc (3 x 50 mL). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford ethyl 5-methyl-1H-pyrazole-3-carboxylate (8.41 g, white solid, 74% yield), which could be used for the subsequent reaction without further purification. The product was characterized as follows: 1H NMR (CDCl3, 250 MHz): δ 6.55 (s, 1H), 4.34 (q, J = 7.13 Hz, 2H), 2.35 (s, 3H), 1.33 (t, J = 7.13 Hz, 3H); EI-MS: m/z = 155 [M+1]+.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 5, p. 2180 - 2194
[2] Patent: WO2009/7399, 2009, A1. Location in patent: Page/Page column 80
[3] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 39
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 15, p. 3017 - 3023
[5] Journal of the Chemical Society, 1945, p. 114
Ethyl 3-methyl-1H-pyrazole-5-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3991 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from Ethyl 3-methyl-1H-pyrazole-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | Ethyl 3-methyl-1H-pyrazole-5-carboxylate
4027-57-0
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | Ethyl 3-methyl-1H-pyrazole-5-carboxylate
4027-57-0
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Ethyl 3-methyl-1H-pyrazole-5-carboxylate
4027-57-0
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Ethyl 3-methyl-1H-pyrazole-5-carboxylate
4027-57-0
- $2.00
- 99%
- Career Henan Chemical Co
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