7-Hydroxy-4-(trifluoromethyl)coumarin
- CAS No.
- 575-03-1
- Chemical Name:
- 7-Hydroxy-4-(trifluoromethyl)coumarin
- Synonyms
- 7-HYDROXY-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;TFMU;BUTTPARK 20\02-70;TFMU, Coumarin 174;TIMTEC-BB SBB006559;Acenocoumarol Impurity 51;TRIFLUOROMETHYLUMBELLIFERONE;4-(TRIFLUOROMETHYL)UMBELLIFERON;4-(TRIFLUOROMETHYL)UMBELLIFERONE;BETA-TRIFLUOROMETHYLUMBELLIFERONE
- CBNumber:
- CB1102257
- Molecular Formula:
- C10H5F3O3
- Molecular Weight:
- 230.14
- MDL Number:
- MFCD00037578
- MOL File:
- 575-03-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 178-180 °C (lit.) |
|---|---|
| Boiling point | 311.4±42.0 °C(Predicted) |
| Density | 1.4435 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMF: soluble |
| pka | 7.23±0.20(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| λmax | 330nm(Toluene)(lit.) |
| BRN | 210932 |
| InChI | InChI=1S/C10H5F3O3/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4,14H |
| InChIKey | CCKWMCUOHJAVOL-UHFFFAOYSA-N |
| SMILES | C1(=O)OC2=CC(O)=CC=C2C(C(F)(F)F)=C1 |
| CAS DataBase Reference | 575-03-1(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-25 | |||||||||
| Safety Statements | 26-36-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29322090 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
7-Hydroxy-4-(trifluoromethyl)coumarin price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 368512 | 7-Hydroxy-4-(trifluoromethyl)coumarin 98% | 575-03-1 | 250mg | $53.7 | 2023-01-07 | Buy |
| Sigma-Aldrich | 368512 | 7-Hydroxy-4-(trifluoromethyl)coumarin 98% | 575-03-1 | 1g | $108 | 2023-01-07 | Buy |
| TCI Chemical | H1422 | 7-Hydroxy-4-(trifluoromethyl)coumarin >98.0%(HPLC)(T) | 575-03-1 | 1g | $57 | 2026-04-30 | Buy |
| TCI Chemical | H1422 | 7-Hydroxy-4-(trifluoromethyl)coumarin >98.0%(HPLC)(T) | 575-03-1 | 5g | $200 | 2026-04-30 | Buy |
| TRC | TRC-H971550-250MG | 7-Hydroxy-4-(trifluoromethyl)coumarin | 575-03-1 | 250mg | $78 | 2026-06-03 | Buy |
7-Hydroxy-4-(trifluoromethyl)coumarin Chemical Properties, Uses, Production
Description
7-Hydroxy-4-(trifluoromethyl)coumarin can be used as a reference standard for fluorescent pH indicator.
Chemical Properties
Off-white to light yellow or pink powder
Uses
Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.
Uses
7-Hydroxy-4-(trifluoromethyl)coumarin is an halogenated metabolite of Coumarin (C755380), an naturally occurring organic compound that exists in many plants. Coumarin is the precursor molecule in the synthesis of various synthetic anti-coagulant such as warfarin (W498500)/.
General Description
7-Hydroxy-4-(trifluoromethyl)coumarin is a class of 7-hydroxycoumarin that is majorly used as laser dyes. It has a characterized emission spectra and may be used in excited state proton transfer (ESPT).
Synthesis
372-31-6
108-46-3
575-03-1
GENERAL METHOD: Iodine (25 mol%) was added to a mixture of resorcinol (5 mmol) and ethyl 4,4,4-trifluoroacetoacetate (6 mmol) in toluene (1 mL). The reaction mixture was heated and stirred at 90 °C for 18 h. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (10 mL) and washed with distilled water (10 mL). The combined organic layers were dried with anhydrous sodium sulfate and the solvent was removed by evaporation under reduced pressure. The product was purified by fast column chromatography (silica gel, eluent: hexane/ethyl acetate = 95/5 to 80/20).
References
[1] Synthetic Communications, 2006, vol. 36, # 20, p. 2949 - 2956
[2] Monatshefte fur Chemie, 2013, vol. 144, # 3, p. 411 - 414
[3] Tetrahedron Letters, 2002, vol. 43, # 50, p. 9195 - 9197
[4] Synthetic Communications, 2004, vol. 34, # 21, p. 3997 - 4003
[5] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6715 - 6717
7-Hydroxy-4-(trifluoromethyl)coumarin Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai QiQiao Biological Technology Co., Ltd. | 021-37653318 15221675714 | 515366396@qq.com | China | 2087 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Scientia Pharmaceutical Technology Co., Ltd. | 21-21-54301573 13917723525 | sales@scientiapharm.com | China | 260 | 62 |
View Latest Price from 7-Hydroxy-4-(trifluoromethyl)coumarin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
575-03-1
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-08-12 | 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
575-03-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-10 | 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
575-03-1
|
$1.00 | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
575-03-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
575-03-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
575-03-1
- $1.00
- 99%
- Career Henan Chemical Co
575-03-1 (7-Hydroxy-4-(trifluoromethyl)coumarin) Related Search:
1of4
