5-IODO-1H-PYRIMIDIN-4-ONE
- CAS No.
- 4349-07-9
- Chemical Name:
- 5-IODO-1H-PYRIMIDIN-4-ONE
- Synonyms
- 4-Hydroxy-5-iodopyriMidine;108307;5-Iodopyrimidin-4-ol;5-Iodo-4-pyrimidinol;5-Iodopyrimidine-4-ol;5-iodo-1h-pyrimidin-6-one;5-Iodo-4(3H)-pyrimidinone;5-iodopyriMidin-4(1H)-one;5-IODO-1H-PYRIMIDIN-4-ONE;4(3H)-Pyrimidinone, 5-iodo-
- CBNumber:
- CB1103375
- Molecular Formula:
- C4H3IN2O
- Molecular Weight:
- 221.98
- MDL Number:
- MFCD02666079
- MOL File:
- 4349-07-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Iodopyrimidin-4-ol 95% | AS33490 | 1g | $64 |
| 5-Iodopyrimidin-4-ol 95% | AS33490 | 5g | $255 |
| 5-Iodopyrimidin-4-ol 95% | AS33490 | 25g | $808 |
| 5-Iodo-3,4-dihydropyrimidin-4-one 97% | AS158294 | 250mg | $174 |
| 5-Iodo-3,4-dihydropyrimidin-4-one 97% | AS158294 | 1g | $337 |
| More product size | |||
| Melting point | 254-265℃ |
|---|---|
| Density | 2.40±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 7.48±0.40(Predicted) |
| form | Solid |
| Appearance | Light yellow to brown Solid |
| Water Solubility | Soluble in water (67 g/L) (25°C). |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 4349-07-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
5-IODO-1H-PYRIMIDIN-4-ONE price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS33490 | 5-Iodopyrimidin-4-ol 95% | 1g | $64 | 2026-06-04 | Buy | |
| Activate Scientific | AS33490 | 5-Iodopyrimidin-4-ol 95% | 5g | $255 | 2026-06-04 | Buy | |
| Activate Scientific | AS33490 | 5-Iodopyrimidin-4-ol 95% | 25g | $808 | 2026-06-04 | Buy | |
| Activate Scientific | AS158294 | 5-Iodo-3,4-dihydropyrimidin-4-one 97% | 4349-07-9 | 250mg | $174 | 2026-06-04 | Buy |
| Activate Scientific | AS158294 | 5-Iodo-3,4-dihydropyrimidin-4-one 97% | 4349-07-9 | 1g | $337 | 2026-06-04 | Buy |
5-IODO-1H-PYRIMIDIN-4-ONE Chemical Properties,Uses,Production
Uses
4-Hydroxy-5-iodopyrimidine is an intermediate used in pharmaceuticals and chemical research.
Synthesis
51953-18-5
4349-07-9
General procedure for the synthesis of 4-hydroxy-5-iodopyrimidines from 4-hydroxypyrimidines: 10 g of 4(3H)-pyrimidinone was dissolved in 156 mL of acetic acid, and 25.8 g of N-iodosuccinimide was slowly added at 70 °C. The reaction system was then warmed up to 100 °C and the reaction was continuously stirred for 30 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature and then placed in an ice bath to promote crystallization of the product. Upon completion of crystallization, filtration was carried out under reduced pressure. The resulting solid was washed several times with deionized water and finally dried under reduced pressure to afford the target product 4-hydroxy-5-iodopyrimidine (16 g, yield: 67%). The product was characterized by 1H-NMR (300 MHz, DMSO-d6): δ 12.88 (broad peak, 1H), 8.42 (single peak, 1H), 8.17 (single peak, 1H).
References
[1] Synthesis (Germany), 2012, vol. 44, # 22, p. 3496 - 3504
[2] Patent: WO2011/99764, 2011, A2. Location in patent: Page/Page column 43
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 9, p. 2419 - 2422
[4] Patent: WO2005/16914, 2005, A1. Location in patent: Page/Page column 45
[5] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 7, p. 2719 - 2724
5-IODO-1H-PYRIMIDIN-4-ONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Compound Net Biotechnology Inc. | +8615303909093 | sales@compound-net.com | China | 2914 | 58 |
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