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alpha-Helical CRF (9-41)

alpha-Helical CRF (9-41) structure

CAS No.: 99658-03-4

Chemical Name:: alpha-Helical CRF (9-41)

Synonyms: alpha-Helical CRF (9-41);CORTICOTROPIN RELEASING FACTOR ANTAGONIST;α-Helical CRF (9-41) trifluoroacetate salt;ALPHA-HELICAL CORTICOTROPIN RELEASING FA CTOR;Alpha-Helical CRF (9-41) trifluoroacetate salt;α-Helical Corticotropin Releasing Factor (9-41);ALPHA-CORTICOTROPIN-RELEASING FACTOR 9-41, HELICAL;ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR (9-41);alpha-Helical corticotropin releasing factor fragment;α-helical corticotropin releasing factor fragment (9-41)

CBNumber:: CB1103870

Molecular Formula:: C22H25IN2O6

Molecular Weight:: 540.34817

MDL Number:: MFCD00081543

MOL File:: 99658-03-4.mol

Last updated:2026-09-12 18:48:34

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alpha-Helical CRF (9-41) Properties

storage temp.	−20°C
form	powder
color	white
UNSPSC Code	51111800
NACRES	NA.32

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

alpha-Helical CRF (9-41) price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C2917	Corticotropin Releasing Factor Antagonist ≥97% (HPLC)	99658-03-4	0.1mg	$171	2026-04-30	Buy
Biosynth	FH108583	Alpha-Helical CRF (9-41) trifluoroacetate salt	99658-03-4	500ug	$900	2026-06-04	Buy
Biosynth	FH108583	Alpha-Helical CRF (9-41) trifluoroacetate salt	99658-03-4	250ug	$900	2026-06-04	Buy
Biosynth	FH108583	Alpha-Helical CRF (9-41) trifluoroacetate salt	99658-03-4	100ug	$900	2026-06-04	Buy
Biosynth	FH108583	Alpha-Helical CRF (9-41) trifluoroacetate salt	99658-03-4	1000ug	$1440	2026-06-04	Buy

Product number	Packaging	Price	Buy
C2917	0.1mg	$171	Buy
FH108583	500ug	$900	Buy
FH108583	250ug	$900	Buy
FH108583	100ug	$900	Buy
FH108583	1000ug	$1440	Buy

alpha-Helical CRF (9-41) Chemical Properties, Uses, Production

Uses

α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo[1][2].

Biochem/physiol Actions

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

in vivo

α-Helical Corticotropin Releasing Factor (9-41) (10 μg; the third or lateral ventricle of the brain injection; once) significantly decreases plasma GH values^[1]. α-Helical Corticotropin Releasing Factor (9-41) (100 ng/kg; i.c.v. once) affects rhlL-1/β-induced enhancement of the splenic sympathetic activity^[2].

Animal Model:	Adult Sprague-Dawley rats^[1]
Dosage:	10 μg
Administration:	The third or lateral ventricle of the brain injection; 10 μg once
Result:	Abolished the 10 min electroshocks-produced the decreasing of plasma GH levels by injected into the third or lateral ventricle of the brain 45 min before exposure to stress.

Animal Model:	Adult Sprague-Dawley rats with immunity of endogenous somatostatin (SS)^[1]
Dosage:	10 μg
Administration:	Lateral ventricle brain injection; 10 μg once
Result:	Showed no effect on plasma GH values in rats whose endogenous SS had been immunoneutralized, but did interfere with the stimulatory effect of GH-releasing factor (GRF).

Animal Model:	Male Wistar rats with rhlL-1/β injection^[2]
Dosage:	100 ng/kg
Administration:	Intracerebroventricularly injection; 100 ng/kg once
Result:	Completely blocked the rhlL-1/β-induced enhancement of the splenic sympathetic activity, but failed to alter the enhancement of nociceptive behaviors caused by rhlL-1/β.

References

[1] Rivier C, Vale W. Involvement of corticotropin-releasing factor and somatostatin in stress-induced inhibition of growth hormone secretion in the rat. Endocrinology. 1985 Dec;117(6):2478-82. DOI:10.1210/endo-117-6-2478
[2] Takakazu Oka, et al. Intracerebroventricular injection of interleukin-1/β induces hyperalgesia in rats. Brain Research, 624 (1993) 61-68.

alpha-Helical CRF (9-41) Preparation Products And Raw materials

Raw materials

Preparation Products

alpha-Helical CRF (9-41) Suppliers

Global Suppliers ( 55)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7236	62
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303	Caroline@youngshechem.com	China	4725	58
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Sigma-Aldrich	80
Nanjing Leon Biological Technology Co., Ltd.	55
Nanjing Peptide Biotech Ltd.	55
Chengdu Youngshe Chemical Co., Ltd.	58
Hangzhou Peptidego Biotech Co.,Ltd.	58

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CORTICOTROPIN RELEASING FACTOR ANTAGONIST H-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2 ASP-LEU-THR-PHE-HIS-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-ALA-GLU-GLN-ALA-LEU-ASN-ARG-LEU-LEU-GLU-ALA-NH2 ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2 ALPHA-HELICAL CORTICOTROPIN RELEASING FA CTOR α-helical corticotropin releasing factor fragment (9-41) ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR (9-41) ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR FRAGMENT (9-41) ALPHA-CORTICOTROPIN-RELEASING FACTOR 9-41, HELICAL alpha-Helical corticotropin releasing factor fragment methyl (2S)-2-[[(3R)-3-hydroxy-4-(phenylmethoxycarbonylamino)butanoyl]amino]-3-(2-iodophenyl)propanoate L-α-Aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-α-glutamyl-L-methionyl-L-leucyl-L-α-glutamyl-L-methionyl-L-alanyl-L-lysyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-α-glutamyl-L-glutaminyl-L-alanyl-L-alanyl-L-leucyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alanine α-Helical CRF (9-41) trifluoroacetate salt alpha-Helical CRF (9-41) |alpha|a-Helical Corticotropin Releasing Factor (9-41) Alpha-Helical CRF (9-41) trifluoroacetate salt α-Helical Corticotropin Releasing Factor (9-41) alpha-Helical CRF (9-41) 99658-03-4 C166H273N45O54S2 C22H25IN2O6 CRF Other Peptides Peptides Releasing Factors Biochemicals and Reagents BioChemical Amino Acids and Peptides CRF receptor and related