a-Helical Corticotropin Releasing Factor (12-41)
- CAS No.
- 158535-55-8
- Chemical Name:
- a-Helical Corticotropin Releasing Factor (12-41)
- Synonyms
- a-Helical CRF (12-41);α-Helical CRF (12-41);PubChem ID: 131849100;α-Helical CRF (12-41);ALFA-HELICAL CRF (12-41);α-Helical CRF (12-41) trifluoroacetate salt;12-41-Corticotropin-releasing factor(human);Alpha-Helical CRF (12-41) trifluoroacetate salt;a-Helical Corticotropin Releasing Factor (12-41);PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2
- CBNumber:
- CB12476804
- Molecular Formula:
- C152H251N43O47S2
- Molecular Weight:
- 3497.01
- MDL Number:
- MFCD00214568
- MOL File:
- 158535-55-8.mol
- TDS File:
- TDS
a-Helical Corticotropin Releasing Factor (12-41) price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VAC-00387 | α-Helical CRF (12-41) | 1mg | $260.15 | 2026-06-05 | Buy | |
| Biosynth | VAC-00387 | α-Helical CRF (12-41) | 5mg | $780.45 | 2026-06-05 | Buy | |
| Biosynth | VAC-00387 | α-Helical CRF (12-41) | 10mg | $1300.8 | 2026-06-05 | Buy | |
| Biosynth | FH108949 | Alpha-Helical CRF (12-41) trifluoroacetate salt | 158535-55-8 | 1000ug | $900 | 2026-06-04 | Buy |
| Biosynth | FH108949 | Alpha-Helical CRF (12-41) trifluoroacetate salt | 158535-55-8 | 500ug | $900 | 2026-06-04 | Buy |
a-Helical Corticotropin Releasing Factor (12-41) Chemical Properties, Uses, Production
Uses
a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].
in vivo
a-Helical Corticotropin Releasing Factor (12-41) (15-150 μg; s.c.; isolated for 30 or 60 min) suppresses the active behavioral response characteristic of guinea pig pups to brief isolation in novel surroundings[1].
| Animal Model: | Guinea pig pups (20-26 days old and )[1] |
| Dosage: | 15, 50, 150 μg per animal |
| Administration: | Subcutaneous injection; isolated in novel surroundings for 30 min or 60 min. |
| Result: | Resulted pups vocalized more and exhibited more locomotor activity in 20- to 26-day-old pups. Increased levels of vocalizing in isolated 4- to 6-day-old pups at 50 μg dose, though no changes were seen in locomotor activity. |
References
[1] Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47. DOI:10.1002/(sici)1098-2302(199707)31:1<39::aid-dev4>3.0.co;2-v
[2] Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93.
a-Helical Corticotropin Releasing Factor (12-41) Preparation Products And Raw materials
Raw materials
Preparation Products
a-Helical Corticotropin Releasing Factor (12-41) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
