PD407824
- CAS No.
- 622864-54-4
- Chemical Name:
- PD407824
- Synonyms
- PD407824;PD 0407824;PD-407824, ≥98% (HPLC);9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 9-hydroxy-4-phenyl-
- CBNumber:
- CB11075013
- Molecular Formula:
- C20H12N2O3
- Molecular Weight:
- 328.32
- MDL Number:
- MFCD09753286
- MOL File:
- 622864-54-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.507±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| pka | 9.02±0.20(Predicted) |
| form | powder |
| color | yellow to orange |
| InChI | 1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25) |
| InChIKey | IAUZTOZLTFSMIE-UHFFFAOYSA-N |
| SMILES | Oc1ccc2[nH]c3cc(-c4ccccc4)c5C(=O)NC(=O)c5c3c2c1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
PD407824 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0111 | PD-407824 ≥98% (HPLC) | 622864-54-4 | 25mg | $635 | 2026-04-30 | Buy |
| Sigma-Aldrich | PZ0111 | PD-407824 ≥98% (HPLC) | 622864-54-4 | 5mg | $147 | 2024-03-01 | Buy |
| Cayman Chemical | 25989 | PD 407824 ≥98% | 622864-54-4 | 1mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 25989 | PD 407824 ≥98% | 622864-54-4 | 5mg | $182 | 2026-04-30 | Buy |
| Cayman Chemical | 25989 | PD 407824 ≥98% | 622864-54-4 | 10mg | $303 | 2026-04-30 | Buy |
PD407824 Chemical Properties, Uses, Production
Description
PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively). It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 μM), Cdk4 (IC50 = 3.75 μM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 μM for all), and other Cdks (IC50s = >50 μM). PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 μM. It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts. PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.
Uses
PD-407824 is a Wee1/Chk1 inhibitor useful as cancer treatments.
Uses
PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.
Biological Activity
Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC 50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC 50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μ M for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.
Biochem/physiol Actions
PD-407824 is a Wee1/Chk1 inhibitor.
storage
Store at +4°C
References
[1] JEFF B. SMAILL . Synthesis and structure–activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases[J]. European Journal of Medicinal Chemistry, 2008, 43 6: Pages 1276-1296. DOI: 10.1016/j.ejmech.2007.07.016
[2] BRIAN D. PALMER. 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. StructureActivity Relationships for Chromophore Modification and Phenyl Ring Substitution[J]. Journal of Medicinal Chemistry, 2006, 49 16: 4896-4911. DOI: 10.1021/jm0512591
[3] SHILPI ARORA . RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells[J]. Gynecologic oncology, 2010, 118 3: Pages 220-227. DOI: 10.1016/j.ygyno.2010.05.006
[4] LINGLING FENG. Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation.[J]. Cell reports, 2016, 15 9: 2063-2075. DOI: 10.1016/j.celrep.2016.04.066
PD407824 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
