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CDK1/2InhibitorIII

CDK1/2InhibitorIII Structure
CDK1/2InhibitorIII structure
CAS No.
443798-55-8
Chemical Name:
CDK1/2InhibitorIII
Synonyms
2 Inhibitor III;CDK1/2InhibitorIII;Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III;5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide;1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-
CBNumber:
CB11113964
Molecular Formula:
C15H13F2N7O2S2
Molecular Weight:
425.44
MDL Number:
MOL File:
443798-55-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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CDK1/2InhibitorIII Properties

Boiling point 649.1±65.0 °C(Predicted)
Density 1.72±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO: 10mg/mL
THF: soluble
acetone: soluble
form White solid
pka 6.61±0.70(Predicted)
color white
InChI 1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
InChIKey ARIOBGGRZJITQX-UHFFFAOYSA-N
SMILES Fc1c(c(ccc1)F)NC(=S)[n]2nc(nc2N)Nc3ccc(cc3)[S](=O)(=O)N
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 1
Storage Class 11 - Combustible Solids

CDK1/2InhibitorIII price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 217714 Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem 443798-55-8 1MG $159 2026-04-30 Buy
Cayman Chemical 18859 Cdk1/2 Inhibitor III ≥95% 443798-55-8 1mg $79 2021-12-16 Buy
Cayman Chemical 18859 Cdk1/2 Inhibitor III ≥95% 443798-55-8 5mg $315 2021-12-16 Buy
Biosynth FC175578 Cdk1/2 Inhibitor III 443798-55-8 1mg $393.54 2026-06-04 Buy
ChemScene CS-0046089 Cdk1/2 Inhibitor III 99.69% 443798-55-8 1mg $162 2026-06-04 Buy
Product number Packaging Price Buy
217714 1MG $159 Buy
18859 1mg $79 Buy
18859 5mg $315 Buy
FC175578 1mg $393.54 Buy
CS-0046089 1mg $162 Buy

CDK1/2InhibitorIII Chemical Properties, Uses, Production

Uses

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/2 Inhibitor III is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50s = 0.6 and 0.5 nM, respectively). It less potently inhibits CDC2-like kinases 1 and 3, VEGFR2, and GSK-3β (IC50s = 8.9, 29, 32, and 140 nM, respectively) and is without effect against a panel of other kinases. Cdk1/2 Inhibitor III blocks the growth of several cancer cell lines (IC50 values range from 20 to 92 nM).

Uses

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. CDK 1/2 inhibitor III selectively inhibits CDK1 and CDK2. Studies have shown that CDK 1/2 Inhibitor III can also inhibit in vitro cellular proliferation in various human tumor cells.

General Description

A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 μM).

Biochem/physiol Actions

Cell permeable: yes

IC 50

Cdk1/cyclin B: 2.1 μM (IC50)

CDK1/2InhibitorIII Preparation Products And Raw materials

Raw materials

Preparation Products

CDK1/2InhibitorIII Suppliers

Global Suppliers ( 25)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10233 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Aladdin Scientific tp@aladdinsci.com United States 50068 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Energy Chemical 58
cjbscvictory 58
TargetMol Chemicals Inc. 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
Shanghai Amole Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58

View Latest Price from CDK1/2InhibitorIII manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cdk1/2 Inhibitor III pictures 2026-07-27 Cdk1/2 Inhibitor III
443798-55-8
 $123.00-795.00 99.94% 10g TargetMol Chemicals Inc.
Cdk1/2 Inhibitor III pictures 2026-07-27 Cdk1/2 Inhibitor III
443798-55-8
 $123.00-795.00 99.94% 10g TargetMol Chemicals Inc.

CDK1/2InhibitorIII Spectrum

CDK1/2InhibitorIII(443798-55-8)1HNMR

443798-55-8 (CDK1/2InhibitorIII) Related Search:

N-(5-(difluoromethoxy)-1H-pyrazol-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazolo[3,4-b]pyrazin-6-amine CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) THZ1 OTS964 hydrochloride
GSK-3326595

1of2

CDK1/2InhibitorIII 5-amino-N-(2,6-difluorophenyl)-3-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide 2 Inhibitor III Cdk-1/2 Inhibitor III,Cdk1/2 Inhibitor III 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)- 443798-55-8 C15H13F2N7O2S2