NORFLUOXETINE HYDROCHLORIDE
- CAS No.
- 57226-68-3
- Chemical Name:
- NORFLUOXETINE HYDROCHLORIDE
- Synonyms
- NORFLUOXETINE HCL;Fluoxetine EP Impurity H;NORFLUOXETINE HYDROCHLORIDE;Fluoxetine Impurity 8(EP-H);Norfluoxetine Hydrochloride (Standard);Norfluoxetine hydrochloride in methanol;Norfluoxetine Hydrochloride Solution, 100ppm;Fluoxetine Impurity 8(Fluoxetine EP Impurity H);Norfluoxetine hydrochloride (Desmethylfluoxetine);Norfluoxetine.HCl, 1mg/ml in Methanol (as free base)
- CBNumber:
- CB1112230
- Molecular Formula:
- C16H17ClF3NO
- Molecular Weight:
- 331.76
- MDL Number:
- MFCD01321043
- MOL File:
- 57226-68-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Norfluoxetine (hydrochloride) ≥98% | 15900 | 1mg | $50 |
| Norfluoxetine (hydrochloride) ≥98% | 15900 | 5mg | $218 |
| Norfluoxetine (hydrochloride) ≥98% | 15900 | 10mg | $305 |
| Norfluoxetine (hydrochloride) | 15900 | 1mg | $45 |
| Norfluoxetine (hydrochloride) | 15900 | 10mg | $277 |
| More product size | |||
| storage temp. | -20°C |
|---|---|
| solubility | H2O: >4 mg/mL |
| form | solid |
| color | yellow |
| Water Solubility |
H2O: >4mg/mL DMSO: >5mg/mL |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | 1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H |
| InChIKey | GMTWWEPBGGXBTO-UHFFFAOYSA-N |
| SMILES | Cl[H].NCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
NORFLUOXETINE HYDROCHLORIDE price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) ≥98% | 57226-68-3 | 1mg | $50 | 2026-04-30 | Buy |
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) ≥98% | 57226-68-3 | 5mg | $218 | 2026-04-30 | Buy |
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) ≥98% | 57226-68-3 | 10mg | $305 | 2026-04-30 | Buy |
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) | 57226-68-3 | 1mg | $45 | 2024-03-01 | Buy |
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) | 57226-68-3 | 10mg | $277 | 2024-03-01 | Buy |
NORFLUOXETINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.
Chemical Properties
NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid
Uses
Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant.
Uses
Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.
Biochem/physiol Actions
Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.
in vivo
Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1].
IC 50
5-HT Receptor; CaV3.3: 5 μM (IC50)
References
[1] CHRISTIAAN C VEERMAN. Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome.[J]. Circulation. Arrhythmia and electrophysiology, 2013, 6 5: 1002-1009. DOI:10.1161/circep.113.000239
[2] JUSTIN D LUTZ. Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems.[J]. Drug Metabolism and Disposition, 2013, 41 12: 2056-2065. DOI:10.1124/dmd.113.052639
[3] DAVID T. WONG PH.D. Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain[J]. Neuropsychopharmacology, 1993, 8 4: 337-344. DOI:10.1038/npp.1993.33
[4] JUN ZUO. Fluoxetine is a potent inhibitor of coxsackievirus replication.[J]. Antimicrobial Agents and Chemotherapy, 2012, 56 9: 4838-4844. DOI:10.1128/aac.00983-12
[5] CONOR MCCLENAGHAN. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.[J]. Journal of General Physiology, 2016, 147 6: 497-505. DOI:10.1085/jgp.201611601
NORFLUOXETINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| Sinco Pharmachem (ShenZhen) R&D Co., Ltd. | +undefined18603013401 | jack.lin@sincopharmachem.com | China | 10000 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
View Lastest Price from NORFLUOXETINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Norfluoxetine Hydrochloride
57226-68-3
|
$40.00-198.00 | 99.75% | 10g | TargetMol Chemicals Inc. |
-
- Norfluoxetine Hydrochloride
57226-68-3
- $40.00-198.00
- 99.75%
- TargetMol Chemicals Inc.
57226-68-3(NORFLUOXETINE HYDROCHLORIDE)Related Search:
1of4
