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| | NORFLUOXETINE HYDROCHLORIDE Basic information |
| Product Name: | NORFLUOXETINE HYDROCHLORIDE | | Synonyms: | NORFLUOXETINE HCL;NORFLUOXETINE HYDROCHLORIDE;(+/-)-GAMMA-[4-(TRIFLUOROMETHYL)PHENOXY]-BENZENEPROPANAMINE HYDROCHLORIDE;3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE;3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE;Benzenepropanamine, gamma-(4-(trifluoromethyl)phenoxy)-, hydrochloride;1-(3-Amino-1-phenylpropoxy)-4-(trifluoromethyl)benzene hydrochloride;Norfluoxetine Hydrochloride Solution, 100ppm | | CAS: | 57226-68-3 | | MF: | C16H17ClF3NO | | MW: | 331.76 | | EINECS: | | | Product Categories: | | | Mol File: | 57226-68-3.mol |  |
| | NORFLUOXETINE HYDROCHLORIDE Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: >4 mg/mL | | form | solid | | color | yellow | | Water Solubility | H2O: >4mg/mL
DMSO: >5mg/mL | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | | InChI | 1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H | | InChIKey | GMTWWEPBGGXBTO-UHFFFAOYSA-N | | SMILES | Cl[H].NCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | NORFLUOXETINE HYDROCHLORIDE Usage And Synthesis |
| Description | Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent. | | Chemical Properties | NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid | | Uses | Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant. | | Uses | Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons. | | Biochem/physiol Actions | Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit. | | in vivo | Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1]. | | IC 50 | 5-HT Receptor; CaV3.3: 5 μM (IC50) | | References | [1] CHRISTIAAN C VEERMAN. Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome.[J]. Circulation. Arrhythmia and electrophysiology, 2013, 6 5: 1002-1009. DOI:10.1161/circep.113.000239
[2] JUSTIN D LUTZ. Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems.[J]. Drug Metabolism and Disposition, 2013, 41 12: 2056-2065. DOI:10.1124/dmd.113.052639
[3] DAVID T. WONG PH.D. Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain[J]. Neuropsychopharmacology, 1993, 8 4: 337-344. DOI:10.1038/npp.1993.33
[4] JUN ZUO. Fluoxetine is a potent inhibitor of coxsackievirus replication.[J]. Antimicrobial Agents and Chemotherapy, 2012, 56 9: 4838-4844. DOI:10.1128/aac.00983-12
[5] CONOR MCCLENAGHAN. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.[J]. Journal of General Physiology, 2016, 147 6: 497-505. DOI:10.1085/jgp.201611601 |
| | NORFLUOXETINE HYDROCHLORIDE Preparation Products And Raw materials |
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