1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid
![1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid Structure](CAS/GIF/898746-35-5.gif)
- CAS No.
- 898746-35-5
- Chemical Name:
- 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid
- Synonyms
- 7-Azaindole-6-carboxylic ...;7-AZAINDOLE-6-CARBOXYLIC ACID;1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid
- CBNumber:
- CB1117831
- Molecular Formula:
- C8H6N2O2
- Molecular Weight:
- 162.15
- MDL Number:
- MFCD08272223
- MOL File:
- 898746-35-5.mol
- MSDS File:
- SDS
| Density | 1.506±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| pka | 1.44±0.30(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C8H6N2O2/c11-8(12)6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H,9,10)(H,11,12) |
| InChIKey | LDJMQIKMKHNGDB-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=CC=C(C(O)=O)N=2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR927275 | 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid 95% | 898746-35-5 | 100mg | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR927275 | 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid 95% | 898746-35-5 | 250mg | $48 | 2026-06-04 | Buy |
| Apolloscientific | OR927275 | 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid 95% | 898746-35-5 | 1g | $94 | 2026-06-04 | Buy |
| Apolloscientific | OR927275 | 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid 95% | 898746-35-5 | 5g | $453 | 2026-06-04 | Buy |
| Matrix Scientific | 309856 | 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid | 898746-35-5 | 250.00mg | $58 | 2026-05-19 | Buy |
1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid Chemical Properties, Uses, Production
Synthesis
![1H-pyrrolo[2,3-b]pyridine-6-carbonitrile](/CAS/GIF/189882-33-5.gif)
189882-33-5
![1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID](/CAS/GIF/898746-35-5.gif)
898746-35-5
General procedure for the synthesis of 7-azaindole-6-carboxylic acid from 6-cyano-7-azaindole: 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile (120 mg, 0.84 mmol) was dissolved in ethanol (10 mL). To the solution was added 6 N sodium hydroxide solution (1.4 mL, 8.4 mmol) and the reaction mixture was stirred at 90 °C for 18 hours. Upon completion of the reaction, the mixture was distilled under reduced pressure to remove the solvent. Subsequently, a 1 N hydrochloric acid solution was added to the residue for acidification. The acidified solution was extracted with ethyl acetate. The organic phases were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by column chromatography to afford the target product 7-azaindole-6-carboxylic acid (100 mg, 74% yield). The nuclear magnetic resonance hydrogen spectrum (1H-NMR, 400 MHz, DMSO-d6) data were as follows: δ 12.08 (broad single peak, 1H), 8.11 (double peak, 1H), 7.83 (double peak, 1H), 7.70 (double peak, 1H), 6.58 (double peak, 1H).
References
[1] Patent: WO2014/73904, 2014, A1. Location in patent: Paragraph 942-945
[2] Patent: WO2012/95463, 2012, A1. Location in patent: Page/Page column 80
[3] Patent: CN104387385, 2016, B. Location in patent: Paragraph 0040-0045
1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing SynTitan Pharmaceutical Co., Ltd. | 025-57027686 17372956142 | li_lan@syntitan.com | China | 9999 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3829 | 58 |
| Dtchem Laboratories,（Gan Su）Co.,Ltd. | 18993961550 18993966060 | sales@techbiochem.com | China | 773 | 61 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3982 | 55 |
View Latest Price from 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID pictures](https://img.chemicalbook.com/ProductImageEN/2018-8/Small/90bf5659-27a3-42bf-adab-72c68d10d33c.png) |
2019-07-06 | 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID
898746-35-5
|
$500.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID
898746-35-5
- $500.00
- 98%
- Career Henan Chemical Co
