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ChemicalBook >> CAS DataBase List >>6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Structure
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- structure
CAS No.
2421153-77-5
Chemical Name:
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-
Synonyms
ET-JQ1-OH;(+)-JQ1 bump, acid functionalized;(R)-2-((S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL)BUTANOIC ACID;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-;(2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoic acid
CBNumber:
CB112073510
Molecular Formula:
C21H21ClN4O2S
Molecular Weight:
428.94
MDL Number:
MOL File:
2421153-77-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:06:35
Request For Quotation

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Properties

Boiling point 663.8±65.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
solubility Soluble to 100 mM in DMSO
pka 4.11±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362-P301+P312+P330

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA02CRAV (R)-2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoic acid 95% 2421153-77-5 10mg $320 2026-06-02 Buy
DC Chemicals DC71321 ET-JQ1-OH >98% 2421153-77-5 25mg $600 2026-05-24 Buy
DC Chemicals DC71321 ET-JQ1-OH 98% 2421153-77-5 50mg $900 2026-05-24 Buy
DC Chemicals DC71321 ET-JQ1-OH >98% 2421153-77-5 100mg $1350 2026-05-24 Buy
Product number Packaging Price Buy
AA02CRAV 10mg $320 Buy
DC71321 25mg $600 Buy
DC71321 50mg $900 Buy
DC71321 100mg $1350 Buy

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Chemical Properties, Uses, Production

Uses

ET-JQ1-OH is an allele-specific BET inhibitor[1].

Biological Activity

(+)-JQ1 bump, acid functionalized is a BET bromodomain binding analog of (+)-JQ1 that selectively binds single point mutant form of Brd4 (Brd4BD2 L387A). Functionalized with a carboxylic acid group to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with compound binding ability.

storage

Store at -20°C

References

[1] Bond AG, et al. Stereoselective synthesis of allele-specific BET inhibitors. Org Biomol Chem. 2020 Oct 7;18(38):7533-7539. DOI:10.1039/d0ob01165g

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Preparation Products And Raw materials

Raw materials

Preparation Products

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
SuZhou GoodChemTech Co., Ltd 18136139868; 18136139868 jinlun@goodchemtech.cn China 321 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 19370895928 qqyang@aikonchem.com China 9995 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Hangzhou J&H Chemical Co., Ltd. 59
Jilin Province Woda Biotechnology Co., Ltd. 58
SuZhou GoodChemTech Co., Ltd 58
TargetMol Chemicals Inc. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ET-JQ1-OH pictures 2026-04-21 ET-JQ1-OH
2421153-77-5
 $2140.00-3520.00 10g TargetMol Chemicals Inc.
  • ET-JQ1-OH pictures
  • ET-JQ1-OH
    2421153-77-5
  • $2140.00-3520.00
  • TargetMol Chemicals Inc.

2421153-77-5 (6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)-) Related Search:

AU-15330 ARV-825 NSC228155 ARV-771 dBET1
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6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-α-ethyl-2,3,9-trimethyl-, (αR,6S)- ET-JQ1-OH (2R)-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,?]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoic acid (+)-JQ1 bump, acid functionalized (R)-2-((S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPIN-6-YL)BUTANOIC ACID 2421153-77-5