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Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]-

Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- structure

CAS No.: 2319587-80-7

Chemical Name:: Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]-

Synonyms: Anticancer agent 82;Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]-

CBNumber:: CB112169705

Molecular Formula:: C19H18Cl2N4O

Molecular Weight:: 389.28

MDL Number:

MOL File:: 2319587-80-7.mol

MSDS File:: SDS

Last updated:2026-05-11 16:31:51

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Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Properties

Boiling point	606.3±65.0 °C(Predicted)
Density	1.363±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	5.56±0.10(Predicted)
color	Light yellow to orange

Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0611676	Vimentin-IN-1 99.74%	2319587-80-7	5mg	$217	2026-06-04	Buy
ChemScene	CS-0611676	Vimentin-IN-1 99.74%	2319587-80-7	10mg	$379	2026-06-04	Buy
ChemScene	CS-0611676	Vimentin-IN-1 99.74%	2319587-80-7	25mg	$758	2026-06-04	Buy
ChemScene	CS-0611676	Vimentin-IN-1 99.74%	2319587-80-7	50mg	$1192	2026-06-04	Buy
ChemScene	CS-0611676	Vimentin-IN-1 99.74%	2319587-80-7	100mg	$1787	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0611676	5mg	$217	Buy
CS-0611676	10mg	$379	Buy
CS-0611676	25mg	$758	Buy
CS-0611676	50mg	$1192	Buy
CS-0611676	100mg	$1787	Buy

Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Chemical Properties, Uses, Production

Uses

Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type IIIintermediate filament proteinvimentin(VIM), to induce hyperphosphorylationof Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability andpharmacokineticprofiles than FiVe1[1].

in vivo

Vimentin-IN-1 (compound 4e) (10 mg/kg; p.o.; single dose) shows better oral pharmacokinetic properties than Five1^[1].
Pharmacokinetic properties of Vimentin-IN-1 in mice^[1]

	Route	Dose (mg/kg)	AUC_0-last (ng·h/mL)	AUC_0-inf (ng·h/mL)	T_1/2 (h)	T_max (h)	T_last (h)	C_max (ng/mL)
4e	PO	10	371.33	534.33	4.68	0.67	8	154.67
4e	IP	1	208.33	211.33	0.59	0.25	4	197.00
Five1	PO	25	309.78	339.21	4.57	0.5	18	110.43

References

[1] Martínez-Pea F, et al. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15;242:114638. DOI:10.1016/j.ejmech.2022.114638

Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Suppliers

Global Suppliers ( 4)

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Younan Technology Co., Ltd	020-82000279 18988941452	YN_research@163.com	China	2984	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58

Supplier	Advantage
Guangzhou Younan Technology Co., Ltd	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Latest Price from Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	Anticancer agent 82 2319587-80-7	$1360.00			10g	TargetMol Chemicals Inc.

Anticancer agent 82
2319587-80-7
$1360.00
TargetMol Chemicals Inc.

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Cinnoline, 8-chloro-4-[4-(3-chloro-5-methoxyphenyl)-1-piperazinyl]- Anticancer agent 82 2319587-80-7