ChemicalBook >> CAS DataBase List >>4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one structure

CAS No.: 2649530-57-2

Chemical Name:: 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one

Synonyms: 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one

CBNumber:: CB112195872

Molecular Formula:: C37H37D5F2N8O4

Molecular Weight:: 705.81

MDL Number:

MOL File:: 2649530-57-2.mol

MSDS File:: SDS

Last updated:2025-07-27 11:21:18

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4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one Properties

Boiling point	850.659±75.00 °C(Press: 760.00 Torr)(predicted)
Density	1.369±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility	Acetonitrile: soluble
form	A solid

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22376	Posaconazole-d5 ≥98%deuteratedforms(d₁-d₅)	2649530-57-2	500μg	$480	2026-04-30	Buy
Cayman Chemical	22376	Posaconazole-d5 ≥98%deuteratedforms(d₁-d₅)	2649530-57-2	1mg	$864	2026-04-30	Buy
Cayman Chemical	22376	Posaconazole-d5 ≥98% deuterated forms (d₁-d₅)	2649530-57-2	500 μg	$436	2024-03-01	Buy
Cayman Chemical	22376	Posaconazole-d5 ≥98% deuterated forms (d₁-d₅)	2649530-57-2	1 mg	$785	2024-03-01	Buy
aablocks	AA01EPO5	Posaconazole-d5 ≥98%deuteratedforms(d1-d5)	2649530-57-2	1mg	$864	2026-05-30	Buy

Product number	Packaging	Price	Buy
22376	500μg	$480	Buy
22376	1mg	$864	Buy
22376	500 μg	$436	Buy
22376	1 mg	$785	Buy
AA01EPO5	1mg	$864	Buy

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one Chemical Properties, Uses, Production

Description

Posaconazole-d₅ is intended for use as an internal standard for the quantification of posaconazole by GC- or LC-MS. Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes.¹ Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC₅₀s = 7-200 nM), which results in a disruption in the synthesis of ergosterol , a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.²

References

1. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole J. Antimicrob. Chemother. 56(Suppl 1),i39-i48(2005).
2. Munayyer, H.K., Mann, P.A., Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds Antimicrob. Agents Chemother. 48(10),3690-3696(2004).

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one Suppliers

Global Suppliers ( 6)

Supplier	Tel	Email	Country	ProdList	Advantage
LGC Science (Shanghai) Ltd.	17717235263	offer.de@lgcgroup.com	China	19036	58
CHINA ISOTOPE CO., LIMITED	02151600108 13062666369	info@isotopechem.com	China	4721	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58

Supplier	Advantage
LGC Science (Shanghai) Ltd.	58
CHINA ISOTOPE CO., LIMITED	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

2649530-57-2 (4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one) Related Search:

Efinaconazole-d4 CLOTRIMAZOLE-D5 Itraconazole-D5 Posaconazole-D-Glucuronide Posaconazole