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Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- structure

CAS No.: 2248703-42-4

Chemical Name:: Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-

Synonyms: SACLAC;CAS:2248703-42-4;2-Chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide;Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-

CBNumber:: CB112280479

Molecular Formula:: C20H40ClNO3

Molecular Weight:: 377.99

MDL Number:

MOL File:: 2248703-42-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:05:11

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Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Properties

Boiling point	560.1±50.0 °C(Predicted)
Density	1.016±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Chloroform: soluble
form	A solid
pka	13.01±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H302-H314
Precautionary statements	P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	9003926	SACLAC ≥95%	2248703-42-4	1mg	$70	2026-04-30	Buy
Cayman Chemical	9003926	SACLAC ≥95%	2248703-42-4	5mg	$222	2026-04-30	Buy
Cayman Chemical	9003926	SACLAC ≥95%	2248703-42-4	10mg	$376	2026-04-30	Buy
ChemScene	CS-1097884	SACLAC 99.70%	2248703-42-4	5mg	$238	2026-06-04	Buy
ChemScene	CS-1097884	SACLAC 99.70%	2248703-42-4	10mg	$379	2026-06-04	Buy

Product number	Packaging	Price	Buy
9003926	1mg	$70	Buy
9003926	5mg	$222	Buy
9003926	10mg	$376	Buy
CS-1097884	5mg	$238	Buy
CS-1097884	10mg	$379	Buy

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Chemical Properties, Uses, Production

Uses

SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models[1][2].

Biological Activity

SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC .1 It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 μM.2 SACLAC (10 and 20 μM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg.

References

1.Ordóez, Y.F., Abad, J.L., Aseeri, M., et al.Activity-based imaging of acid ceramidase in living cellsJ. Am. Chem. Soc.141(19)7736-7742(2019) 2.Pearson, J.M., Tan, S.-F., Sharma, A., et al.Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemiaMol. Cancer Res.18(3)352-363(2020)

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Suppliers

Global Suppliers ( 21)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Zhengzhou Convergence Chemical Co. LTD	13393710386	3941078109@qq.com	China	9860	58
Hubei Kele Fine Chemical Co., Ltd	027-59101668 19945030958	2223443625@qq.com	China	7998	58
Hubei wei shi reagent group ltd., company	027-59102966 18717199209	2853877583@qq.com	China	2896	58
Wuhan Augda Biotechnology Co., Ltd	15071299552	262933239@qq.com	China	7201	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Aikon International Limited	17714375163	hywu@aikonchem.com	China	9974	58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	18171815831	1341138380@qq.com	China	4573	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5985	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Zhengzhou Convergence Chemical Co. LTD	58
Hubei Kele Fine Chemical Co., Ltd	58
Hubei wei shi reagent group ltd., company	58
Wuhan Augda Biotechnology Co., Ltd	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Aikon International Limited	58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58

View Latest Price from Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	SACLAC 2248703-42-4	$74.00-289.00		97.03%	10g	TargetMol Chemicals Inc.

SACLAC
2248703-42-4
$74.00-289.00
97.03%
TargetMol Chemicals Inc.

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Spectrum

Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-(2248703-42-4)¹HNMR

2248703-42-4 (Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-) Related Search:

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Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- SACLAC 2-Chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide CAS:2248703-42-4 2248703-42-4