SEX HORMONE BINDING GLOBULIN
- CAS No.
- Chemical Name:
- SEX HORMONE BINDING GLOBULIN
- Synonyms
- SHBG;TEBG;HSHBG;HTEBG;SHBG, HUMAN;SEX HORMONE BINDING GLOBULIN;SEX HORMONE BINDING GLOBULIN, HUMAN;TESTOSTERONE-ESTRADIOL BINDING GLOBULIN;Recombinant Human SHBG Protein, His Tag;TESTOSTERONE-ESTRADIOL BINDING GLOBULIN, HUMAN
- CBNumber:
- CB1125683
- Molecular Formula:
- Molecular Weight:
- 612.74
- MDL Number:
- MFCD00163748
- MOL File:
- Mol file
| storage temp. | −20°C |
|---|---|
| form | buffered aqueous glycerol solution |
| biological source | rabbit |
| FDA UNII | YJ0ZSQ5NF5 |
| UNSPSC Code | 12352203 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Hazard Codes | B |
|---|---|
| WGK Germany | 1 |
| Storage Class | 12 - Non Combustible Liquids |
SEX HORMONE BINDING GLOBULIN price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S1437 | Sex Hormone-Binding Globulin from human serum ≥95% (SDS-PAGE), buffered aqueous glycerol solution | 10μG | $767 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SAB1304899 | ANTI-SHBG (N-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 400μl | $461 | 2023-01-07 | Buy | |
| Usbiological | 553895 | Sex Hormone Binding Globulin PurifiedbyProteinAaffinitychromatographyfromtissueculturesupernatant. | 1mg | $1120 | 2026-06-03 | Buy | |
| Usbiological | 553894 | Sex Hormone Binding Globulin PurifiedbyProteinGaffinitychromatographyfromtissueculturesupernatant. | 1mg | $1120 | 2026-06-03 | Buy | |
| Usbiological | 549916 | Sex Hormone Binding Globulin PurifiedbyProteinA/Gaffinitychromatography. | 200ul | $545 | 2026-06-03 | Buy |
SEX HORMONE BINDING GLOBULIN Chemical Properties, Uses, Production
Uses
Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.
General Description
Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.
Biochem/physiol Actions
Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.
Description
SHBG Human Recombinant produced in CHO cells is a single, glycosylated, polypeptide chain containing a total of 428 amino acids, having a molecular mass of 46.79kDa (calculated), the SHBG is fused to a 6 a.a C-terminal His tag and also includes a myc-epitope.
The Human SHBG is purified by proprietary chromatographic techniques.
Source
CHO cells
Background
Sex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen/estrogen balance, thyroid hormones, and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus.
SEX HORMONE BINDING GLOBULIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 9926 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| Shanghai Xinyu Biotechnology Co., Ltd | 13301728348 | 13301728348@163.com | China | 8000 | 58 |
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