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2-Amino-4-fluorobenzonitrile

2-Amino-4-fluorobenzonitrile Structure
2-Amino-4-fluorobenzonitrile structure
CAS No.
80517-22-2
Chemical Name:
2-Amino-4-fluorobenzonitrile
Synonyms
4-Fluoroanthranilonitrile;Amino-4-fluorobenzonitrile;2-Amino-4-fluorobenzonitrile;Benzonitrile, 2-amino-4-fluoro-;4-Fluoroanthranilonitrile, 2-Cyano-5-fluoroaniline
CBNumber:
CB11263751
Molecular Formula:
C7H5FN2
Molecular Weight:
136.13
MDL Number:
MFCD09955451
MOL File:
80517-22-2.mol
Last updated:2026-09-12 18:48:36
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2-Amino-4-fluorobenzonitrile Properties

Melting point 102.2 °C (decomp)
Boiling point 284.7±25.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form crystals
pka 0.80±0.10(Predicted)
color Light purple

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P305+P351+P338
HazardClass  TOXIC
HS Code  2926907090

2-Amino-4-fluorobenzonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FA67713 2-Amino-4-fluorobenzonitrile 80517-22-2 25g $150 2026-06-04 Buy
Biosynth FA67713 2-Amino-4-fluorobenzonitrile 80517-22-2 50g $227.5 2026-06-04 Buy
Biosynth FA67713 2-Amino-4-fluorobenzonitrile 80517-22-2 400g $9148 2026-06-04 Buy
Apolloscientific PC5484 2-Amino-4-fluorobenzonitrile 98% 80517-22-2 1g $21 2026-06-04 Buy
Apolloscientific PC5484 2-Amino-4-fluorobenzonitrile 98% 80517-22-2 5g $33 2026-06-04 Buy
Product number Packaging Price Buy
FA67713 25g $150 Buy
FA67713 50g $227.5 Buy
FA67713 400g $9148 Buy
PC5484 1g $21 Buy
PC5484 5g $33 Buy

2-Amino-4-fluorobenzonitrile Chemical Properties,Uses,Production

Uses

2-Amino-4-fluorobenzonitrile is a useful research chemical for organic synthesis and other chemical processes.

Synthesis

2,4-Difluorobenzonitrile

3939-09-1

2-AMINO-4-FLUOROBENZONITRILE

80517-22-2

4-AMINO-2-FLUOROBENZONITRILE

53312-80-4

Using 2,4-difluorobenzonitrile (2.78 g, 20 mmol) and 3,4,5-trimethoxybenzylamine (3.94 g, 20 mmol) as raw material, the two were mixed and heated at 140 °C for 40 min. After completion of the reaction, the mixture was cooled to room temperature and subsequently dissolved in trifluoroacetic acid (TFA, 20 mL) and stirred at room temperature overnight. Afterwards, the mixture was concentrated using a rotary evaporator and subsequently partitioned between 1N NaOH solution (~100 mL, adjusted to alkaline) and ethyl acetate (100 mL). After separation of the organic layer, the aqueous layer was extracted with additional ethyl acetate (100 mL). All organic layers were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give an oil. Separation of the mixture by column chromatography (eluent: 10% to 40% hexane solution of ethyl acetate) gave two well separated isomeric products. Further concentration gave 4-amino-2-fluorobenzonitrile (1.07 g, 39% yield) as a white solid. The structure of the product was confirmed by LC/MS (m/z = 177.8, corresponding to the determination of [M+H]+ in acetonitrile).

References

[1] Patent: US2008/76813, 2008, A1. Location in patent: Page/Page column 28

2-Amino-4-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

2,4-Difluorobenzonitrile 4-Amino-2-fluorobenzonitrile

Preparation Products

2,4-Dichloro-7-fluoroquinazoline 7-Fluoroquinazoline-2,4(1H,3H)-dione

2-Amino-4-fluorobenzonitrile Suppliers

Global( 149)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
China Langchem Inc. 0086-21-58956006 China 7798 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
Shandong Xiya Chemical Co., Ltd 57
China Langchem Inc. 57

View Lastest Price from 2-Amino-4-fluorobenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-4-FLUOROBENZONITRILE pictures 2026-03-20 2-AMINO-4-FLUOROBENZONITRILE
80517-22-2
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-AMINO-4-FLUOROBENZONITRILE pictures 2024-04-25 2-AMINO-4-FLUOROBENZONITRILE
80517-22-2
 $30.00-100.00 1kg 99.93% 1000kg per week Ouhuang Engineering Materials (Hubei) Co., Ltd
2-Amino-4-fluorobenzonitrile pictures 2024-02-15 2-Amino-4-fluorobenzonitrile
80517-22-2
 $580.00 1g 98 500 Kg R&D Scientific Inc.

2-Amino-4-fluorobenzonitrile Spectrum

2-AMINO-4-FLUOROBENZONITRILE(80517-22-2)1HNMR

80517-22-2(2-Amino-4-fluorobenzonitrile)Related Search:

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