ChemicalBook >> CAS DataBase List >>1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]-

1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]-

1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- structure

CAS No.: 2742707-47-5

Chemical Name:: 1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]-

Synonyms: AChE/BuChE-IN-3;1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]-

CBNumber:: CB112666299

Molecular Formula:: C30H30F3N3O6

Molecular Weight:: 585.57

MDL Number:

MOL File:: 2742707-47-5.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:34

Request For Quotation

1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- Properties

Boiling point	699.6±65.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
pka	0.15±0.10(Predicted)

1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- Chemical Properties, Uses, Production

Uses

AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1].

IC 50

AChE: 0.65 μM (IC₅₀); BChE: 5.77 μM (IC₅₀)

References

[1] Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917. DOI:10.1016/j.bioorg.2020.103917

1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2742707-47-5 (1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]-) Related Search:

Lecanemab (Mouse IGG2a)

1H-1,2,3-Triazole, 4-[[[3,4-dihydro-5-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-1-benzopyran-7-yl]oxy]methyl]-1-[[4-(trifluoromethyl)phenyl]methyl]- AChE/BuChE-IN-3 2742707-47-5