Wandonorm
- CAS No.
- 82857-38-3
- Chemical Name:
- Wandonorm
- Synonyms
- LT 31-200;Wandonorm;Cyclobenzaprine-d;Bopindolol hydrogen malonate;Propanedioic acid, compd. with 2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1);Propanedioic acid, compd. with (+-)-2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1);2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), propanedioate (1:1) (salt) (9CI);2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), (+-)-, propanedioate (1:1) (salt)
- CBNumber:
- CB11270445
- Molecular Formula:
- C26H32N2O7
- Molecular Weight:
- 484.54148
- MDL Number:
- MFCD00798228
- MOL File:
- 82857-38-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Water: 5mM |
| form | White solid. |
| FDA UNII | S3UWR70991 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H302 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Wandonorm price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23365 | Bopindolol (malonate) ≥98% | 82857-38-3 | 100mg | $101 | 2026-04-30 | Buy |
| Cayman Chemical | 23365 | Bopindolol (malonate) ≥98% | 82857-38-3 | 500mg | $351 | 2026-04-30 | Buy |
| ChemScene | CS-0015630 | Bopindolol malonate 98.3% | 82857-38-3 | 25mg | $91 | 2026-06-04 | Buy |
| ChemScene | CS-0015630 | Bopindolol malonate 98.3% | 82857-38-3 | 50mg | $145 | 2026-06-04 | Buy |
| ChemScene | CS-0015630 | Bopindolol malonate 98.3% | 82857-38-3 | 100mg | $232 | 2026-06-04 | Buy |
Wandonorm Chemical Properties, Uses, Production
Uses
Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.
Definition
ChEBI: Bopindolol malonate is a benzoate ester.
in vivo
Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1]. Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate[2].
| Animal Model: | Male Wistar rats (260-300 g)[2] |
| Dosage: | 0.3, 1 and 3 mg/kg |
| Administration: | IP; single dosage |
| Result: | Produced dose dependent decreases in diastolic blood pressure, and the decrease of about 8 mmHg at 3 mg/kg. Decreased the heart rate in a dose-dependent manner. |
References
[1] Harron DW, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1991 Jan;41(1):130-49. DOI:10.2165/00003495-199141010-00010
[2] H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24(2):373-5. DOI:10.1016/0306-3623(93)90319-s
[3] Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18(8):1066-71. DOI:10.1248/bpb.18.1066
[4] Nagatomo T, et al. Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev. 2001 Spring;19(1):9-24. DOI:10.1111/j.1527-3466.2001.tb00180.x
Wandonorm Preparation Products And Raw materials
Raw materials
Preparation Products
Wandonorm Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
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