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Tizanidine hydrochloride

Tizanidine hydrochloride Structure
Tizanidine hydrochloride structure
CAS No.
64461-82-1
Chemical Name:
Tizanidine hydrochloride
Synonyms
TIZANIDINE HCL;AB-021;Gibonz;Zanpeak;TERNELIN;SIRDALUD;ZANAFLEX;Enchinin;Astonelin;DS-103-282
CBNumber:
CB8480703
Molecular Formula:
C9H9Cl2N5S
Molecular Weight:
290.17
MDL Number:
MFCD00798231
MOL File:
64461-82-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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Tizanidine hydrochloride Properties

Melting point 280 °C
Flash point 9℃
storage temp. Inert atmosphere,Room Temperature
solubility H2O: ~29 mg/mL
form solid
color white
Water Solubility H2O: >20mg/mL
Merck 14,9485
InChI InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
InChIKey ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
SMILES N1=C2C=CC(Cl)=C(NC3NCCN=3)C2=NS1.[H]Cl
CAS DataBase Reference 64461-82-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII B53E3NMY5C
NCI Drug Dictionary tizanidine hydrochloride
UNSPSC Code 41116107
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36-37/39
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  DK9910000
HS Code  2934990002
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

Tizanidine hydrochloride price More Price(83)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001700 Tizanidine hydrochloride European Pharmacopoeia (EP) Reference Standard 64461-82-1 100 mg $241 2026-04-30 Buy
Sigma-Aldrich T-085 Tizanidine hydrochloride 500?μg/mL in methanol, certified reference material, Cerilliant? 64461-82-1 1mL $105 2026-04-30 Buy
Sigma-Aldrich 1667905 Tizanidine hydrochloride United States Pharmacopeia (USP) Reference Standard 64461-82-1 200mg $675 2026-04-30 Buy
TCI Chemical T2527 Tizanidine Hydrochloride >98.0%(HPLC)(T) 64461-82-1 5g $49 2026-04-30 Buy
TCI Chemical T2527 Tizanidine Hydrochloride >98.0%(HPLC)(T) 64461-82-1 25g $130 2026-04-30 Buy
Product number Packaging Price Buy
Y0001700 100 mg $241 Buy
T-085 1mL $105 Buy
1667905 200mg $675 Buy
T2527 5g $49 Buy
T2527 25g $130 Buy

Tizanidine hydrochloride Chemical Properties, Uses, Production

Description

As an adrenergic agonist with muscle relaxant activity, tizanidine hydrochloride belongs to the hydrochloride salt form of tizanidine, which is commonly used in the treatment of spasticity, a condition where muscles in human body spasm, cramp, or become tight induced by a variety of medical problems such as multiple sclerosis, spinal cord injury, Lou Gehrig's disease, spastic diplegia, back pain or certain other injuries to the spine or central nervous system. Besides, as a sleep aid and an anticonvulsant, tizanidine hydrochloride has off-label usage for migraine headaches and is effective for some symptoms of fibromyalgia.
As a short-acting muscle relaxer, the antinociceptive effect of tizanidine hydrochloride functions by blocking excess nerve impulses (pain sensations) of the nerve cells that are sent to the brain and control muscle movement, ultimately resulting in muscle relaxation and spasticity alleviation.

References

https://en.wikipedia.org/wiki/Tizanidine
http://www.webmd.com/drugs/2/drug-1024/tizanidine-oral/details
http://bodyandhealth.canada.com/drug/getdrug/pal-tizanidine
https://pubchem.ncbi.nlm.nih.gov/compound/114869#section=Top
https://www.drugs.com/tizanidine.html

Chemical Properties

Off-White to pale Yellow Solid

Originator

Nimzox,Rapross Pharmaceuticals Pvt. Ltd.,India

Uses

An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal).

Uses

Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia,

Uses

Anticoagulant

Definition

ChEBI: Tizanidine hydrochloride is a benzothiadiazole.

Manufacturing Process

14 ml of benzoyl chloride are added to a solution of 11.5 g of ammonium thiocyanate in 150 ml of acetone in an ice bath and the mixture is then stirred for 10 min. This solution is heated to the boil at reflux together with 19 g of 4-amino-5-chloro-2,1,3-benzothiadiazole. The solution is cooled to room temperature and diluted with a 4-fold quantity of water. The precipitate is filtered off and rapidly brought to a boil together with 150 ml of a 2 N aqueous sodium hydroxide solution and kept at the boil for 5 min. The solution is cooled to room temperature, is acidified weakly with glacial acetic acid, the precipitate is filtered off, washed with ether and recrystallized from methanol. The N-(5-chloro-2,1,3-benzothiadiazol-4-yl)thiourea, obtained and this is boiled for 1 h together with 9 g of methyl iodide in 150 ml of methanol. After concentrating by evaporation, crude S-methyl-N-(5-chloro-2,1,3- benzothiadiazol-4-yl)isothiuronium iodide is obtained. 9.8 g of S-methyl-N-(5- chloro-2,1,3-benzothiadiazol-4-yl)isothiuronium iodide are heated to the boil at reflux for 1 h together with 50 ml of methanol and 1.8 ml of ethylene diamine. The solvent is then removed by evaporation and the moist residue is boiled at reflux for 1 h together with 20 ml of n-amyl alcohol. The mixture is subsequently shaken with 50 ml of chloroform and 150 ml of water until all the material is dissolved. 40 ml of a 2 N aqueous sodium hydroxide solution are added to the aqueous phase and extraction is effected with 200 ml of chloroform. The organic phase is dried and concentrated by evaporation. After recrystallizing the residue from methanol with the addition of some active charcoal, 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole, having a melting point of 221-223°C, is obtained. The 4-(2-imidazolin-2-yl-amino)-5-chloro-2,1,3-benzothiadiazole hydrochloride may be obtained by the teaction of 4-(2-imidazolin-2-yl-amino)-5-chloro- 2,1,3-benzothiadiazole with hydrochloric acid.

brand name

Tizanidine is INN and BAN.

Therapeutic Function

Muscle relaxant, Spasmolytic

Biological Activity

α 2 -adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC 50 = 48 nM). Also binds to imidazoline receptor.

storage

Desiccate at RT

References

[1] Patent: CN107778307, 2018, A. Location in patent: Paragraph 0044-0046; 0047-0048; 0049-0050
[2] Patent: CN106946874, 2017, A. Location in patent: Paragraph 0038-0040; 0041-0043; 0044-0046

Tizanidine hydrochloride Preparation Products And Raw materials

Raw materials

Iodomethane Benzoyl chloride Sodium hydroxide Hydrochloric acid 2,1,3-Benzothiadiazole
Ammonium thiocyanate Ethylenediamine Tizanidine 1-Acetyl-2-imidazolidinone 4-Amino-5-chloro-2,1,3-benzothiadiazole

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Preparation Products

Tizanidine hydrochloride Suppliers

Global Suppliers ( 302)
Supplier Tel Email Country ProdList Advantage
Sichuan Credit Chemwerth Pharmaceutical Co., Ltd. -- China 15 50
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Syntechem Co.,Ltd info@syntechem.com China 12973 57
China Langchem Inc. 0086-21-58956006 China 7798 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Supplier Advantage
Sichuan Credit Chemwerth Pharmaceutical Co., Ltd. 50
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Chemsky（shanghai）International Co.,Ltd. 50
Syntechem Co.,Ltd 57
China Langchem Inc. 57
Sinopharm Chemical Reagent Co,Ltd. 79

Related articles

View Latest Price from Tizanidine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tizanidine hydrochloride pictures 2026-08-12 Tizanidine hydrochloride
64461-82-1
 $1300.00 1KG 99 1T Baoji Guokang Healthchem Co., Ltd.
Tizanidine hydrochloride pictures 2026-07-15 Tizanidine hydrochloride
64461-82-1
 $47.00-87.00 99.96% 10g TargetMol Chemicals Inc.
Tizanidine hydrochloride pictures 2026-07-15 Tizanidine hydrochloride
64461-82-1
 $47.00-87.00 99.96% 10g TargetMol Chemicals Inc.

Tizanidine hydrochloride Spectrum

Tizanidine hydrochloride(64461-82-1)1HNMR

64461-82-1 (Tizanidine hydrochloride) Related Search:

Bis(2-ethylhexyl)amine Moxonidine hydrochloride Clonidine hydrochloride DL-Octopamine hydrochloride 2-Aminoethylammonium chloride
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Methoxyammonium chloride Dihydromyrcenol Olopatadine HCl Diethanolamine hydrochloride Ethanolamine hydrochloride
p-Toluenesulfonic acid 4-Amino-5-chloro-2,1,3-benzothiadiazole (5-Chloro-2,1,3-benzothiadiazol-4-yl)-cyanaMide

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5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2 1,3-benzothiadiazol-4-amine,5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-mono 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazolehydrochloride SIRDALUD TERNELIN TIZANIDINE HYDROCHLORIDE ZANAFLEX DS-103-282 AB-021 TizanidineHydrochloride(Patent) 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine, Hydrochloride, AB-021, DS-103-282, Sirdalud, Ternelin, Zanaflex 5-Chloro-4-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2,1,3-benzothiadiazole Hydrochloride 5-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOL-4-AMINE HYDROCHLORIDE 5-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOLE-4-AMINE HYDROCHLORIDE Astonelin Enchinin Gibonz Zanpeak 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride Unii-B53E3nmy5c Tizanidinechlorhydrate Tizanidine Hydrochloride, USP Tizanidine Hydrochloride (200 mg) 2,1,3-Benzothiadiazol-4-aMine,5-chloro-N-(4,5-dihydro-1H-iMidazol-2-yl)-, hydrochloride (1:1) 2-[2-({[5-(diethylamino)pentan-2-yl]amino}methyl)-1-azabicyclo[2.2.2]oct-3-yl]ethanol Tizanidine hydrochloride CRS Tizanidine impurity B CRS Tizanidine hydrochloride salt Tizanidine hydrochloride USP/EP/BP Tizanidine HCl (BRN 0618691 Tizanidine HydrochlorideQ: What is Tizanidine Hydrochloride Q: What is the CAS Number of Tizanidine Hydrochloride Q: What is the storage condition of Tizanidine Hydrochloride Q: What are the applications of Tizanidine Hydrochloride Tizanidine Hydrochloride (1667905) Tizanidine hydrochloride, 10 mM in DMSO Tizanidine HCl - Bio-X ? Tizanidine hydrochloride 100 μg/mL in Acetonitrile TIZANIDINE HCL Tizanidine hydrochloride (Standard) Tizanidine hydrochloride ≥98% 64461-82-1 C9H8ClN5SClH C9H9Cl2N5S C9H8ClN5SHCl Zanaflex, Sirdalud Bases & Related Reagents Heterocycles Nucleotides Sulfur & Selenium Compounds Muscle relaxant (skeletal) Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Adrenoceptor 64461-82-1