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BIBS 39

BIBS 39 Structure
BIBS 39 structure
CAS No.
133085-33-3
Chemical Name:
BIBS 39
Synonyms
CS-2534;BIBS 39;BIBS 39; BIBS-39;2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid;4'-((2-butyl-6-(3-cyclohexylureido)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid;4'-({2-butyl-6-[(cyclohexylcarbamoyl)amino]-1H-1,3-benzodiazol-1-yl}methyl)-[1,1'-biphenyl]-2-carboxylic acid;[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-6-[[(cyclohexylamino)carbonyl]amino]-1H-benzimidazol-1-yl]methyl]-
CBNumber:
CB11322261
Molecular Formula:
C32H36N4O3
Molecular Weight:
524.65
MDL Number:
MOL File:
133085-33-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:00
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BIBS 39 Properties

Boiling point 729.1±60.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:30.0(Max Conc. mg/mL);57.18(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);57.18(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.48(Max Conc. mM)
form A crystalline solid
pka 3.84±0.36(Predicted)
color White to off-white
FDA UNII NV95PEF62M

BIBS 39 price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22932 BIBS39 ≥98% 133085-33-3 1mg $32 2026-04-30 Buy
Cayman Chemical 22932 BIBS39 ≥98% 133085-33-3 5mg $95 2026-04-30 Buy
Cayman Chemical 22932 BIBS39 ≥98% 133085-33-3 10mg $158 2026-04-30 Buy
Cayman Chemical 22932 BIBS39 ≥98% 133085-33-3 25mg $275 2026-04-30 Buy
Biosynth IFA08533 BIBS 39 133085-33-3 25mg $1164 2026-06-04 Buy
Product number Packaging Price Buy
22932 1mg $32 Buy
22932 5mg $95 Buy
22932 10mg $158 Buy
22932 25mg $275 Buy
IFA08533 25mg $1164 Buy

BIBS 39 Chemical Properties,Uses,Production

Uses

BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptor in vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 ± 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 ± 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 ± 7 nM for the AT1 subtype and a Ki value of 730 ± 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times. BIBS 39 shifts the AII concentration-contractile response curves in isolated rabbit aorta to the right in a parallel fashion. [1] in vivo: In pithed rats, BIBS 39 dependently shifts the dose-response curve of AII to the right without affecting the maximal response. BIBS 222 also causes parallel shifts to the right but a significant reduction of the maximal responses was observed at 3 and 10 mg/kg i.v. These results show that the benzimidazole derivatives BIBS 39 is a potent and selective AII receptor antagonists. Substitution with a benzimidazole moiety results into a considerable loss of selectivity for the AT1 receptor subtype compared with an imidazole moiety as, for instance, in DuP 753.[1] BIBS 39 is a new nonpeptide angiotensin receptor blockers that has affinity for both AT1- and AT2-receptors, is also a potent antagonist of the cardiovascular effects of AII in pithed rabbits. [2]

IC 50

AT2 Receptor; AT1 Receptor

References

[1] Zhang J, et al. Characterization of BIBS 39 and BIBS 222: two new nonpeptide angiotensin II receptor antagonists. Eur J Pharmacol. 1992 Jul 21;218(1):35-41. DOI:10.1016/0014-2999(92)90144-s
[2] Zhang J, et al. Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits. J Cardiovasc Pharmacol. 1995 May;25(5):724-31. DOI:10.1097/00005344-199505000-00007

BIBS 39 Preparation Products And Raw materials

Raw materials

Preparation Products

BIBS 39 Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
D&C Chemicals +86-21-58447131 1724405207@qq.com China 470 55
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
ShangHai Siyan Biological Technology Co., Ltd. 021-50908862，442785678，326799392 18721037013 siyansales@126.com China 9612 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Shanghai Resuperpharmtech Co., Ltd. 02150565560; 17321237488 kevin@resuperpharmtech.com China 353 58
Supplier Advantage
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
D&C Chemicals 55
Shanghai Synchem Pharma Co., ltd 55
ShangHai Siyan Biological Technology Co., Ltd. 58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Shanghai Resuperpharmtech Co., Ltd. 58

View Lastest Price from BIBS 39 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid pictures 2020-01-02 2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid
133085-33-3
 $1.00 1KG Min98% HPLC Career Henan Chemical Co

133085-33-3(BIBS 39)Related Search:

2-Methyl-1-phenyl-1H-benzoimidazole 1-Phenyl-1H-benzoimidazole 1-[1,1''-Biphenyl]-4-yl-1H-imidazole 1H-Benzimidazol-6-amine,2-ethyl-1-methyl- BIBS 39
1H-Benzimidazole,1-methyl-2-propyl-(9CI)

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BIBS 39 CS-2534 BIBS 39; BIBS-39 2-[4-[[2-butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid [1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-6-[[(cyclohexylamino)carbonyl]amino]-1H-benzimidazol-1-yl]methyl]- 4'-({2-butyl-6-[(cyclohexylcarbamoyl)amino]-1H-1,3-benzodiazol-1-yl}methyl)-[1,1'-biphenyl]-2-carboxylic acid 4'-((2-butyl-6-(3-cyclohexylureido)-1H-benzo[d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid 133085-33-3 C32H36N4O3