Cystamine-D8 2hcl
- CAS No.
- 2712126-51-5
- Chemical Name:
- Cystamine-D8 2hcl
- Synonyms
- Cystamine-d8 (dihydrochloridei(1/4);Cystamine-D8 Dihydrochloride (Standard);2-[(2-amino-1,1,2,2-tetradeuterioethyl)disulfanyl]-1,1,2,2-tetradeuterioethanamine
- CBNumber:
- CB113229141
- Molecular Formula:
- C4H13ClN2S2
- Molecular Weight:
- 188.73
- MDL Number:
- MOL File:
- 2712126-51-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H336-H402 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P273-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Cystamine-D8 2hcl price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26775 | Cystamine-d8 (hydrochloride) ≥99%deuteratedforms(d1-d8) | 2712126-51-5 | 500μg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 26775 | Cystamine-d8 (hydrochloride) ≥99%deuteratedforms(d1-d8) | 2712126-51-5 | 1mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 26775 | Cystamine-d8 (hydrochloride) ≥99%deuteratedforms(d1-d8) | 2712126-51-5 | 5mg | $255 | 2026-04-30 | Buy |
| Cayman Chemical | 26775 | Cystamine-d8 (hydrochloride) ≥99%deuteratedforms(d1-d8) | 2712126-51-5 | 10mg | $389 | 2026-04-30 | Buy |
| Cayman Chemical | 26775 | Cystamine-d8 (hydrochloride) ≥99% deuterated forms (d1-d8) | 2712126-51-5 | 500 μg | $37 | 2024-03-01 | Buy |
Cystamine-D8 2hcl Chemical Properties, Uses, Production
Description
Cystamine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cystamine by GC- or LC-MS. Cystamine is an organic disulfide that inhibits tissue transglutaminase (TGM2) with an IC50 value of approximately 2.5 mM.1 It is orally available and is neuroprotective in mouse models of Huntington’s disease.2,3 Cystamine also inhibits caspase-3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.4
Uses
Cystamine-d8 (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].
References
1. Smethurst, P.A., and Griffin, M. Measurement of tissue transglutaminase activity in a permeabilized cell system: Its regulation by Ca2+ and nucleotides Biochem. J. 313(pt 3),803-808(1996).
2. Dedeoglou, A., Kubilus, J.K., Jeitner, T.M., et al. Therapeutic effects of cystamine in a murine model of Huntington’s disease J. Neurosci. 22(20),8942-8950(2002).
3. Borrell-Pagès, M., Canals, K.P., Cordelièrs, F.P., et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase J. Clin. Invest. 116(5),1410-1424(2006).
4. Elli, L., Ciulla, M.M., Busca, G., et al. Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease Lab. Invest. 91(3),452-461(2011).
Cystamine-D8 2hcl Preparation Products And Raw materials
Raw materials
Preparation Products
Cystamine-D8 2hcl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 4979 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | offer.de@lgcgroup.com | China | 19036 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| Supplier | Advantage |
|---|---|
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 58 |
| LGC Science (Shanghai) Ltd. | 58 |
| CHINA ISOTOPE CO., LIMITED | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol | 58 |
