nimbolide
- CAS No.
- 25990-37-8
- Chemical Name:
- nimbolide
- Synonyms
- nimbolide;NSC 309909;Nimbolide (25 mg);Nimbolide, 10 mM in DMSO;Nimbolide, CyclinA and ERK1/2 inhibitor;(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone;methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate;2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
- CBNumber:
- CB11328652
- Molecular Formula:
- C27H30O7
- Molecular Weight:
- 466.52
- MDL Number:
- MFCD31924824
- MOL File:
- 25990-37-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >223°C (dec.) |
|---|---|
| Boiling point | 608.6±55.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform, Ethyl Acetate |
| form | powder |
| color | Light Beige to Yellow |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChIKey | KMTFKEPRKBPCJW-UHFFFAOYSA-N |
| SMILES | C12C3(C)C=CC(=O)C1(C)C(CC(=O)OC)C1(C)C4C(C(C=C4C)C4=COC=C4)OC1C2OC3=O |
| FDA UNII | N993G4LGD6 |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| RTECS | GY2370000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | hamster,LD50,intraperitoneal,> 500mg/kg (500mg/kg),Toxicology Letters. Vol. 30, Pg. 159, 1986. | |||||||||
| NFPA 704 |
|
nimbolide price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00586 | Nimbolide from Azadirachta indica, ≥98% | 25990-37-8 | 5mg | $407.25 | 2026-04-30 | Buy |
| Cayman Chemical | 19230 | Nimbolide ≥97% | 25990-37-8 | 5mg | $277 | 2026-04-30 | Buy |
| Cayman Chemical | 19230 | Nimbolide ≥97% | 25990-37-8 | 25mg | $1164 | 2026-04-30 | Buy |
| Biosynth | XN164985 | Nimbolide | 25990-37-8 | 2mg | $190.38 | 2026-06-05 | Buy |
| Biosynth | XN164985 | Nimbolide | 25990-37-8 | 5mg | $380.95 | 2026-06-05 | Buy |
nimbolide Chemical Properties, Uses, Production
Chemical Properties
Light Beige Solid
Uses
Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong growth inhibition.
Biological Activity
Nimbolide exhibits anti-malarial, anti-bacterial, and anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cells, nimbolide induced cell cycle arrest, DNA damage, and apoptosis.It has been shown to modulate autophagy and apoptosis in pancreatic cancer.
in vivo
Nimbolide (10 mg/kg, i.v., daily, 7 days) inhibits glioblastoma multiforme tumor growth in U87EGFRvⅢ xenografted mouse model[2].
Nimbolide (5 mg/kg, 20 mg/kg; i.p.; daily, 10 days), inhibits tumor growth in HCT-116-derived xenograft mouse, reduces the expression of proteins involved in invasion, metastasis, and angiogenesis (MMP-9, CXCR4, ICAM-1, and VEGF)[5].
| Animal Model: | HCT-116-derived xenograft mouse[5] |
| Dosage: | 5 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), daily, 10 days |
| Result: | Suppressed tumor growth in nude mice at a dose as low as 5 mg/kg. Reduced tumor growth by almost 90% on day 10 at a dose as low as 20 mg/kg. Didn’t affect the body weight of mice. |
IC 50
NF-κB; CDK4; CDK6
storage
Store at -20°C
nimbolide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4593 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5550 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
