ChemicalBook >> CAS DataBase List >>2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone

2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone

2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone structure

CAS No.: 2768485-08-9

Chemical Name:: 2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone

Synonyms: 2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone

CBNumber:: CB113461620

Molecular Formula:: C21H24N4O4S

Molecular Weight:: 428.51

MDL Number:

MOL File:: 2768485-08-9.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:37

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2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone Properties

Boiling point	656.6±65.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka	1.40±0.10(Predicted)

2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone Chemical Properties, Uses, Production

Uses

Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC50 value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases[ 1].

References

[1] Chen L, et al. Concise synthesis and preliminary biological evaluation of new triazolylthioacetone derivatives bearing pyridine, pyrazine, and 3,4,5-trimethoxybenzyl fragment. Bioorg Med Chem Lett. 2022;66:128721. DOI:10.1016/j.bmcl.2022.128721

2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2768485-08-9 (2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone) Related Search:

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2-[[4-Amino-5-[(3,4,5-trimethoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl]thio]-1-(4-methylphenyl)ethanone 2768485-08-9