garcinol
- CAS No.
- 78824-30-3
- Chemical Name:
- garcinol
- Synonyms
- 802;Camboginol;CP-54;garcinol;HSDB 7825;Garcinol, 10 mM in DMSO;Garcinol, HAT p300 and PCAF inhibitor;(1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione;(1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (1R,5R,7R)-
- CBNumber:
- CB11347121
- Molecular Formula:
- C38H50O6
- Molecular Weight:
- 602.8
- MDL Number:
- MFCD03700761
- MOL File:
- 78824-30-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 132 °C |
|---|---|
| Boiling point | 710.8±60.0 °C(Predicted) |
| Density | 1.114±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | Yellow solid. |
| pka | 4.50±1.00(Predicted) |
| color | Yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Garcinol is prone to oxidation. Protect from exposure to air. |
| LogP | 11.546 (est) |
| FDA UNII | TR1VR1V71B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330 | |||||||||
| Precautionary statements | P260-P262-P264-P270-P271-P280-P284-P301+P310-P330-P302+P352-P304+P340-P320-P361+P364-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
garcinol price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10566 | Garcinol ≥95% | 78824-30-3 | 5mg | $47 | 2026-04-30 | Buy |
| Cayman Chemical | 10566 | Garcinol ≥95% | 78824-30-3 | 10mg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 10566 | Garcinol ≥95% | 78824-30-3 | 25mg | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 10566 | Garcinol ≥95% | 78824-30-3 | 50mg | $301 | 2026-04-30 | Buy |
| Usbiological | 255360 | Garcinol (Camboginol, CCRIS 9029, CHEMBL502489) ≥98%(TLC) | 78824-30-3 | 10mg | $368 | 2026-06-03 | Buy |
garcinol Chemical Properties, Uses, Production
Description
Garcinol (78824-30-3) is a HAT (histone acetyltransferase) inhibitor (p300 IC50=7 μM and PCAF IC50=5 μM) both in vitro and in vivo.1 It potentiates TRAIL-induced apoptosis of cancer cells. In cancer cells garcinol, independent of the cell type, induces both of the TRAIL receptors, death receptor 4 (DR4) and DR5. Garcinol neither induces the receptors of normal cells nor sensitizes them to TRAIL.2
Uses
Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively). It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth. A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.
Uses
Garcinol is a small molecule inhibitor of histone acetyltransferases. Used in cancer therapy. Garcinol, harvested from Garcinia indica.
Definition
ChEBI: Garcinol is a monoterpenoid.
in vivo
Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth[3].
| Animal Model: | Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors[3] |
| Dosage: | 1 and 2 mg/kg |
| Administration: | I.p.; five times/week for 4 consecutive weeks |
| Result: | Induced significant inhibition of tumor growth. |
IC 50
AChE; BChE; GCN5/PCAF; Human Endogenous Metabolite
References
[1] KARANAM BALASUBRAMANYAM. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.[J]. The Journal of Biological Chemistry, 2004, 279 32: 33716-33726. DOI:10.1074/jbc.m402839200
[2] SAHDEO PRASAD. Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins.[J]. Molecular Cancer Therapeutics, 2010, 9 4: 856-868. DOI:10.1158/1535-7163.mct-09-1113
garcinol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 587 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai ChengShao Biological Technology Co., Ltd. | 021-61847300 13341622919 | shcss01@163.com | China | 4806 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
