Methyl 4-bromopyrrole-2-carboxylate
- CAS No.
- 934-05-4
- Chemical Name:
- Methyl 4-bromopyrrole-2-carboxylate
- Synonyms
- METHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE;4-Bromo-1H-pyrrole-2-carboxylic acid methyl ester;RARECHEM AL BF 1264;METHYL 4-BROMOPYRROLE-2-CARBOXYLATE;4-Bromo-2-(methoxycarbonyl)-1H-pyrrole;Methyl 4-Bromopyrrole-2-carboxylate >Methyl 4-BroMopyrrole-2-carboxylate, 97+%;Methyl 4-bromo-1H-pyrrole-2-carboxylate 97+%;4-Bromopyrrole-2-carboxylic Acid Methyl Ester;Methyl 4-bromopyrrole-2-carboxylate, 10 mM in DMSO
- CBNumber:
- CB1136108
- Molecular Formula:
- C6H6BrNO2
- Molecular Weight:
- 204.02
- MDL Number:
- MFCD00832855
- MOL File:
- 934-05-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 100-101°C |
|---|---|
| Boiling point | 290.5±20.0 °C(Predicted) |
| Density | 1.674±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 13.49±0.50(Predicted) |
| color | White to Orange to Green |
| λmax | 271nm(MeOH)(lit.) |
| InChI | InChI=1S/C6H6BrNO2/c1-10-6(9)5-2-4(7)3-8-5/h2-3,8H,1H3 |
| InChIKey | ZXFCRVGOHJHZNF-UHFFFAOYSA-N |
| SMILES | N1C=C(Br)C=C1C(OC)=O |
| CAS DataBase Reference | 934-05-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Methyl 4-bromopyrrole-2-carboxylate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2583 | Methyl 4-Bromopyrrole-2-carboxylate >98.0%(GC) | 934-05-4 | 1g | $36 | 2026-04-30 | Buy |
| TCI Chemical | M2583 | Methyl 4-Bromopyrrole-2-carboxylate >98.0%(GC) | 934-05-4 | 5g | $141 | 2026-04-30 | Buy |
| Usbiological | 430640 | 4-Bromo-1H-pyrrole-2-carboxylic Acid Methyl Ester | 934-05-4 | 2.5g | $403 | 2026-06-03 | Buy |
| Usbiological | 430640 | 4-Bromo-1H-pyrrole-2-carboxylic Acid Methyl Ester | 934-05-4 | 10g | $566 | 2026-06-03 | Buy |
| AstaTech | CL2807 | METHYL4-BROMO-1H-PYRROLE-2-CARBOXYLATE 97% | 934-05-4 | 5G | $46 | 2026-04-30 | Buy |
Methyl 4-bromopyrrole-2-carboxylate Chemical Properties, Uses, Production
Chemical Properties
Off-white powder
Uses
4-Bromo-1H-pyrrole-2-carboxylic Acid Methyl Ester is a useful synthetic intermediate. It is used to synthesize potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone.
Synthesis
67-56-1
72652-32-5
124-41-4
934-05-4
Example 1C. Synthesis of 4-bromo-2-methoxycarbonylpyrrole: To a solution of methanol (100 mL) containing 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroacetophenone (20 g, 68 mmol) was added slowly and dropwise sodium methanol (1M solution in methanol, 34 mL, 34 mmol). The reaction mixture was stirred at room temperature for 1 hour and then diluted with water (300 mL) to separate the organic layer. The aqueous phase was extracted with dichloromethane (CH2Cl2), and the combined organic layer and extract were washed with water (2 x 50 mL), dried over anhydrous magnesium sulfate (MgSO4), and concentrated under reduced pressure. The residue was recrystallized by hexane to give 4-bromo-2-methoxycarbonylpyrrole (12 g, 85% yield) as a white solid.LC-MS analysis showed [M-H]+ peak at 203.1.1.1H NMR (DMSO-d6, 400 MHz) data were as follows: δ 12.31 (broad single peak, 1H), 7.16 (single peak, 1H), 6.81 (single peak, 1H ), 3.75 (single peak, 3H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4412 - 4418
[2] Patent: WO2010/42682, 2010, A1. Location in patent: Page/Page column 50
[3] Patent: US2006/293320, 2006, A1. Location in patent: Page/Page column 25; 35
Methyl 4-bromopyrrole-2-carboxylate Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JINAN MEIGAO BIOPHARMATECH CO. LTD | 13853286203 18205419756 | shy96321@163.com | China | 20 | 58 |
| Aloespharm Co., Ltd. | 021-20960837 | market@aloespharm.com | China | 1299 | 55 |
| Changzhou Langyi Biomedical Technology Co., Ltd. | 13706129682 | tiffany@langyupharm.com | China | 90 | 58 |
| Qingdao Port Liwei Import and Export Co., Ltd | 13853286203 13853286203 | shy96321@163.com | China | 40 | 58 |
| shandong zhogntaihe | 13223931914 13864082898 | 3577057603@qq.com | China | 500 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Methyl 4-bromopyrrole-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Methyl 4-bromopyrrole-2-carboxylate
934-05-4
|
$29.00 | 99.66% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-22 | Methyl 4-bromo-1H-pyrrole-2-carboxylate
934-05-4
|
1KG | 97.1% | 100 tons | Honest Joy Holdings Limited | ||
 |
2021-08-12 | Methyl 4-bromopyrrole-2-carboxylate
934-05-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Methyl 4-bromopyrrole-2-carboxylate
934-05-4
- $29.00
- 99.66%
- TargetMol Chemicals Inc.
-
- Methyl 4-bromo-1H-pyrrole-2-carboxylate
934-05-4
- $0.00
- 97.1%
- Honest Joy Holdings Limited
-
- Methyl 4-bromopyrrole-2-carboxylate
934-05-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
