Methyl 2-pyrrolecarboxylate
- CAS No.
- 1193-62-0
- Chemical Name:
- Methyl 2-pyrrolecarboxylate
- Synonyms
- METHYL 1H-PYRROLE-2-CARBOXYLATE;RARECHEM AL BF 0174;2 - pyrrole Methyl forMate;METHYL 2-PYRROLECARBOXYLATE;Methyl 1H-pyrrol-2-carboxylate;MethylPyrrole-2-carboxylate>Methyl 2-pyrrolecarboxylate 97%;Pyrrole-2-carboxylic Acid Methyl Ester;1H-Pyrrole-2-carboxylic acid,methyl ester
- CBNumber:
- CB5485404
- Molecular Formula:
- C6H7NO2
- Molecular Weight:
- 125.13
- MDL Number:
- MFCD00817048
- MOL File:
- 1193-62-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 74-78 °C(lit.) |
|---|---|
| Boiling point | 104-105 °C(Press: 9 Torr) |
| Density | 1.184±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 15.16±0.50(Predicted) |
| color | Light Beige |
| Water Solubility | Soluble in water. |
| InChI | InChI=1S/C6H7NO2/c1-9-6(8)5-3-2-4-7-5/h2-4,7H,1H3 |
| InChIKey | VONGYFFEWFJHNP-UHFFFAOYSA-N |
| SMILES | N1C=CC=C1C(OC)=O |
| LogP | 1.170 |
| FDA UNII | 3BEG2CK3LU |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 2-pyrrolecarboxylate price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 640425 | Methyl 2-pyrrolecarboxylate 97% | 1193-62-0 | 5g | $120 | 2026-04-30 | Buy |
| Sigma-Aldrich | 640425 | Methyl 2-pyrrolecarboxylate 97% | 1193-62-0 | 25g | $171 | 2026-04-30 | Buy |
| TCI Chemical | M2160 | Methyl Pyrrole-2-carboxylate >98.0%(GC) | 1193-62-0 | 5g | $34 | 2026-04-30 | Buy |
| TCI Chemical | M2160 | Methyl Pyrrole-2-carboxylate >98.0%(GC) | 1193-62-0 | 25g | $118 | 2026-04-30 | Buy |
| Usbiological | 454703 | Methyl 1H-Pyrrole-2-carboxylate | 1193-62-0 | 1g | $312 | 2026-06-03 | Buy |
Methyl 2-pyrrolecarboxylate Chemical Properties, Uses, Production
Description
Methyl 2-pyrrolecarboxylate is a crystalline or powder,It can be used as an organic reagent and can be obtained by the reaction of pyrrole with dimethyl carbonate.
Uses
Methyl 1H-Pyrrole-2-carboxylate is an intermediate used to prepare pyrrolyl aryl sulfones with activity against HIV-1. It is also used in the synthesis of diaryl pyrrolecarboxylates as combretastatin A-4/lamellarin T hybrids with anti-mitotic and cytotoxic activity.
Definition
ChEBI: Methyl 1H-pyrrole-2-carboxylate is a member of pyrroles.
Synthesis
67-56-1
634-97-9
1193-62-0
50 mL of SOCl2 was slowly added dropwise to a solution of pyrrole-2-carboxylic acid (1) (16.65 g, 0.15 mol) dissolved in 10 mL of MeOH at 0 °C for a controlled time of 30 min. Subsequently, the reaction mixture was warmed up to 35 °C with continuous stirring for 24 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation, and the resulting residue was purified by column chromatography with the eluent being a mixed solvent of ethyl acetate/petroleum ether, which ultimately afforded Intermediate 2 as a white solid in 85% yield with a melting point of 72-73 °C.
References
[1] Canadian Journal of Chemistry, 2002, vol. 80, # 12, p. 1662 - 1667
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 22, p. 7091 - 7100
[3] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 20, p. 2997 - 3003
[4] Patent: EP1386913, 2004, A1. Location in patent: Page 88
[5] Patent: EP986382, 2008, B1. Location in patent: Page/Page column 23
Methyl 2-pyrrolecarboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou hanergy Biotechnology Co., Ltd | 13915872857 | hannengchemical@163.com | China | 117 | 58 |
| THchemica Co.,Ltd. | 0573-82835115 18969301519 | tly1019@126.com | China | 276 | 58 |
| Taizhou Guoci Pharmaceutical Technology Co. LTD | 13575460036 | 921220106@qq.com | China | 64 | 58 |
| Qingdao Fansen Biotechnology Co., Ltd | 18661607483 | qddxhn@163.com | China | 209 | 58 |
| Shandong utilizing biological technology co., LTD | 18669728830 15966937598 | 3407650895@qq.com | China | 5167 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from Methyl 2-pyrrolecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-14 | Methyl 1H-pyrrole-2-carboxylate
1193-62-0
|
$5.00 | 1kg | ≥98% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-07 | Methyl 2-pyrrolecarboxylate
1193-62-0
|
1kg | 99%min | 2000KGS | HANGZHOU HAILAN CHEMICAL CO.,LTD. | ||
 |
2026-08-25 | Methyl 2-pyrrolecarboxylate
1193-62-0
|
$12.00-200.00 | 5g | 99% | 50 | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- Methyl 1H-pyrrole-2-carboxylate
1193-62-0
- $5.00
- ≥98%
- Jinan Finer Chemical Co., Ltd
-
- Methyl 2-pyrrolecarboxylate
1193-62-0
- $0.00
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
-
- Methyl 2-pyrrolecarboxylate
1193-62-0
- $12.00-200.00
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
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