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Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside structure

CAS No.: 4099-85-8

Chemical Name:: Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside

Synonyms: Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside;((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol;NSC 85191;EINECS 223-865-8;Capecitabine Impurity 32;Capecitabine Impurity 55;2,3-O-Isopropylidene-B-D-ribofuranoside;METHYL 2,3-O-ISOPROPYLIDEN-D-RIBOFURANOSE;(3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-te;2,3-O-isopropylidine-1-O-methylribofuranose

CBNumber:: CB1140967

Molecular Formula:: C9H16O5

Molecular Weight:: 204.22

MDL Number:: MFCD00270040

MOL File:: 4099-85-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:08:07

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Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Properties

Boiling point	75°C/0.3mm
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in chloroform, dichloromethane, ethanol, ethyl acetate, and methanol
pka	14.14±0.10(Predicted)
form	Oil
color	Clear Yellow
InChI	InChI=1/C9H16O5/c1-9(2)13-6-5(4-10)12-8(11-3)7(6)14-9/h5-8,10H,4H2,1-3H3/t5-,6-,7-,8-/s3
InChIKey	DXBHDBLZPXQALN-OVDRDRJSNA-N
SMILES	C([C@H]1O[C@@H](OC)[C@]2([H])OC(C)(C)O[C@]12[H])O \|&1:1,3,6,13,r\|
CAS DataBase Reference	4099-85-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code	2940006000

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3528	Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside min. 98.0 %	4099-85-8	1G	$22	2026-04-30	Buy
TCI Chemical	M3528	Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside min. 98.0 %	4099-85-8	5G	$74	2026-04-30	Buy
TRC	TRC-M314600-5G	Methyl 2,3-O-Isopropylidene-Beta-D-ribofuranoside	4099-85-8	5g	$72	2026-06-03	Buy
Biosynth	MM03771	Methyl 2,3-O-isopropylidene-β-D-ribofuranoside	4099-85-8	25g	$240.75	2026-06-04	Buy
Biosynth	MM03771	Methyl 2,3-O-isopropylidene-β-D-ribofuranoside	4099-85-8	50g	$405	2026-06-04	Buy

Product number	Packaging	Price	Buy
M3528	1G	$22	Buy
M3528	5G	$74	Buy
TRC-M314600-5G	5g	$72	Buy
MM03771	25g	$240.75	Buy
MM03771	50g	$405	Buy

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Chemical Properties,Uses,Production

Chemical Properties

Colourless Liquid

Uses

Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside is used for the manufacture of fine chemicals, and Industrial use resulting in manufacture of intermediates.

Synthesis

67-56-1

532-20-7

67-64-1

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside

4099-85-8

D-ribose (1; 20.0 g, 133.2 mmol) was suspended in a solvent mixture of acetone (100 mL) and methanol (100 mL) at room temperature. Concentrated sulfuric acid (10 mL) was slowly added and the reaction mixture was stirred for 48 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, solid sodium bicarbonate (NaHCO3) was added to neutralize the reaction solution. The insoluble solids were removed by filtration and the filtrate was subsequently concentrated. The concentrated mixture was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and the solvent was evaporated to remove the organic solvent. The crude product was purified by silica gel fast column chromatography using hexane/ethyl acetate (5:1, v/v) as eluent to afford the target compound ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxin-4-yl)methanol as a light yellow oil in 24.4 g (90% yield). The Rf value of the product was 0.2 (eluent: hexane/EtOAc = 5:1, v/v). The specific optical rotation [α]D25 was -80.00 (c 1.00, CHCl3), which is in accordance with the literature value [α]D20 -75.00 (c 1.00, CHCl3).1H NMR (CDCl3, 400 MHz) data were as follows: δ= 4.97 (s, 1H), 4.83 (d, J = 5.7Hz, 1H), 4.58 (d, J = 6.0 Hz, 1H), 4.42 (t, J = 2.7 Hz, 1H), 3.56-3.72 (m, 2H), 3.43 (s, 3H), 3.32 (dd, J = 10.0,3.0 Hz, 1H), 1.49 (s, 3H), 1.32 (s, 3H).

References

[1] Synthesis (Germany), 2017, vol. 49, # 18, p. 4299 - 4302
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 7972 - 7990
[3] Journal of the American Chemical Society, 2015, vol. 137, # 10, p. 3558 - 3564
[4] Organic and Biomolecular Chemistry, 2009, vol. 7, # 4, p. 761 - 776
[5] Journal of Fluorine Chemistry, 1993, vol. 60, # 2.3, p. 239 - 250

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside synthesis

Synthesis of Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside from Methanol and D-Ribopyranose (9CI) and Acetone

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Preparation Products And Raw materials

Raw materials

Methanol D-Lyxofuranose (9CI) beta-D-Ribofuranose (9CI) b-D-Ribofuranose, 2,3-O-(1-Methylethylidene)- D-Ribose

2,2-Dimethoxypropane Acetone

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Preparation Products

5-Deoxy-D-ribose Benzo(g.h.i)perylene d12 Methyl 2,3-O-isopropylidene-5-O-benzyl-beta-D-ribofuranoside

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Suppliers

Global( 136)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Qinling Pharmaceutical Co., Ltd.	010-61241352 18901327973	834537306@qq.com	China	6234	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57

Supplier	Advantage
Beijing Qinling Pharmaceutical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Accela ChemBio Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57

View Lastest Price from Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside 4099-85-8		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-08-12	Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside 4099-85-8	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	Methyl-2,3-O–isopropylidene-β-D- ribofuranoside 4099-85-8	$90.00-100.00	1KG	99%	10kg/month or Customized	Career Henan Chemical Co

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
4099-85-8
98%
Henan Aochuang Chemical Co.,Ltd.

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
4099-85-8
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Methyl-2,3-O–isopropylidene-β-D- ribofuranoside
4099-85-8
$90.00-100.00
99%
Career Henan Chemical Co

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Spectrum

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside(4099-85-8)¹HNMR

4099-85-8(Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside)Related Search:

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Thiophanate-methyl Metsulfuron methyl Methyl Parathion-methyl 1,5-Di-O-(4-methylbenzoyl)-2,3-O-isopropylidene-beta-D-ribofuranose

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METHYL 2,3-O-ISOPROPYLIDEN-D-RIBOFURANOSE METHYL-2,3-O-ISOPROPYLIDENE-ALPHA,BETA-D-RIBOFURANOSIDE METHYL 2,3-O-ISOPROPYLIDENE-B-D-RIBOFURANOSIDE METHYL 2,3-O-ISOPROPYLIDENE-BETA-D-RIBOFURANOSIDE EINECS 223-865-8 METHYL 2,3-O-ISOPROPYLIDENE-SS-D-RIBOFURANOSIDE 2,3-O-Isopropylidene-B-D-ribofuranoside 1-O-Methyl-2-O,3-O-isopropylidene-β-D-ribofuranose Methyl 2-O,3-O-(1-methylethylidene)-β-D-ribofuranoside Methyl 2-O,3-O-isopropylidene-β-D-ribofuranoside NSC 85191 Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside min. 98% (6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-methanol b-D-Ribofuranoside, methyl 2,3-O-(1-methylethylidene)- Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside USP/EP/BP (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-te TIANFU-CHEM Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside {6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl}methanol Methyl 2,3-O-(1-methylethylidene)-β-D-ribofuranoside 1-OMe-2,3-Isopropuidene-beta-D-ribofuranoside Capecitabine Impurity 32 β-D-Ribofuranoside, methyl 2,3-O-(1-methylethylidene)- Capecitabine Impurity 55 2,3-O-isopropylidine-1-O-methylribofuranose Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside, CAS 4099-85-8 ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside 4099-85-8 Carbohydrates & Derivatives